Neurovascular Diseases
Prof. Dr. Gabor Petzold
Group Leader
Venusberg-Campus 1, Gebäude 99
(ehemals Sigmund-Freud-Str. 27)
53127 Bonn

gabor.petzold@dzne.de
 +49 228 43302-684

Areas of investigation/research focus

Our aim is to investigate mechanisms that contribute to neurodegeneration and cognitive impairment in Alzheimer's disease, vascular dementia, and acute stroke. We are particularly interested in the role of astrocytes and the neurovascular unit in these conditions. We use techniques such as multiphoton imaging of cellular network activity in awake behaving animals, complex behavioral tasks, cell-type specific transcriptomics, ultrahigh field MRI, electrophysiology, whole-brain clearing and imaging tools, and computational analyses.

We focus on these topics:

  • Role and functional impact of reactive astrocytes in Alzheimer's disease
  • Role of astrocytes and glial scar formation in the pathophysiology of acute stroke
  • Contribution of neuroinflammation to white matter damage in models of vascular dementia
  • Pathophysiology of cerebral microinfarcts and microhemorrhages in vascular cognitive impairment and Alzheimer's disease
  • Cellular mechanisms contributing to blood-brain barrier dysfunction and neurodegeneration in cerebral amyloid angiopathy
  • Interplay of genetic and acquired risk factors in Alzheimer's disease
  • Ultrahigh field MRI as a preclinical biomarker in normal aging, vascular cognitive impairment and Alzheimer's disease

Informed by the mechanistical insight gleaned from these studies, we also conduct translational and clinical trials focused on the pathophysiology and treatment of acute stroke, small vessel disease, post-stroke dementia and cerebral amyloid angiopathy.

Key Publication

Nicole Reichenbach, Andrea Delekate, Monika Plescher, Franziska Schmitt, Sybille Krauss, Nelli Blank, Annett Halle, Gabor C Petzold. Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model. EMBO Molecular Medicine. 2019 Jan 31; 11 doi: 10.15252/emmm.201809665
Reichenbach N, Delekate A, Breithausen B, Keppler K, Poll S, Schulte T, Peter J, Plescher M, Hansen JN, Blank N, Keller A, Fuhrmann M, Henneberger C, Halle A, Petzold GC. P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model. J Exp Med. 2018 May 03; pii: jem.20171487 [Epub ahead of print] doi: 10.1084/jem.20171487
Cordula Rakers, Gabor C. Petzold. Astrocytic calcium release mediates peri-infarct depolarizations in a rodent stroke model. Journal of Clinical Investigation. 2017 Jan 31; 127:511-516. doi: 10.1172/JCI89354
Andrea Delekate, Martina Füchtemeier, Toni Schumacher, Cordula Ulbrich, Marco Foddis, Gabor C. Petzold. Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer's disease mouse model. Nature Communications. 2013 Dec 31; 5 doi: 10.1038/ncomms6422
Gabor C. Petzold, Venkatesh N. Murthy. Role of astrocytes in neurovascular coupling. Neuron. 2010 Dec 31; 71:782-797. doi: 10.1016/j.neuron.2011.08.009

Info-Hotline

Thursdays 1:30-4:30 pm

Patients +49 800-7799001

(free of charge)

Professionals +49 180-779900

(9 Cent/Min. German landline, mobile and out of Germany possibly more expensive)

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