Clinical Research at the DZNE
DZNE's clinical research aims to develop new and effective therapies for neurodegenerative diseases. In order to achieve this, not only treatment studies are required. Rather, diagnostic procedures must also be improved so that diseases can be identified earlier and classified more accurately.
The Clinical Research of the DZNE is supported by the Clinical Network, made up of the DZNE locations Berlin, Bonn, Dresden, Göttingen, Magdeburg, Munich, Rostock/Greifswald und Tübingen and is coordinated from Bonn. The Clinical Network enables large studies to be conducted according to uniform standards.
First brain changes occur in neurodegenerative diseases more than ten years before the onset of disease symptoms. When the diagnosis is made, extensive irreversible brain damage already exists, so that many therapies are too late. Clinical research develops new biomarkers that enable earlier diagnosis and define subgroups of diseases through detailed investigations of risk individuals and patients. In the future, these markers will be used to test therapy approaches in the early stages of diseases and to apply therapies more individually.
Treatment studies are conducted by the DZNE as self-initiated studies and in cooperation with partners from the pharmaceutical industry. Special attention is paid to the rapid transfer of fundamental research results into clinical applications.
Information about the clinical research can also be downloaded here (in German only):
Flyer Klinische Forschung.
Clinical Research Platform - CRP
The multi-site studies of the DZNE are supported and coordinated by the
Clinical Research Platform ...
Databases of Clinical Research
Here you'll find the Databases of DZNE's Clinical Research.
Further information regarding the access requirements can be found here.
Support: In case of questions or issues, please contact the data management of the clinical research platform: data-management-kf@dzne.de.
Requirements: The request form for database access, the declaration of commitment and the regulations for use of Clinical Research databases, data and biomaterial samples of the DZNE can be downloaded here:
- Request for access to the databases of the clinical research (German only)
- Declaration of commitment by users of the clinical databases (German only)
- Regulations for use of Clinical Research databases, data and biomaterials of the DZNE
The request form can be sent either by mail or by e-mail or fax, the declaration of commitment by mail only to the rights management of the clinical research.
The mail adress is:
Deutsches Zentrum für Neurodegenerativer Erkrankungen e.V.
Klinische Forschungsplattform - Rechtemanagement
Venusberg-Campus 1, Gebäude 99
D-53127 Bonn
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Clinical Data Search Tool - CDST
The Clinical Data Search Tool - CDST offers the opportunity to retrieve information on available data/materials from clinical research studies.
The CDST provides purely qualitative information (no number of available datasets) such as
- Forms (= examinations such as tests, scales, imaging, biomaterial, etc.) and
- Parameters (= Variables/Items),
for which results are available in the clinical research databases for a particular study.
For each study
- individual forms completely (> Formular drucken) as well as
- parameters from several forms (> ausgewählte Items: … > Auswahl drucken)
can be saved as a PDF file and, if necessary, attached to the Request for Data and Biomaterial.
Please note that this does not replace the request, it can serve only as a supplement.
Request for Data and Biomaterial / Biobank Report
The data/biomaterial request form and the regulations for use of Clinical Research databases, data and biomaterial can be downloaded here:
- Data/Biomaterial Request Form
- Regulations for use of Clinical Research databases, data and biomaterials of the DZNE
Please, send the request form to klinische-studien@dzne.de.
Please also use the Clinical Data Search Tool - CDST to specify your request or to clarify in advance which parameters/biomaterial samples/MRT sequences/QA information/analysis results are available for the individual studies.
- Report of DZNE's Clinical Research Biobank (German only)
Important note: In case PDF-documents are not displayed properly using Firefox, e.g. without editable form fields, follow these instructions and choose "Use Adobe Reader": Disable built-in pdf viewer and use another viewer
Central Contact Management / Content Responsibility
Central Contact Management
The central contact management is the point of contact for study participants (probands).
zentrale-kontaktstelle-kf@dzne.de
Content responsibility
The Clinical Research Platform is responsible for the contents of DZNE's Clinical Research website.
Prof. Dr. Thomas Klockgether
Director of Clinical Research
Head of Clinical Research Bonn
ZKF Journal Club
Date/Time: | February 6, 2020, 03:00 p.m. |
Location: DZNE Bonn, Room A.1.107,
Venusberg-Campus 1 (Building 99), 53127 Bonn
Contact for email notifications:
marcel.daamen@dzne.de.
