Site Bonn

With some 600 employees, Bonn is the DZNE’s largest site as well as the seat of the Executive Board and the central administration. The location’s research covers a wide variety of topics and disciplines, ranging from studies in the laboratory to human clinical studies and population health studies.

In addition to researching the mechanisms of brain diseases, such as Alzheimer’s, Parkinson’s, and vascular dementia, the scientists in Bonn also dedicate their efforts to the molecular processes underlying spinal cord injuries. They also study aging processes at the microscopic level, the role of the immune system in brain diseases, and how neurons develop, connect, and contribute to memory function.

Through human clinical studies, experts at the DZNE in Bonn are also conducting research to improve the early detection of dementia and movement disorders and to develop new therapies and drugs. They are particularly interested in the detection of “biomarkers,” which are biological indicators (such as in the blood or cerebrospinal fluid) that can be used to detect a disease and assess how it will progress in the future. Many DZNE clinical studies are multi-site to include the largest number of participants possible. The coordination office for these nationwide activities is based in Bonn.

Through the “Rhineland Study,” the DZNE is investigating how health and the brain develop over the course of a lifetime and what impact factors such as lifestyle habits have on this. Up to 20,000 adults from Bonn and the surrounding area are being followed over a period of decades. Findings from the study are expected to contribute to personalized health care, improved early detection, and therapies for dementia and other age-related diseases.

Another research focus in Bonn is on “systems medicine," which combines methods from biology, medicine, data science, and biotechnology into a holistic approach to gain insight into the complex events of disease. State-of-the-art laboratory and data analysis methods are used, such as single-cell genomics and artificial intelligence.

Address

Board & Administration

Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE)
Venusberg-Campus 1/99
53127 Bonn

Research Groups

Population & Clinical Neuroepidemiology
Dr. Dr. Ahmad Aziz

Ageing and Neurodegeneration
Dr. Daniele Bano

Immunogenomics & Neurodegeneration
Priv.-Doz. Dr. Marc Beyer

Axon Growth and Regeneration
Prof. Dr. Frank Bradke

Population Health Sciences
Prof. Dr. Dr. Monique M. B. Breteler

Immunoregulation
Dr. Melania Capasso

Neurodegeneration and Neuroprotection in Parkinson's Disease
Prof. Donato Di Monte

Demographic Studies
Prof. Dr. Gabriele Doblhammer

Molecular and Cellular Cognition
Dr. Dan Ehninger

Neuroimmunology and Imaging
Dr. Martin Fuhrmann

Neural Circuit Computations
Prof. Dr. Jan Gründemann

Microglia and Neuroinflammation
Dr. Annett Halle

Pharmacoepidemiology
Priv.-Doz. Dr. Britta Hänisch

Experimental Neurophysiology
Prof. Dr. Dirk Isbrandt

Patient Studies
Prof. Dr. Thomas Klockgether

Functional Diversity of Neural Circuits
Dr. Sabine Krabbe

Statistics and Machine Learning
Dr. Sach Mukherjee

Synaptic Connectivity and Neurodegeneration
Prof. Dr. Dr. Pierluigi Nicotera

Vascular Neurology
 Prof. Dr. Gabor Petzold

Artificial Intelligence in Medical Imaging
Prof. Dr. Martin Reuter

Neonatal Neuroscience
Priv.-Doz. Dr. Hemmen Sabir

Nuclear Function in CNS pathophysiology
Prof. Dr. Paolo Salomoni

Translational Dementia Research
Prof. Dr. Anja Schneider

Clinical Single Cell Omics (CSCO) /Systems Medicine
Prof. Dr. Joachim L. Schultze

MR Physics
Prof. Dr. Tony Stöcker

Neuronal Circuits Dynamics
Prof. Dr. Gaia Tavosanis

Prion Cell Biology
Prof. Dr. Ina Vorberg

Cooperation Units

Prof. Dr. Henning Boecker
University Hospital Bonn
Leader Clinical Functional Neuroimaging

Prof. Dr. Michael Heneka
University Hospital Bonn
Director of the Department of Neurodegenerative Diseases and Gerontopsychiatry

Prof. Dr. Frank Jessen
University Hospital Cologne
Director Clinic of Psychiatry and Psychotherapy

Prof. Dr. Eicke Latz
University Hospital Bonn
Director of Institute of Innate Immunity

Prof. Dr. Michael Wagner
University Hospital Bonn
Leading Psychologist at Clinic for Psychatry and Psychotherapy

Prof. Dr. Ullrich Wüllner
University Hospital Bonn
Leader Genebank Parkinson´s disease (GEPARD)

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