Ausgewählte Publikationen
The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130
Molecular neurodegeneration 18(1), 13 (2023) [10.1186/s13024-023-00596-6]
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Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activity.
EMBO molecular medicine 14(10), e16084 (2022) [10.15252/emmm.202216084]
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ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion.
EMBO reports 23(6), e54305 (2022) [10.15252/embr.202154305]
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The case for low-level BACE1 inhibition for the prevention of Alzheimer disease.
Nature reviews / Neurology 17(11), 703 - 714 (2021) [10.1038/s41582-021-00545-1]
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An optimized quantitative proteomics method establishes the cell type-resolved mouse brain secretome.
The EMBO journal 39(20), e105693 (2020) [10.15252/embj.2020105693]
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Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3
The EMBO journal 39(15), e103457 (2020) [10.15252/embj.2019103457]
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Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.
Nature reviews / Neuroscience 22(10), 1731-1742 (2019) [10.1038/s41593-019-0479-z]
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NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease.
EMBO molecular medicine 11(4), e9695 (2019) [10.15252/emmm.201809695]
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Pathology-linked protease caught in action.
Science / Science now 363(6428), 690-691 (2019) [10.1126/science.aaw5547]
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Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments.
The EMBO journal 37(15), e99456 (2018) [10.15252/embj.201899456]
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Non-cell-autonomous function of DR6 in Schwann cell proliferation.
The EMBO journal 37(7), e97390 (2018) [10.15252/embj.201797390]
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