Translationale Hirnforschung
Prof. Dr. Jochen Herms
Gruppenleiter
Die Gruppe "Translationale Hirnforschung" ist dem Lehrstuhl für Neuropathologie von Prof. Herms (LMU München) assoziiert.
Feodor-Lynen-Str. 17
81377 München

jochen.herms@dzne.de
 +49 89 4400-46427

Publikationen

Die vollständige Publikationsliste findet man hier.

Herms J, Dorostkar MM. Dendritic Spine Pathology in Neurodegenerative Diseases. Annu Rev Pathol. 2016 Jan 01; 11:221-50.
Chengyu Zou, Yuan Shi, Jasmin Ohli, Ulrich Schüller, Mario M. Dorostkar, Jochen Herms. Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer’s disease. Acta Neuropathologica. 2016 Jan 31; 131:235-246. doi: 10.1007/s00401-015-1527-8
Chengyu Zou, Sophie Crux, Stephane Marinesco, Elena Montagna, Carmelo Sgobio, Yuan Shi, Song Shi, Kaichuan Zhu, Mario M Dorostkar, Ulrike C Müller, Jochen Herms. Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis. EMBO Journal. 2016 Oct 16; 35:2213-2222. doi: 10.15252/embj.201694085
Michael Willem, Sabina Tahirovic, Marc Aurel Busche, Saak V. Ovsepian, Magda Chafai, Scherazad Kootar, Daniel Hornburg, Lewis D.B. Evans, Steven Moore, Anna Daria, Heike Hampel, Veronika Müller, Camilla Giudici, Brigitte Nuscher, Andrea Wenninger-Weinzierl, Elisabeth Kremmer, Michael T. Heneka, Dietmar R. Thal, Vilmantas Giedraitis, Lars Lannfelt, Ulrike Müller, Frederick J. Livesey, Felix Meissner, Jochen Herms, Arthur Konnerth, Hélène Marie, Christian Haass. σ-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature. 2015 Oct 14; 526:443-447. doi: 10.1038/nature14864
Chengyu Zou, Elena Montagna, Yuan Shi, Finn Peters, Lidia Blazquez-Llorca, Song Shi, Severin Filser, Mario M. Dorostkar, Jochen Herms. Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer’s disease. Acta Neuropathologica. 2015 Jun 25; 129:909-920. doi: 10.1007/s00401-015-1421-4
Filser S, Ovsepian SV,Masana M, Blazquez-Llorca L, Brandt Elvang A, Volbracht C, Müller MB, Jung CK, Herms J. Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions. Biol Psychiatry. 2015 Jan 01; 77:729-39.
Ochs, Dorostkar, Aramuni, Schön, Filser, Pöschl, Kremer, Van Leuven, Ovsepian, Herms. Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin. Molecular Psychiatry. 2015 Apr 01; 20:482-489. doi: 10.1038/mp.2014.55
Johanna Neuner, Saak V. Ovsepian, Mario Dorostkar, Severin Filser, Aayush Gupta, Stylianos Michalakis, Martin Biel, Jochen Herms. Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb. Nature Communications. 2014 May 27; 5 doi: 10.1038/ncomms4915
Tobias Bittner, Steffen Burgold, Mario M. Dorostkar, Martin Fuhrmann, Bettina M. Wegenast-Braun, Boris Schmidt, Hans Kretzschmar, Jochen Herms. Amyloid plaque formation precedes dendritic spine loss. Acta Neuropathologica. 2012 Nov 30; 124:797-807. doi: 10.1007/s00401-012-1047-8
Fuhrmann M, Bittner T, Jung CKE, Burgold S, Page RM, Mitteregger G, Haass C, LaFerla FM, Kretzschmar HA, Herms J. Microglia CX3CR1 knockout prevents neuron loss in an Alzheimer`s disease mouse model. Nature Neurosci. 2010 Jan 01; 13:411-413.

Info-Hotline

Donnerstags 13.30-16.30 Uhr

Für Patienten 0800-7799001

(kostenlos)

Für Ärzte 01803-779900

(9 Cent/Min. dt. Festnetz, mobil evtl. teurer)