Translational Neurodegeneration
Prof. Dr. Günter Höglinger
Group Leader
Technische Universität München,
Lehrstuhl für Translationale Neurodegeneration
Feodor-Lynen-Str. 17
81377 München

guenter.hoeglinger@dzne.de
 +49 89 4400-46464

Publications

The complete list of publications is found here.

Levin J, Maaß S, Schuberth M, Giese A, Oertel WH, Poewe W, Trenkwalder C, Wenning GK, Mansmann U, Südmeyer M, Eggert K, Mollenhauer B, Lipp A, Löhle M, Classen J, Münchau A, Kassubek J, Gandor F, Berg D, Egert-Schwender S, Eberhardt C, Paul F, Bötzel K, Ertl-Wagner B, Huppertz HJ, Ricard I, Höglinger GU. Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2019 Aug 01; 18:724-735. doi: 10.1016/S1474-4422(19)30141-3
Axel Weber, Sigrid C. Schwarz, Jörg Tost, Dietrich Trümbach, Pia Winter, Florence Busato, Pawel Tacik, Anita C. Windhorst, Maud Fagny, Thomas Arzberger, Catriona McLean, John C. van Swieten, Johannes Schwarz, Daniela Vogt Weisenhorn, Wolfgang Wurst, Till Adhikary, Dennis W. Dickson, Günter U. Höglinger, Ulrich Müller. Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1. Nature Communications. 2018 Nov 30; 9 doi: 10.1038/s41467-018-05325-y
Adam L Boxer, Jin-Tai Yu, Lawrence I Golbe, Irene Litvan, Anthony E Lang, Günter U Höglinger. Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches. The Lancet Neurology. 2017 Jun 30; 16:552-563. doi: 10.1016/S1474-4422(17)30157-6
Höglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Nilsson C, Whitwell JL, Arzberger T, Englund E, Gelpi E, Giese A, Irwin DJ, Meissner WG, Pantelyat A, et al. Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria. Movement Disorders. 2017 May 31; 32:853-864. doi: 10.1002/mds.26987
Matthias Höllerhage, Claudia Moebius, Johannes Melms, Wei-Hua Chiu, Joachim N. Goebel, Tasnim Chakroun, Thomas Koeglsperger, Wolfgang H. Oertel, Thomas W. Rösler, Marc Bickle, Günter U. Höglinger. Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells. Scientific Reports. 2017 Nov 30; 7 doi: 10.1038/s41598-017-11664-5
Julius Bruch, Hong Xu, Thomas W Rösler, Anderson De Andrade, Peer-Hendrik Kuhn, Stefan F Lichtenthaler, Thomas Arzberger, Konstanze F Winklhofer, Ulrich Müller, Günter U Höglinger. PERK activation mitigates tau pathology in vitro and in vivo. EMBO Molecular Medicine. 2017 Feb 28; 9:371-384. doi: 10.15252/emmm.201606664
Naomi Kouri, Owen A. Ross, Beth Dombroski, Curtis S. Younkin, Daniel J. Serie, Alexandra Soto-Ortolaza, Matthew Baker, Ni Cole A. Finch, Hyejin Yoon, Jungsu Kim, Shinsuke Fujioka, Catriona A. Mclean, Bernardino Ghetti, Salvatore Spina, Laura B. Cantwell, Martin R. Farlow, Jordan Grafman, Edward D. Huey, Mi Ryung Han, Sherry Beecher, Evan T. Geller, Hans A. Kretzschmar, Sigrun Roeber, Marla Gearing, Jorge L. Juncos, Jean Paul G. Vonsattel, Vivianna M. Van Deerlin, Murray Grossman, Howard I. Hurtig, Rachel G. Gross, Steven E. Arnold, John Q. Trojanowski, Virginia M. Lee, Gregor K. Wenning, Charles L. White, Günter U. Höglinger, Ulrich Müller, Bernie Devlin, Lawrence I. Golbe, Julia Crook, Joseph E. Parisi, Bradley F. Boeve, Keith A. Josephs, Zbigniew K. Wszolek, Ryan J. Uitti, Neill R. Graff-Radford, Irene Litvan, Steven G. Younkin, Li-San Wang, Nilüfer Ertekin-Taner, Rosa Rademakers, Hakon Hakonarsen, Gerard D. Schellenberg, Dennis W. Dickson. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nature Communications. 2015 Jun 15; 6 doi: 10.1038/ncomms8247
Günter U. Höglinger, Daniel Alvarez-Fischer, Oscar Arias-Carrión, Miriam Djufri, Andrea Windolph, Ursula Keber, Andreas Borta, Vincent Ries, Rainer K. W. Schwarting, Dieter Scheller, Wolfgang H. Oertel. A new dopaminergic nigro-olfactory projection. Acta Neuropathologica. 2015 Sep 20; 130:333-348. doi: 10.1007/s00401-015-1451-y
Höglinger GU, Melhem NM, Dickson DW, Sleiman P M.A, Wang L.S, Klei L, Rademakers R, De Silva R, Litvan I, Riley DE, Van Swieten JC, et al. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nature Genetics. 2010 Dec 31; 43:699-705. doi: 10.1038/ng.859
Höglinger GU, Breunig JJ, Depboylu C, Rouaux C, Michel PP, Alvarez-Fischer D, Boutillier AL, DeGregori J, Oertel WH, Rakic P, Hirsch EC, Hunot S. The pRb/E2F cell-cycle pathway mediates cell death in Parkinson’s disease. Proc Natl Acad Sci USA. 2007 Jan 01; 104:3585–3590.
Höglinger GU, Rizk P, Muriel MP, Duyckaerts C., Oertel WH, Caille I, Hirsch EC. Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nature Neuroscience. 2014 Jan 01; 7:726-735.

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