Axon Growth and Regeneration
Prof. Dr. Frank Bradke
Group Leader
Venusberg-Campus 1, Gebäude 99
(ehemals Sigmund-Freud-Str. 27)
53127 Bonn
 +49 228 43302-688 Sekretariat

Areas of investigation/research focus

Research in the Bradke lab focuses on how nerve cells grow during development and how these processes can be reactivated to induce nerve regeneration in the injured spinal cord.

This laboratory has a special interest in the skeleton of the cell, called the cytoskeleton.

Bradke and his coworkers showed that manipulation of the cytoskeleton with low doses of anticancer drugs leads to regrowth of nerves and reduction of scarring.

His lab also developed a novel imaging technique that enables visualization of nerves at microscopic resolution within whole tissue.

Key Publications

Tedeschi A, Dupraz S, Curcio M, Laskowski CJ, Schaffran B, Flynn KC, Santos TE, Stern S, Hilton BJ, Larson MJE, Gurniak CB, Witke W, Bradke F. ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS. Neuron. 2019 Jul 30; doi: 10.1016/j.neuron.2019.07.007
Hilton BJ, Blanquie O, Tedeschi A, Bradke F. High-resolution 3D imaging and analysis of axon regeneration in unsectioned spinal cord with or without tissue clearing. Nat Protoc. 2019 Apr 19; 14:1235-1260. doi: 10.1038/s41596-019-0140-z
Tedeschi A, Dupraz S, Laskowski CJ, Xue J, Ulas T, Beyer M, Schultze JL, Bradke F. The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS. Neuron. 2016 Oct 19; 92:419-434. doi: 10.1016/j.neuron.2016.09.026
Ruschel J, Hellal F, Flynn KC, Dupraz S, Elliott DA, Tedeschi A, Bates M, Sliwinski C, Brook G, Dobrindt K, Peitz M, Brüstle O, Norenberg MD, Blesch A, Weidner N, Bunge MB, Bixby JL, Bradke F. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. Science. 2015 Apr 07; 348:347-52. doi: 10.1126/science.aaa2958
Flynn KC, Hellal F, Neukirchen D, Jacob S, Tahirovic S, Dupraz S, Stern S, Garvalov BK, Gurniak C, Shaw AE, Meyn L, Wedlich-Söldner R, Bamburg JR, Small JV, Witke W, Bradke F. ADF/cofilin-mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain. Neuron. 2012 Dec 20; 76:1091-107. doi: 10.1016/j.neuron.2012.09.038


Thursdays 1:30-4:30 pm

Patients +49 800-7799001

(free of charge)

Professionals +49 180-779900

(9 Cent/Min. German landline, mobile and out of Germany possibly more expensive)

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