Plattforms & Technology
The Neuronal Networks Program is powered by advanced tools for dense neuronal activity recordings and imaging, spanning hIPSC-derived networks in a dish to preclinical animal models.
Platforms
- MEA platform (Dresden)
- Light Microscopy Facility (Bonn)
- Animal Research Facility (Bonn)
- High Performance Compute Cluster (Bonn)
- AAVs as tools for circuit repair (Magdeburg)
- Neuropixels Platform (Cologne/Bonn)
- Viral Core Facilities (Berlin, Munich; AAV, Lenti)
- SyNergy Nanoscale and Microscale Hubs (Munich)
- iPSC Screening Platform (Tübingen)
- AMBIO Imaging Facility (Berlin)
Techniques
- Multi-electrode arrays and microfluidics
- Benchtop two-photon and three-photon in vivo microscopy (incl. VR and mobile homecage)
- In vivo two-photon STED Imaging
- In vivo functional imaging (fMRI)
- Freely moving miniaturized microscopy (1 photon, 2 photon)
- All-optical microscopy techniques
- Dense in vivo electrophysiology (Neuronexus, Neuropixels)
- Multi-site fiber photometry for neuronal activity and neuromodulator release
- Fully customizable setups for multimodal recordings of neuronal data and freely moving behavior with reliable instrument synchonization
- Deep behavioral phenotyping platforms (incl. motor control)
- Multimodal AI for joint neuronal network and behavior analysis
- Slice electrophysiology and Patch-Seq
- Optogenetics / Chemogenetics
- Spatial transcriptomics
- Preclinical disease models
- Neuronal cultures incl. IPSC-derived human neurons and organoids
- Chronic video-ECoG telemetry (1 or 2 channel)
- Volume electron microscopy