Frank Bradke
Axon Growth and Regeneration
Prof. Dr. Frank Bradke
Group Leader
Venusberg-Campus 1/99
53127  Bonn
 +49 228 43302-688

Areas of investigation/research focus

Research in the Bradke lab focuses on how nerve cells grow during development and how these processes can be reactivated to induce nerve regeneration in the injured spinal cord.

This laboratory has a special interest in the skeleton of the cell, called the cytoskeleton.

Bradke and his coworkers showed that manipulation of the cytoskeleton with low doses of anticancer drugs leads to regrowth of nerves and reduction of scarring.

His lab also developed a novel imaging technique that enables visualization of nerves at microscopic resolution within whole tissue.

Key Publications

Santos TE, Schaffran B, Broguière N, Meyn L, Zenobi-Wong M, Bradke F. Axon Growth of CNS Neurons in Three Dimensions Is Amoeboid and Independent of Adhesions. Cell Rep. 2020 Jul 21; 32:107907. doi: 10.1016/j.celrep.2020.107907
Dupraz S, Hilton BJ, Husch A, Santos TE, Coles CH, Stern S, Brakebusch C, Bradke F. RhoA Controls Axon Extension Independent of Specification in the Developing Brain. Curr Biol. 2019 Oct 23; doi: 10.1016/j.cub.2019.09.040
Tedeschi A, Dupraz S, Curcio M, Laskowski CJ, Schaffran B, Flynn KC, Santos TE, Stern S, Hilton BJ, Larson MJE, Gurniak CB, Witke W, Bradke F. ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS. Neuron. 2019 Jul 30; doi: 10.1016/j.neuron.2019.07.007
Hilton BJ, Blanquie O, Tedeschi A, Bradke F. High-resolution 3D imaging and analysis of axon regeneration in unsectioned spinal cord with or without tissue clearing. Nat Protoc. 2019 Apr 19; 14:1235-1260. doi: 10.1038/s41596-019-0140-z
Tedeschi A, Dupraz S, Laskowski CJ, Xue J, Ulas T, Beyer M, Schultze JL, Bradke F. The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS. Neuron. 2016 Oct 19; 92:419-434. doi: 10.1016/j.neuron.2016.09.026
Ruschel J, Hellal F, Flynn KC, Dupraz S, Elliott DA, Tedeschi A, Bates M, Sliwinski C, Brook G, Dobrindt K, Peitz M, Brüstle O, Norenberg MD, Blesch A, Weidner N, Bunge MB, Bixby JL, Bradke F. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. Science. 2015 Apr 07; 348:347-52. doi: 10.1126/science.aaa2958


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Patients +49 800-7799001

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Professionals +49 180-779900

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