The clinical research in Dresden focuses on the role of resilience mechanisms for the transition from healthy ageing to the onset of neurodegenerative diseases.
Important research areas:
- Mechanisms of healthy and pathological aging and its role in the transition from predecessor stages to the onset of neurodegenerative diseases (resilience mechanisms and how they can be influenced by lifestyle),
- age-related macular degeneration, the most important neurodegenerative disease of the eye,
- translation from the patient into laboratory work using stem cell models of neurodegenerative diseases.
- translation from laboratory work to patient through development and validation of neuroprotective strategies.
- translation of behavioural neurobiological investigations on cerebral plasticity.
- improvements in the care of Parkinson's patients through the application of digital technologies and intersectoral networking.
- influence of dementia risk factors on brain structure and function.
- cognitive performance changes in neuropsychiatric diseases.
- predictors of conversion to dementia in mild cognitive disorders.
- bidirectional relationship between sleep disorders and dementias.
- importance of sleep for cognitive processes in neurodegenerative diseases.
- establishment of progression markers for motoneuron diseases (amyotrophic lateral sclerosis and spinal muscular atrophy)
- role of mitochondrial fission and fusion processes in the pathogenesis of amyotrophic lateral sclerosis using patient-specific motoneuron cell cultures.
Clinical research at the DZNE site in Dresden utilizes a network of clinics and institutes at the University Hospital Carl Gustav Carus.
Head of Clinical Research Dresden
Clinical Research Groups / Principle Investigators
- Dr. Moritz Brandt
- Prof. Dr. Markus Donix
- Dr. Klaus Fabel
- Prof. Dr. Björn Falkenburger
- Dr. Rene Günther
- Prof. Dr. Mike O. Karl - Regeneration und Degeneration der Netzhaut
- Dr. Lisa Klingelhöfer
- Dr. Kai Löwenbrück
- Dr. Miranka Wirth