Areas of investigation/research focus
The aim of our work is studying mechanisms of perinatal brain injury and establishing neuroprotective strategies. We use different methods as long-term neurofunctional outcome tests and cell-specific profiling.
The main focus is on:
- mechanisms of inflammation-sensitized experimental hypoxic-ischemic brain injury with and without hypothermia
- defining the role of microglia in our models of perinatal brain injury (hypoxia-ischemia, inflammation, prematurity)
- establishing early biomarkers of adverse outcome in our models
- establishing neuroprotective strategies
Key publications
Serdar M, Kempe K, Rizazad M, Herz J, Bendix I, Felderhoff-Müser U, Sabir H. Early Pro-inflammatory Microglia Activation After Inflammation-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal Rats. Front Cell Neurosci. 2019 May 24;
13:237.
doi: 10.3389/fncel.2019.00237
Falck M, Osredkar D, Wood TR, Maes E, Flatebø T, Sabir H, Thoresen M. Neonatal Systemic Inflammation Induces Inflammatory Reactions and Brain Apoptosis in a Pathogen-Specific Manner. Neonatology. 2018 Jan 01;
113:212-220.
doi: 10.1159/000481980
Sabir H, Osredkar D, Maes E, Wood T, Thoresen M. Xenon combined with therapeutic hypothermia is not neuroprotective after severe hypoxia-ischemia in neonatal rats. PLoS One. 2016 Jun 02;
11:e0156759.
doi: 10.1371/journal.pone.0156759
Osredkar D, Thoresen M, Maes E, Flatebø T, Elstad M, Sabir H. Hypothermia is not neuroprotective after infection-sensitized neonatal hypoxic-ischemic brain injury. Resuscitation. 2014 Apr 01;
85:567-72.
doi: 10.1016/j.resuscitation.2013.12.006
Sabir H, Scull-Brown E, Liu X, Thoresen M. Immediate hypothermia is not neuroprotective after severe hypoxia-ischemia and is deleterious when delayed by 12 hours in neonatal rats. Stroke. 2012 Dec 01;
43:3364-70.
doi: 10.1161/STROKEAHA.112.674481