Axonales Wachstum und Regeneration

Prof. Dr. Frank Bradke

Ausgewählte Publikationen

Vinopal, S., Dupraz, S., Alfadil, E., Pietralla, T., Bendre, S., Stiess, M., Falk, S., Camargo Ortega, G., Maghelli, N., Tolić, I. M., Smejkal, J., Götz, M., & Bradke, F. (2023). Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain. Neuron, S0896-6273(23)00070-3

Griffin, J. M., Hingorani Jai Prakash, S., Bockemühl, T., Benner, J. M., Schaffran, B., Moreno-Manzano, V., Büschges, A., & Bradke, F. (2023). Rehabilitation enhances epothilone-induced locomotor recovery after spinal cord injury. Brain communications, 5(1), fcad005. doi.org/10.1093/braincomms/fcad005

Schelski M, Bradke F (2022). Microtubule retrograde flow retains neuronal polarization in a fluctuating state. Sci Adv. 8(44):eabo2336.

Hilton BJ, Husch A, Schaffran B, Lin TC, Burnside ER, Dupraz S, Schelski M, Kim J, Müller A, Schoch S., Imig C, Brose N, Bradke F (2022). An Active Vesicle Priming Machinery Suppresses Axon Regeneration upon Adult CNS Injury. Neuron 110: 51-69.

Stern S, Hilton BJ, Burnside E , Dupraz S , Handley E, Gonyer J, Brakebusch C, Bradke F (2021). RhoA Drives Actin Compaction to Restrict Axon Regeneration and Astrocyte Reactivity after CNS Injury. Neuron 109: 3436-3455.

Santos TE, Schaffran B, Broguière N, Meyn  L, Zenobi-Wong M, Bradke F (2020). Axon Growth of CNS Neurons in Three Dimensions Is Amoeboid and Independent of Adhesions. Cell Rep. 32(3):107907. doi: 10.1016/j.celrep.2020.107907

Tedeschi A, Dupraz S, Curcio M, Laskowski CJ, Schaffran B, Flynn KC, Santos TE, Stern S, Hilton BJ, Larson MJE, Gurniak CB, Witke W, Bradke F (2019). ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS. Neuron 103(6):1073-1085.

Dupraz S, Hilton BJ, Husch A, Santos TE, Coles CH, Stern S, Brakebusch C, Bradke F (2019). RhoA Controls Axon Extension Independent of Specification in the Developing Brain. Curr Biol. 29(22):3874-3886.

Hilton BJ, Blanquie O, Tedeschi A, Bradke F (2019). High-resolution 3D imaging and analysis of axon regeneration in unsectioned spinal cord with or without tissue clearing. Nat Protoc 14(4): 1235-1260.

Tedeschi A, Dupraz S, Laskowski C, Xue J, Ulas T, Beyer M, Schultze J, Bradke F (2016). The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS. Neuron 92: 419–434

Ruschel J, Hellal F, Flynn KC, Dupraz S, Elliott DA, Tedeschi A, Bates M, Sliwinski C, Brook G, Dobrindt K, Peitz M, Brüstle O, Norenberg MD, Blesch A, Weidner N, Bunge MB, Bixby JL, Bradke F (2015). Systemic administration of epothilone B promotes axon regeneration and functional recovery. Science 348: 347-352.

Flynn KC, Hellal F, Neukirchen D, Jacobs S, Tahirovic S, Dupraz S, Stern S,  Garvalov BK, Gurniak C, Shaw A, Meyn L, Wedlich-Söldner R, Bamburg JR, Small JV, Witke W, Bradke F (2012). ADF/cofilin-mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain. Neuron 76:1091-107.

Ertürk A, Mauch CP, Hellal F, Förstner F, Keck T, Becker K, Jährling N, Steffens H, Richter M, Hübener M, Kramer E, Kirchhoff F, Dodt HU, Bradke F (2011). 3D imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury. Nature Medicine 18: 166-171.

Hellal F, Hurtado A, Ruschel J, Flynn KC, Laskowski CJ, Umlauf M, Kapitein LC, Strikis D, Lemmon V, Bixby J, Hoogenraad CC, Bradke F (2011). Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury. Science 331: 928-31.

Stiess M, Maghelli M, Kapitein L, Gomis-Rüth S, Wilsch-Bräuninger M, Hoogenraad CC, Tolić-Nørrelykke IM, Bradke F (2010). Axon extension occurs independently of centrosomal microtubule nucleation. Science 327: 704-707.

 

 

Willkommen auf unserer Webseite, informieren Sie sich hier grundsätzlich cookie-frei.

Wir würden uns freuen, wenn Sie für die Optimierung unseres Informationsangebots ein Cookie zu Analysezwecken zulassen. Alle Daten sind pseudonym und werden nur durch das DZNE verwendet. Wir verzichten bewusst auf Drittanbieter-Cookies. Diese Einstellung können Sie jederzeit hier ändern.

Ihr Browser erlaubt das Setzen von Cookies: