Fink R., Imai S., Gockel N., Lauer G., Renken K., Wietek J., Lamothe-Molina PJ., Fuhrmann F., Mittag M., Ziebarth T., Canziani A., Kubitschke M., Kistmacher V., Kretschmer A., Sebastian E., Ottens J., Schmitz D., Terai T., Gründemann J., Hassan SI., Patriarchi T., Reiner A., Fuhrmann M., Campbell RE., Masseck OA. PinkyCaMP: an mScarlet-based calcium sensor with enhanced brightness, photostability and multiplexing capabilities. Nature Methods. 2026; 23(5):998-1010. doi: 10.1038/s41592-026-03065-2. 

Askin B., Kilic C,. Cordero Gómez C., Duong SL., Domingues-Baquero A., Goihl A., Nalbach K., Petushi J., Grundschöttel P., Wagner J, Thomas V., Lamberty J., Withers E., Huber H., Huebschmann S., Semenova E., Turko P., Newman AG., Diez L., Beyer M., De Domenico E., Körtvelyessy P., Reinhold D., Schneider A., Neher JJ., Ulas T., Lichtenthaler SF., Rost BR., Schmitz D., Prüss H., Wegmann S. IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity. Science Advances. 2026 May 15;12(20):eaec2042. doi: 10.1126/sciadv.aec2042. Epub 2026 May 13. 

Benoit C. M., Ganea D. A., Paricio-Montesinos R., Esser J., Thome C., Janssen J. M., Sattin A., Innocenti S. M., Krabbe S., Lüthi A., Fellin T., Engelhardt M., Gründemann J. Axon initial segment dynamics during associative fear learning. Nature Neuroscience. 2026; 29(3):535-542. doi:10.1038/s41593-025-02152-5.  

Planert H., Mittermaier F. X., Grosser S., Fidzinski P., Schneider U. C., Radbruch H., Onken J., Holtkamp M., Schmitz D., Alle H., Vida I., Geiger J. R. P., Peng Y. Electrophysiological classification of human layer 2-3 pyramidal neurons reveals subtype-specific synaptic interactions. Nature Neuroscience. 2026; 29(2):455-466. doi:10.1038/s41593-025-02134-7.  

De Coster W., Van den Broeck M., Baker M., Ghayal N. B., Wynants S., Batzler A., Pottier C., Alidadiani S., Küçükali F., Jenkins G. D., Policarpo R., van Blitterswijk M., DeJesus-Hernandez M., Soto-Beasley A. I., Faura J., Coopman E., Hutten S., Mol M. O., Wallon D., Sieben A., Finger E. C., Murray M. E., Forrest S. L., Tartaglia M. C., Troakes C., van Rooij J. G. J., Nguyen A. T., Reichard R. R., Woodman N. L., Nana A. L., Weintraub S., Gefen T., De Vil B., Bodi I., Lopez O. L., Boluda S., Belliard S., Lebert F., Marguet F., Mao Q., Mesulam M. M., Boxer A. L., Vandenbulcke M., Suh E., Schaeverbeke J., Lambert J.-C., Scholz S. W., Dalgard C. L., Traynor B. J., Gibbs R. J., Schellenberg G. D., Dormann D., Joris G., De Pooter T., De Rijk P., D’Hert S., Van Dongen J., van der Zee J., Strazisar M., Gearing M., Kukar T., Flanagan M., Engelborghs S., Ghetti B., Newell K. L., King A., Roeber S., Rosen H. J., Spina S., Cras P., Ertekin-Taner N., Wszolek Z. K., Uitti R. J., Cheshire W. P., Singer W., Herms J., Josephs K. A., Whitwell J. L., Petersen R. C., Pasquier F., Nicolas G., Castellani R., Glass J., Miller B. L., Kovacs G. G., Rissman R. A., Hiniker A., Deramecourt V., Ang L.-C., Lee-Way J., Van Deerlin V. M., Dugger B. N., Thal D. R., Grinberg L. T., Cruchaga C., Arzberger T., Munoz D. G., Keith J., Zinman L., Rogaeva E., Lee E. B., Haggarty S. J., Ansorge O., Husain M., Halliday G. M., Al-Sarraj S., Ross O. A., Sleegers K., Vandenberghe R., Boeve B. F., Graff-Radford N. R., Kofler J., White III C. L., Lashley T., Neumann M., Biernacka J. M., Seeley W. W., Seelaar H., van Swieten J. C., Rohrer J. D., Dickson D. W., Mackenzie I. R. A., Rademakers R. A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions. Nature Genetics. 2026. doi:10.1038/s41588-026-02537-7.  

Zu J., Li C., Cui M., Liu X., Pan Z., Li X., Zhang F., Gentz J., Mitteregger-Kretzschmar G., Herms J., Shi Y. Pioglitazone attenuates complement-mediated microglial synaptic engulfment in an Alzheimer's disease model. Brain. 2026;149(2):668-679. doi:10.1093/brain/awaf462. 

Haetzel L. M., Gründemann J. Inhibitory inputs from thalamus promote resilient spiking in tail of striatum. iScience. 2025; 28(11):113880. doi:10.1016/j.isci.2025.113880.  

Favila N., Marsico J. C., Pacheco C. M., Kenet S., Escribano B., Bitterman Y., Gründemann J., Lüthi A., Krabbe S. Heterogeneous plasticity of amygdala interneurons in associative learning and extinction. Nature Communications. 2025;16(1):9926. doi:10.1038/s41467-025-66122-y.  

Fuhrmann F., Nebeling F. C., Musacchio F., Mittag M., Poll S., Müller M., Giovannetti E. A., Maibach M., Schaffran B., Burnside E., Chan C. W., Lagurin A. S., Reichenbach N., Kaushalya S. K., Fried H., Linden S., Petzold G. C., Tavosanis G., Bradke F., Fuhrmann M. Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution. Communications Biology. 2025;8(1):795. doi:10.1038/s42003-025-08079-8.  

Thome C., Janssen J. M., Karabulut S., Acuna C., D'Este E., Soyka S. J., Baum K., Bock M., Lehmann N., Roos J., Stevens N. A., Hasegawa M., Ganea D. A., Benoit C. M., Gründemann J., Min L. Y., Bird K. M., Schultz C., Bennett V., Jenkins P., Engelhardt M. Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice. eLife. 2025; 12:RP87078. doi:10.7554/eLife.87078.  

Griffin J. M., Bockemühl T., Randel B., Gröschl S., Papaioannou P., Büschges A., Bradke F. Targeted environmental enrichment is more effective than bipedal treadmill training after thoracic spinal cord injury. Brain Communications. 2025; 7(5):fcaf385. doi:10.1093/braincomms/fcaf385.  

Gavoci A., Zhiti A., Rusková M., Magiera M. M., Wang M., Ziegler K. A., Hausrat T. J., Ugwuja A. I., Chakraborty S., Engelhardt S., Kneussel M., Balastik M., Janke C., Misgeld T., Brill M. S. Polyglutamylation of microtubules drives neuronal remodeling. Nature Communications. 2025; 16(1):5384. doi:10.1038/s41467-025-60855-6. 

Meyer C., Niedermeier T., Feyen P. L. C., Strübing F. L., Rauchmann B. S., Karali K., Gentz J., Tillmann Y., Landgraf N. F., Rumpf S.-L., Ochs K., Wind-Mark K., Biechele G., Wagner J., Guersel S., Kurz C., Schweiger M., Prtvar D., Shi Y., Banati R. B., Liu G.-J., Middleton R. J., Mitteregger-Kretzschmar G., Perneczky R., Koeglsperger T., Neher J. J., Tahirovic S., Brendel M., Herms J., Paeger L. Early Locus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer's disease. Nature Communications. 2025; 16(1):7338. doi:10.1038/s41467-025-62500-8.  

Neubauer A., Weissenbrunner D., Pekrun S., Roeber S., Ruf V., Feyen P, Strübing FL, Herms J. Alpha-synuclein deposition patterns in Alzheimer's disease: association with cortical amyloid beta and variable tau load. Acta Neuropathologica. 2025. doi:10.1007/s00401-025-02952-w. 

Hasegawa M., Huang Z., Paricio-Montesinos R., Gründemann J. Network state changes in sensory thalamus represent learned outcomes. Nature Communications. 2024;15(1):7830. doi:10.1038/s41467-024-51868-8.  

Kagermeier T., Hauser S., Sarieva K., Laugwitz L., Groeschel S., Janzarik W. G., Yentür Z., Becker K., Schöls L., Kragelöh-Mann I., Mayer S. Human organoid model of pontocerebellar hypoplasia 2a recapitulates brain region-specific size differences. Disease Models & Mechanisms. 2024; 17(7):dmm050740. doi:10.1242/dmm.050740.  

Ku S.-P., Atucha E., Alavi N., Mulla-Osman H., Kayumova R., Yoshida M., Csicsvari J., Sauvage M. M. Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance. Cell Reports. 2024; 43(6):114276. doi:10.1016/j.celrep.2024.114276.  

Wietek J., Nozownik A., Pulin M., Saraf-Sinik I., Matosevich N., Gowrishankar R., Gat A., Malan D., Brown B., Dine J., Imambocus B., Levy R., Sauter K., Litvin A., Regev N., Subramaniam S., Abrera K., Summarli D., Goren E., Mizrachi G., Bitton E., Benjamin A., Copits B., Sasse P., Rost B., Schmitz D., Bruchas M., Soba P., Oren-Suissa M., Nir Y., Wiegert J., Yizhar O. A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits. Nature Methods. 2024; 21(7):1275-1287. doi:10.1038/s41592-024-02285-8.  

Chelini G., Mirzapourdelavar H., Durning P., Baidoe-Ansah D., Sethi M. K., O’Donovan S. M., Klengel T., Balasco L., Berciu C., Boyer-Boiteau A., McCullumsmith R., Ressler K. J., Zaia J., Bozzi Y., Dityatev A., Berretta S. Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice. Cell Reports. 2024; 43(5):114112. doi:10.1016/j.celrep.2024.114112.  

Peng Y., Bjelde A., Aceituno P. V., Mittermaier F. X., Planert H., Grosser S., Onken J., Faust K., Kalbhenn T., Simon M., Radbruch H., Fidzinski P., Schmitz D., Alle H., Holtkamp M., Vida I., Grewe B. F., Geiger J. R. P. Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit. Science. 2024;384(6693):338-343. doi:10.1126/science.adg8828.  

Korneck M., Leonhardt A., Schöls L., Hauser S. Generation of homozygous and heterozygous REEP1 knockout induced pluripotent stem cell lines by CRISPR/Cas9 gene editing. Stem Cell Research. 2024;77:103378. doi:10.1016/j.scr.2024.103378.  

Sammons R. P., Vezir M., Moreno-Velasquez L., Cano G., Orlando M., Sievers M., Grasso E., Metodieva V. D., Kempter R., Schmidt H., Schmitz D. Structure and function of the hippocampal CA3 module. Proceedings of the National Academy of Sciences USA. 2024; 121(6):e2312281120. doi:10.1073/pnas.2312281120. 

Blaess S., Krabbe S. Cell type specificity for circuit output in the midbrain dopaminergic system. Current Opinion in Neurobiology. 2023; 83:102811. doi:10.1016/j.conb.2023.102811.  

Tzilivaki A., Tukker J. J., Maier N., Poirazi P., Sammons R. P., Schmitz D. Hippocampal GABAergic interneurons and memory. Neuron. 2023;111(20):3154-3175. doi:10.1016/j.neuron.2023.06.016.  

Ying J., Reboreda A., Yoshida M., Brandon M. P. Grid cell disruption in a mouse model of early Alzheimer's disease reflects reduced integration of self-motion cues. Current Biology. 2023; 33(12):2425-2437.e5. doi:10.1016/j.cub.2023.04.065.  

Ramsaran A. I., Wang Y., Golbabaei A., Aleshin S., de Snoo M. L., Yeung B.-R. A., Rashid A. J., Awasthi A., Lau J., Tran L. M., Ko S. Y., Abegg A., Duan L. C., McKenzie C., Gallucci J., Ahmed M., Kaushik R., Dityatev A., Josselyn S. A., Frankland P. W. A shift in the mechanisms controlling hippocampal engram formation during brain maturation. Science. 2023; 380(6644):543-551. doi:10.1126/science.ade6530.  

Saber Marouf B., Reboreda A., Theissen F., Kaushik R., Sauvage M., Dityatev A., Yoshida M. TRPC4 channel knockdown in the hippocampal CA1 region impairs modulation of beta oscillations in novel context. Biology. 2023; 12(4):629. doi:10.3390/biology12040629.  

Cangalaya C., Wegmann S., Sun W., Diez L., Gottfried A., Richter K., Stoyanov S., Pakan J., Fischer K.-D., Dityatev A. Real-time mechanisms of exacerbated synaptic remodeling by microglia in acute models of systemic inflammation and tauopathy. Brain, Behavior, and Immunity. 2023; 110:245-259. doi:10.1016/j.bbi.2023.02.023.  

Wang Y., Krabbe S., Eddison M., Henry F. E., Fleishman G., Lemire A. L., Wang L., Korff W., Tillberg P. W., Lüthi A., Sternson S. Multimodal mapping of cell types and projections in the central nucleus of the amygdala. eLife. 2023; 12:e84262. doi:10.7554/eLife.84262.  

Ziegler K. A., Ahles A., Dueck A., Esfandyari D., Pichler P., Weber K., Kotschi S., Bartelt A., Sinicina I., Graw M., Leonhardt H., Weckbach L. T., Massberg S., Schifferer M., Simons M., Hoeher L., Luo J., Ertürk A., Schiattarella G. G., Sassi Y., Misgeld T., Engelhardt S. Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease. Science. 2023;381(6655):285-290. doi:10.1126/science.abn6366. 

Shi Y., Cui M., Ochs K., Brendel M., Strübing F., Briel N., Eckenweber F., Zou C., Banati R. B., Liu G.-J., Middleton R. J., Rupprecht R., Rudolph U., Zeilhofer H. U., Rammes G., Herms J., Dorostkar M. M. Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO). Nature Neuroscience. 2022; 25(3):317-329. doi:10.1038/s41593-022-01013-9.  

Schelski M., Bradke F. Microtubule retrograde flow retains neuronal polarization in a fluctuating state. Science Advances. 2022; 8(44):eabo2336. doi:10.1126/sciadv.abo2336. 

Helm J., Schöls L., Hauser S. Towards Personalized Allele-Specific Antisense Oligonucleotide Therapies for Toxic Gain-of-Function Neurodegenerative Diseases. Pharmaceutics. 2022; 14(8):1708. doi:10.3390/pharmaceutics14081708.  

Merseburg A., Kasemir J., Buss E. W., Leroy F., Bock T., Porro A., Barnett A., Tröder S. E., Engeland B., Stockebrand M., Moroni A., Siegelbaum S., Isbrandt D., Santoro B. Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy. eLife. 2022; 11:e70826. doi:10.7554/eLife.70826.  

d'Aquin S., Szonyi A., Mahn M., Krabbe S., Gründemann J., Lüthi A. Compartmentalized dendritic plasticity during associative learning. Science. 2022; 376(6590):eabf7052. doi:10.1126/science.abf7052.  

Hilton B. J., Husch A., Schaffran B., Lin T.-C., Burnside E. R., Dupraz S., Schelski M., Kim J., Müller J. A., Schoch S., Imig C., Brose N., Bradke F. An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury. Neuron. 2022; 110(1):51-69.e7. doi:10.1016/j.neuron.2021.10.007.  

Helm J., Weber C., Schöls L., Hauser S. Allele-specific targeting of mutant ataxin-3 by antisense oligonucleotides in SCA3-iPSC-derived neurons. Molecular Therapy Nucleic Acids. 2022; 27:99-108. doi:10.1016/j.omtn.2021.11.015. 

Sun W., Choi I., Stoyanov S., Senkov O., Ponimaskin E., Winter Y., Pakan J., Dityatev A. Context value updating and multidimensional neuronal encoding in the retrosplenial cortex. Nature Communications. 2021;12(1):6045. doi:10.1038/s41467-021-26301-z.  

Stern S., Hilton B. J., Burnside E. R., Dupraz S., Handley E. E., Gonyer J. M., Brakebusch C., Bradke F. RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury. Neuron. 2021;109(21):3436-3455.e9. doi:10.1016/j.neuron.2021.08.014.  

Hampel P., Römermann K., MacAulay N., Löscher W. A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior. Proceedings of the National Academy of Sciences USA. 2021; 118:e2014784118. doi:10.1073/pnas.2014784118.  

Ulbrich P., Jandke S., Patejdl R., Horn A. K. E., Dityatev A. Hippocampal hyperactivity in a rat model of Alzheimer's disease. Journal of Neurochemistry. 2021; 157(6):2128-2144. doi:10.1111/jnc.15323.  

Sare R. M., Harkless L., Levine M., Torossian A., Shekhtmeyster P., Blair L. J., Lo D. C., Thor A., Grinberg L. T., Seeley W. W., Farrell K., Kril J. J., Forrest S. L., Lemos R., Foti S., Santana-Codina N., Crary J. F., Cairns N. J., Duyckaerts C., Teich A. F., Wisch J., Vonsattel J., Montalto M., Haroutunian V., McKee A. C., Gomez-Isla T., Spina S., Schuck T., Piguet O., Halliday G. M., Pavlovic D., Mucke L., Kayed R., Foroud T. M., Frosch M. P., Xia C.-F., Ferrer I., Waters E. J., Ayer R., Maziuk B., Dage J., Grace I., Goate A., Lashley T., Dickson D. W., Hyman B. T., Irwin D. J., Schöll M. Niwaki Instead of Random Forests: targeted serial sectioning scanning electron microscopy with reimaging capabilities for exploring central nervous system cell biology and pathology. Frontiers in Neuroanatomy. 2021; 15:732506. doi:10.3389/fnana.2021.732506.  

Jafari M., Schumacher A.M., Snaidero N., Ullrich Gavilanes E.M., Neziraj T., Kocsis-Jutka V., Engels D., Jürgens T., Wagner I., Weidinger J.D.F., Schmidt S.S., Beltrán E., Hagan N., Woodworth L., Ofengeim D., Gans J., Wolf F., Kreutzfeldt M., Portugues R., Merkler D., Misgeld T., Kerschensteiner M. Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation. Nature Neuroscience. 2021;24(3):355-367. doi:10.1038/s41593-020-00780-7. 

Takeuchi Y., Shimada T., Otsuka S., Stoyanov S. B., Watanabe M., Takeuchi K., Dityatev A., Aricescu A. R., Yuzaki M. A synthetic synaptic organizer protein restores glutamatergic neuronal circuits. Science. 2020; 369(6507):eabb4853. doi:10.1126/science.abb4853.  

Meier K., Merseburg A., Isbrandt D., Marguet S. L., Morellini F. Dentate gyrus sharp waves, a local field potential correlate of learning in the dentate gyrus of mice. Journal of Neuroscience. 2020; 40(37):7105-7118. doi:10.1523/JNEUROSCI.2275-19.2020.  

Poll S., Mittag M., Musacchio F., Justus L. C., Giovannetti E. A., Steffen J., Wagner J., Zohren L., Schoch S., Schmidt B., Jackson W. S., Ehninger D., Fuhrmann M. Memory trace interference impairs recall in a mouse model of Alzheimer's disease. Nature Neuroscience. 2020; 23(8):952-958. doi:10.1038/s41593-020-0652-4.  

Falck J., Bruns C., Hoffmann S. S., Straub I., Plautz E. J., Orlando M., Munawar H., Rivalan M., Winter Y., Izsvák Z., Schmitz D., Hamra F. K., Hallermann S., Garner C. C., Ackermann F. Loss of Piccolo Function in Rats Induces Cerebellar Network Dysfunction and Pontocerebellar Hypoplasia Type 3-like Phenotypes. Journal of Neuroscience. 2020; 40(14):2943-2959. doi:10.1523/JNEUROSCI.2316-19.2020.  

Snaidero N., Schifferer M., Mezydlo A., Zalc B., Kerschensteiner M., Misgeld T. Myelin replacement triggered by single-cell demyelination in mouse cortex. Nature Communications. 2020; 11(1):4901. doi:10.1038/s41467-020-18632-0. 

Comprehensive investigation of AAV tropism across human iPSC-derived neuronal subtypes 
Publication date: 30 March 2026 https://doi.org/10.64898/2026.03.24.713895  

Intrinsic Cellular Persistent Firing Sustains Hippocampal Spatial Representations during Working Memory 
Publication date: 26 February 2026 https://doi.org/10.1101/2025.06.27.661493 

Local demyelination rekindles oligodendrocyte precursor dynamics and remyelination in old age 
Publication date: 16 February 2026 https://doi.org/10.64898/2026.02.15.705983 

Distinct TAF15 amyloid filament folds define multiple subtypes of FTLD-TAF15 
Publication date: 12 January 2026 https://doi.org/10.64898/2026.01.12.698957 

Intrinsic persistent firing in CA1 encodes elapsed time across behaviorally relevant scales 
Publication date: 13 December 2025 https://doi.org/10.64898/2025.12.10.693586 

Neuron subtypes have distinct mitochondrial transport in axons and vulnerability to tau in vivo 
Publication date: 15 October 2025 https://doi.org/10.21203/rs.3.rs-7628051/v1 

Piccolo Regulates Secretion of the Extracellular Matrix Components Brevican and Tenascin R from Astrocytes to Drive Synapse Formation: Implications for Pontocerebellar Hypoplasia Type 3 (PCH3) 
Publication date: 3 July 2025 https://doi.org/10.1101/2025.07.03.662734 

Early postnatal CA3 hyperexcitability drives hippocampal development and epileptogenesis in SCN2A developmental and epileptic encephalopathy 
Publication date: 29 June 2025 https://doi.org/10.1101/2025.06.29.661458 

PinkyCaMP a mScarlet-based calcium sensor with exceptional brightness, photostability, and multiplexing capabilities 
Publication date: 17 December 2024 https://doi.org/10.1101/2024.12.16.628673 

Dynamics of microglia-glioblastoma crosstalk at the far infiltration zone 
Publication date: 25 September 2024 https://doi.org/10.1101/2024.09.23.614016 

Inhibitory inputs from thalamus promote resilient spiking in tail of striatum 
https://doi.org/10.5281/zenodo.17250420 

Data for: Network state changes in sensory thalamus represent learned outcomes 
https://doi.org/10.12751/g-node.7xxnmw  

EASI-FISH reveals spatial and axonal projection patterns of molecularly defined cell types in the central amygdala (CEA) 
https://doi.org/10.25378/janelia.21171373  

Data: Heterogeneous plasticity of amygdala interneurons in associative learning and extinction 
https://doi.org/10.5281/zenodo.17390680