Neuronal Networks are fundamental to brain function and memory in health, aging, and neurodegenerative disease. The goal of the DZNE-wide Neuronal Networks Program is to uncover how changes in network activity relate to disease and to translate these insights into meaningful readouts and new therapeutic opportunities. 

The DZNE Neuronal Networks Program brings together world-leading expertise for a joint study of neuronal networks across multiple scales, from cells and circuits to large-scale systems and human-derived network models. By combining strengths across ten DZNE sites, the Neuronal Networks Program creates a coordinated preclinical research effort focused on understanding network dysfunction in neurodegenerative diseases and evaluating strategies to restore function. 

Using advanced recording, live imaging, neurotechnologies and AI alongside human-relevant model systems and disease-focused research, the program connects mechanistic discoveries with human brain function and disease progression.  

The work in the Neuronal Networks Program is designed to reveal network-level principles and biomarkers that can guide future interventions, support therapeutic development, and promote healthy cognitive aging. 
 

Our Flagship Projects 

1. Brains-on-a-Chip (Hayder Amin, DZNE Dresden) 

2. Precision Neuromodulation (Jan Gründemann, DZNE Bonn)