Frank Bradke
Axon Growth and Regeneration
Prof. Dr. Frank Bradke
Group Leader
Venusberg-Campus 1/99
53127  Bonn
 +49 228 43302-688


The complete list of publications is found here.

Santos TE, Schaffran B, Broguière N, Meyn L, Zenobi-Wong M, Bradke F. Axon Growth of CNS Neurons in Three Dimensions Is Amoeboid and Independent of Adhesions. Cell Rep. 2020 Jul 21; 32:107907. doi: 10.1016/j.celrep.2020.107907
Tedeschi A, Dupraz S, Curcio M, Laskowski CJ, Schaffran B, Flynn KC, Santos TE, Stern S, Hilton BJ, Larson MJE, Gurniak CB, Witke W, Bradke F. ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS. Neuron. 2019 Jul 30; doi: 10.1016/j.neuron.2019.07.007
Hilton BJ, Blanquie O, Tedeschi A, Bradke F. High-resolution 3D imaging and analysis of axon regeneration in unsectioned spinal cord with or without tissue clearing. Nat Protoc. 2019 Apr 19; 14:1235-1260. doi: 10.1038/s41596-019-0140-z
Tedeschi A, Dupraz S, Laskowski CJ, Xue J, Ulas T, Beyer M, Schultze JL, Bradke F. The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS. Neuron. 2016 Oct 19; 92:419-434. doi: 10.1016/j.neuron.2016.09.026
Ruschel J, Hellal F, Flynn KC, Dupraz S, Elliott DA, Tedeschi A, Bates M, Sliwinski C, Brook G, Dobrindt K, Peitz M, Brüstle O, Norenberg MD, Blesch A, Weidner N, Bunge MB, Bixby JL, Bradke F. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. Science. 2015 Apr 07; 348:347-52. doi: 10.1126/science.aaa2958
Flynn KC, Hellal F, Neukirchen D, Jacob S, Tahirovic S, Dupraz S, Stern S, Garvalov BK, Gurniak C, Shaw AE, Meyn L, Wedlich-Söldner R, Bamburg JR, Small JV, Witke W, Bradke F. ADF/cofilin-mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain. Neuron. 2012 Dec 20; 76:1091-107. doi: 10.1016/j.neuron.2012.09.038
Ertürk A, Mauch CP, Hellal F, Förstner F, Keck T, Becker K, Jährling N, Steffens H, Richter M, Hübener M, Kramer E, Kirchhoff F, Dodt HU, Bradke F. 3D imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury. Nature Medicine. 2011 Jan 01; 18:166-171.
Hellal F, Hurtado A, Ruschel J, Flynn KC, Laskowski CJ, Umlauf M, Kapitein LC, Strikis D, Lemmon V, Bixby J, Hoogenraad CC, Bradke F. Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury. Science. 2011 Feb 18; 331:928-31. doi: 10.1126/science.1201148
Neukirchen D, Bradke F. Cytoplasmic Linker Proteins Regulate Neuronal Polarization through Microtubule and Growth Cone Dynamics. J Neurosci. 2011 Jan 26; 31:1528-38. doi: 10.1523/JNEUROSCI.3983-10.2011
Enes J, Langwieser N, Ruschel J, Carballosa-Gonzalez MM, Klug A, Traut MH, Ylera B, Tahirovic S, Hofmann F, Stein V, Moosmang S, Hentall ID, Bradke F. Electrical activity suppresses axon growth through Cav1.2 channels in adult primary sensory neurons. Current Biology. 2010 Jul 13; 20:1154-64. doi: 10.1016/j.cub.2010.05.055
Tahirovic S, Hellal F, Neukirchen D, Hindges R, Garvalov BK, Flynn KC, Stradal TE, Chrostek-Grashoff A, Brakebusch C, Bradke F. Rac1 regulates neuronal polarization through the WAVE-complex. J Neurosci. 2010 Feb 19; 30:6930-43. doi: 10.1523/JNEUROSCI.5395-09.2010
Stiess M, Maghelli N, Kapitein LC, Gomis-Rüth S, Wilsch-Bräuninger M, Hoogenraad CC, Tolić-Nørrelykke IM, Bradke F. Axon extension occurs independently of centrosomal microtubule nucleation. Science. 2010 Feb 05; 327:704-7. doi: 10.1126/science.1182179
Ylera B, Ertürk A, Hellal F, Nadrigny F, Hurtado A, Tahirovic S, Oudega M, Kirchhoff F, Bradke F. Chronically injured adult sensory axons in the CNS acquire axon regenerative competence following a lesion of their peripheral process. Current Biology. 2009 Jun 09; 19:930-6. doi: 10.1016/j.cub.2009.04.017
Gomis-Rüth S, Wirenga CJ, Bradke F. Plasticity of polarization: changing dendrites into axons in neurons integrated in neuronal circuits. Current Biology. 2008 Jul 08; 18:992-1000. doi: 10.1016/j.cub.2008.06.026
Witte H, Neukirchen D, Bradke F. Microtubule stabilization specifies initial neuronal polarization. J Cell Biol. 2008 Feb 11; 180:619-32. doi: 10.1083/jcb.200707042


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Professionals +49 180-779900

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