Reliable integration of an ever-changing multitude of sensory inputs from the environment is the basis for learning and memory and shapes our behaviours. Our research aims to understand how sensory inputs are represented and computed to elucidate key principals of multisensory integration. To address this question, we combine state of the art circuit neuroscience tools like opto- and pharmacogenetics with single and two-photon imaging techniques to reveal computational frameworks of multisensory integration in deep brain areas and their effects on behaviour and learning in health and disease.