Molecular and Cellular Cognition
Priv.-Doz. Dr. Dan Ehninger
Group Leader
Sigmund-Freud-Str. 27
53127 Bonn

dan.ehninger@dzne.de
 +49 228 43302-530

Areas of investigation/research focus

Our group is interested in the pathogenesis of aging-associated and neuropsychiatric disorders and in the development of novel therapeutics for these diseases. Towards this end, we employ mouse models and multidisciplinary experimental approaches that combine pharmacology and genetics with physiological assessments, pathological analyses, genomics and epigenomics, biochemistry, as well as molecular and cell biology. The group is also interested in translating findings from preclinical models to human populations.

Specifically, we have a long-standing interest in mechanisms of neuropsychiatric disorders, which we explore in suitable mouse models (e.g., Ehninger et al., Nat Med 2008; Neuron 2008; Ehninger et al., Mol Psychiatry 2012; Zhou et al., Neuron 2013; Lee et al., Nat Neurosci 2014). Current work in our laboratory is also focused on clarifying the role of key lifespan-regulatory pathways in influencing aging and the pathogenesis of age-related disorders (e.g., Neff et al., J Clin Invest 2013; Xie et al., Nat Commun 2017, see also Bellantuono et al., Nature 2018). We are also interested in addressing if and how age-related, as well as environmentally induced epigenetic changes interact with health and disease outcomes, both in directly exposed individuals, as well as possibly inter- and/or transgenerationally (e.g., Ryan et al., Mol Psychiatry 2017; Henzel et al., Sci Rep 2017; Xie et al., PNAS 2018).

Key Publications

Kan Xie, Devon P. Ryan, Brandon L. Pearson, Kristin S. Henzel, Frauke Neff, Ramon O. Vidal, Magali Hennion, Isabelle Lehmann, Melvin Schleif, Susanne Schröder, Thure Adler, Birgit Rathkolb, Jan Rozman, Anna-Lena Schütz, Cornelia Prehn, Michel E. Mickael, Marco Weiergräber, Jerzy Adamski, Dirk H. Busch, Gerhard Ehninger, Anna Matynia, Walker S. Jackson, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Stefan Bonn, Martin Hrabě de Angelis, Dan Ehninger. Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice. Proc Natl Acad Sci USA. 2018 Feb 21; doi: 10.1073/pnas.1707337115
Kan Xie, Frauke Neff, Astrid Markert, Jan Rozman, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Robert Brommage, Lillian Garrett, Kristin S. Henzel, Sabine M. Hölter, Dirk Janik, Isabelle Lehmann, Kristin Moreth, Brandon L. Pearson, Ildiko Racz, Birgit Rathkolb, Devon P. Ryan, Susanne Schröder, Irina Treise, Raffi Bekeredjian, Dirk H. Busch, Jochen Graw, Gerhard Ehninger, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Michael Sandholzer, Carsten Schmidt-Weber, Marco Weiergräber, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě De Angelis, Dan Ehninger. Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice. Nat Commun. 2017 Nov 30; 8 doi: 10.1038/s41467-017-00178-3
Ryan, Henzel, Pearson, Siwek, Papazoglou, Guo, Paesler, Yu, Müller, Xie, Schröder, Becker, Garrett, Hölter, Neff, Rácz, Rathkolb, Rozman, Ehninger, Klingenspor, Klopstock, Wolf, Wurst, Zimmer, Fuchs, Gailus-Durner, Hrabě De Angelis, Sidiropoulou, Weiergräber, Zhou, Ehninger. A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice. Mol Psychiatry. 2018 Apr 30; 23:1345-1355. doi: 10.1038/mp.2017.53
Frauke Neff, Diana Flores-Dominguez, Devon P. Ryan, Marion Horsch, Susanne Schröder, Thure Adler, Luciana Caminha Afonso, Juan Antonio Aguilar-Pimentel, Lore Becker, Lillian Garrett, Wolfgang Hans, Moritz M. Hettich, Richard Holtmeier, Sabine M. Hölter, Kristin Moreth, Cornelia Prehn, Oliver Puk, Ildikó Rácz, Birgit Rathkolb, Jan Rozman, Beatrix Naton, Rainer Ordemann, Jerzy Adamski, Johannes Beckers, Raffi Bekeredjian, Dirk H. Busch, Gerhard Ehninger, Jochen Graw, Heinz Höfler, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Jörg Stypmann, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabe De Angelis, Dan Ehninger. Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest. 2013 Jul 31; 123:3272-3291. doi: 10.1172/JCI67674
Dan Ehninger, Sangyeul Han, Carrie Shilyansky, Yu Zhou, Weidong Li, David J. Kwiatkowski, Vijaya Ramesh, Alcino J. Silva. Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nat Med. 2008 Aug 01; 14:843-8. doi: 10.1038/nm1788

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