Translationale Neurodegeneration
Prof. Dr. Günter Höglinger
Leiter der Klinischen Forschung
am Standort München,
Gruppenleiter
Feodor-Lynen-Str. 17
81377 München

guenter.hoeglinger@dzne.de
 +49 89 4400-46464

Publikationen

Die vollständige Publikationsliste findet man hier.

Axel Weber, Sigrid C. Schwarz, Jörg Tost, Dietrich Trümbach, Pia Winter, Florence Busato, Pawel Tacik, Anita C. Windhorst, Maud Fagny, Thomas Arzberger, Catriona McLean, John C. van Swieten, Johannes Schwarz, Daniela Vogt Weisenhorn, Wolfgang Wurst, Till Adhikary, Dennis W. Dickson, Günter U. Höglinger, Ulrich Müller. Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1. Nature Communications. 2018 Nov 30; 9 doi: 10.1038/s41467-018-05325-y
Adam L Boxer, Jin-Tai Yu, Lawrence I Golbe, Irene Litvan, Anthony E Lang, Günter U Höglinger. Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches. The Lancet Neurology. 2017 Jun 30; 16:552-563. doi: 10.1016/S1474-4422(17)30157-6
Günter U. Höglinger, Gesine Respondek, Maria Stamelou, Carolin Kurz, Keith A. Josephs, Anthony E. Lang, Brit Mollenhauer, Ulrich Müller, Christer Nilsson, Jennifer L. Whitwell, Thomas Arzberger, Elisabet Englund, Ellen Gelpi, Armin Giese, David J. Irwin, Wassilios G. Meissner, Alexander Pantelyat, Alex Rajput, John C. van Swieten, Claire Troakes, Angelo Antonini, Kailash P. Bhatia, Yvette Bordelon, Yaroslau Compta, Jean-Christophe Corvol, Carlo Colosimo, Dennis W. Dickson, Richard Dodel, Leslie Ferguson, Murray Grossman, Jan Kassubek, Florian Krismer, Johannes Levin, Stefan Lorenzl, Huw R. Morris, Peter Nestor, Wolfgang H. Oertel, Werner Poewe, Gil Rabinovici, James B. Rowe, Gerard D. Schellenberg, Klaus Seppi, Thilo van Eimeren, Gregor K. Wenning, Adam L. Boxer, Lawrence I. Golbe, Irene Litvan, Adam L. Boxer, Alex Rajput, Alexander Pantelyat, Angelo Antonini, Anthony E. Lang, Armin Giese, Brit Mollenhauer, Carlo Colosimo, Caroline Kurz, Christer Nilsson, Claire Troakes, David J. Irwin, Dennis W. Dickson, Ellen Gelpi, Florian Krismer, Gerard D. Schellenberg, Gesine Respondek, Gil Rabinovici, Gregor K. Wenning, Günter U. Höglinger, Huw R. Morris, Irene Litvan, James B. Rowe, Jan Kassubek, Jean-Christophe Corvol, Jennifer L. Whitwell, Johannes Levin, John van Swieten, Kailash P. Bhatia, Keith A. Josephs, Klaus Seppi, Lawrence I. Golbe, Maria Stamelou, Murray Grossman, Peter Nestor, Richard Dodel, Stefan Lorenzl, Thilo van Eimeren, Thomas Arzberger, Ulrich Müller, Wassilios G. Meissner, Werner Poewe, Wolfgang H. Oertel, Yaroslau Compta, Yvette Bordelon. Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria. Movement Disorders. 2017 May 31; 32:853-864. doi: 10.1002/mds.26987
Matthias Höllerhage, Claudia Moebius, Johannes Melms, Wei-Hua Chiu, Joachim N. Goebel, Tasnim Chakroun, Thomas Koeglsperger, Wolfgang H. Oertel, Thomas W. Rösler, Marc Bickle, Günter U. Höglinger. Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells. Scientific Reports. 2017 Nov 30; 7 doi: 10.1038/s41598-017-11664-5
Julius Bruch, Hong Xu, Thomas W Rösler, Anderson De Andrade, Peer-Hendrik Kuhn, Stefan F Lichtenthaler, Thomas Arzberger, Konstanze F Winklhofer, Ulrich Müller, Günter U Höglinger. PERK activation mitigates tau pathology in vitro and in vivo. EMBO Molecular Medicine. 2017 Feb 28; 9:371-384. doi: 10.15252/emmm.201606664
Naomi Kouri, Owen A. Ross, Beth Dombroski, Curtis S. Younkin, Daniel J. Serie, Alexandra Soto-Ortolaza, Matthew Baker, Ni Cole A. Finch, Hyejin Yoon, Jungsu Kim, Shinsuke Fujioka, Catriona A. Mclean, Bernardino Ghetti, Salvatore Spina, Laura B. Cantwell, Martin R. Farlow, Jordan Grafman, Edward D. Huey, Mi Ryung Han, Sherry Beecher, Evan T. Geller, Hans A. Kretzschmar, Sigrun Roeber, Marla Gearing, Jorge L. Juncos, Jean Paul G. Vonsattel, Vivianna M. Van Deerlin, Murray Grossman, Howard I. Hurtig, Rachel G. Gross, Steven E. Arnold, John Q. Trojanowski, Virginia M. Lee, Gregor K. Wenning, Charles L. White, Günter U. Höglinger, Ulrich Müller, Bernie Devlin, Lawrence I. Golbe, Julia Crook, Joseph E. Parisi, Bradley F. Boeve, Keith A. Josephs, Zbigniew K. Wszolek, Ryan J. Uitti, Neill R. Graff-Radford, Irene Litvan, Steven G. Younkin, Li-San Wang, Nilüfer Ertekin-Taner, Rosa Rademakers, Hakon Hakonarsen, Gerard D. Schellenberg, Dennis W. Dickson. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nature Communications. 2015 Jun 15; 6 doi: 10.1038/ncomms8247
Günter U. Höglinger, Daniel Alvarez-Fischer, Oscar Arias-Carrión, Miriam Djufri, Andrea Windolph, Ursula Keber, Andreas Borta, Vincent Ries, Rainer K. W. Schwarting, Dieter Scheller, Wolfgang H. Oertel. A new dopaminergic nigro-olfactory projection. Acta Neuropathologica. 2015 Sep 20; 130:333-348. doi: 10.1007/s00401-015-1451-y
Günter U. Höglinger, Nadine M. Melhem, Dennis W. Dickson, Patrick M. A. Sleiman, Li-San Wang, Lambertus Klei, Rosa Rademakers, Rohan De Silva, Irene Litvan, David E. Riley, John C. Van Swieten, Peter Heutink, Zbigniew K. Wszolek, Ryan J. Uitti, Jana Vandrovcova, Howard I. Hurtig, Rachel G. Gross, Walter Maetzler, Stefano Goldwurm, Eduardo Tolosa, Barbara Borroni, Pau Pastor, Laura B. Cantwell, Mi Ryung Han, Allissa Dillman, Marcel P. Van Der Brug, J Raphael Gibbs, Mark R. Cookson, Dena G. Hernandez, Andrew B. Singleton, Matthew J. Farrer, Chang-En Yu, Lawrence I. Golbe, Tamas Revesz, John Hardy, Andrew J. Lees, Bernie Devlin, Hakon Hakonarson, Ulrich Müller, Gerard D. Schellenberg, Roger L. Albin, Elena Alonso, Angelo Antonini, Manuela Apfelbacher, Steven E. Arnold, Jesus Avila, Thomas G. Beach, Sherry Beecher, Daniela Berg, Thomas D. Bird, Nenad Bogdanovic, Agnita J. W. Boon, Yvette Bordelon, Alexis Brice, Herbert Budka, Margherita Canesi, Wang Zheng Chiu, Roberto Cilia, Carlo Colosimo, Peter P. De Deyn, Justo Garcãa De Yebenes, Laura Donker Kaat, Ranjan Duara, Alexandra Durr, Sebastiaan Engelborghs, Giovanni Fabbrini, Nicole A. Finch, Robyn Flook, Matthew P. Frosch, Carles Gaig, Douglas R. Galasko, Thomas Gasser, Marla Gearing, Evan T. Geller, Bernardino Ghetti, Neill R. Graff-Radford, Murray Grossman, Deborah A. Hall, Lili-Naz Hazrati, Matthias Höllerhage, Joseph Jankovic, Jorge L. Juncos, Anna Karydas, Hans A. Kretzschmar, Isabelle Leber, Virginia M. Lee, Andrew P. Lieberman, Kelly E. Lyons, Claudio Mariani, Eliezer Masliah, Luke A. Massey, Catriona A. McLean, Nicoletta Meucci, Bruce L. Miller, Brit Mollenhauer, Jens C. Möller, Huw R. Morris, Chris Morris, Sean S. O'Sullivan, Wolfgang H. Oertel, Donatella Ottaviani, Alessandro Padovani, Rajesh Pahwa, Gianni Pezzoli, Stuart Pickering-Brown, Werner Poewe, Alberto Rabano, Alex Rajput, Stephen G. Reich, Gesine Respondek, Sigrun Roeber, Jonathan D. Rohrer, Owen A. Ross, Martin N. Rossor, Giorgio Sacilotto, William W. Seeley, Klaus Seppi, Laura Silveira-Moriyama, Salvatore Spina, Karin Srulijes, Peter St. George-Hyslop, Maria Stamelou, David G. Standaert, Silvana Tesei, Wallace W. Tourtellotte, Claudia Trenkwalder, Claire Troakes, John Q. Trojanowski, Juan C. Troncoso, Vivianna M. Van Deerlin, Jean Paul G. Vonsattel, Gregor K. Wenning, Charles L. White, Pia Winter, Chris Zarow, Anna L. Zecchinelli. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nature Genetics. 2010 Dec 31; 43:699-705. doi: 10.1038/ng.859
Höglinger GU, Breunig JJ, Depboylu C, Rouaux C, Michel PP, Alvarez-Fischer D, Boutillier AL, DeGregori J, Oertel WH, Rakic P, Hirsch EC, Hunot S. The pRb/E2F cell-cycle pathway mediates cell death in Parkinson’s disease. Proc Natl Acad Sci USA. 2007 Jan 01; 104:3585–3590.
Höglinger GU, Rizk P, Muriel MP, Duyckaerts C., Oertel WH, Caille I, Hirsch EC. Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nature Neuroscience. 2014 Jan 01; 7:726-735.

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