Axon Growth and Regeneration
Prof. Dr. Frank Bradke
Group Leader
Sigmund-Freud-Str. 27
53127 Bonn
 +49 228 43302-688 Sekretariat

Areas of investigation/research focus

Research in the Bradke lab focuses on how nerve cells grow during development and how these processes can be reactivated to induce nerve regeneration in the injured spinal cord.

This laboratory has a special interest in the skeleton of the cell, called the cytoskeleton.

Bradke and his coworkers showed that manipulation of the cytoskeleton with low doses of anticancer drugs leads to regrowth of nerves and reduction of scarring.

His lab also developed a novel imaging technique that enables visualization of nerves at microscopic resolution within whole tissue.

Key Publications

Tedeschi A, Dupraz S, Laskowski CJ, Xue J, Ulas T, Beyer M, Schultze JL, Bradke F. The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS. Neuron. 2016 Oct 19; 92:419-434. doi: 10.1016/j.neuron.2016.09.026
Ruschel J, Hellal F, Flynn KC, Dupraz S, Elliott DA, Tedeschi A, Bates M, Sliwinski C, Brook G, Dobrindt K, Peitz M, Brüstle O, Norenberg MD, Blesch A, Weidner N, Bunge MB, Bixby JL, Bradke F. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. Science. 2015 Apr 07; 348:347-52. doi: 10.1126/science.aaa2958
Flynn KC, Hellal F, Neukirchen D, Jacob S, Tahirovic S, Dupraz S, Stern S, Garvalov BK, Gurniak C, Shaw AE, Meyn L, Wedlich-Söldner R, Bamburg JR, Small JV, Witke W, Bradke F. ADF/cofilin-mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain. Neuron. 2012 Dec 20; 76:1091-107. doi: 10.1016/j.neuron.2012.09.038
Ertürk A, Mauch CP, Hellal F, Förstner F, Keck T, Becker K, Jährling N, Steffens H, Richter M, Hübener M, Kramer E, Kirchhoff F, Dodt HU, Bradke F. 3D imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury. Nature Medicine. 2011 Jan 01; 18:166-171.
Hellal F, Hurtado A, Ruschel J, Flynn KC, Laskowski CJ, Umlauf M, Kapitein LC, Strikis D, Lemmon V, Bixby J, Hoogenraad CC, Bradke F. Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury. Science. 2011 Feb 18; 331:928-31. doi: 10.1126/science.1201148


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