MR Physics
Prof. Dr. Tony Stöcker
Group Leader
Venusberg-Campus 1, Gebäude 99
(ehemals Sigmund-Freud-Str. 27)
53127 Bonn

tony.stoecker@dzne.de
 +49 228 43302-860

Areas of investigation/research focus

The research group MR Physics investigates novel medical imaging methods for preclinical biomarkers of neurodegenerative diseases. The early detection of neurodegenerative diseases using medical imaging techniques is a challenging and still unsolved task. Nevertheless, Magnetic Resonance Imaging (MRI) is the method of choice due to its inherently multi-modal character: MRI exploits many different biophysical and biochemical properties and provides quantitative information for brain tissue characterization. Furthermore, the noninvasive nature of MRI offers a great opportunity to perform large-scale longitudinal studies in patient groups as well as in healthy volunteers. However, it is very difficult to detect small changes in brain tissue, as they occur in neurodegeneration.

 more Infos

Our main focus is the MRI sequence development on a new state-of-the-art 7 Tesla human MRI scanner, allowing the manifestations of neurodegeneration to be probed with high sensitivity and resolution. The higher sensitivity of ultra-high magnetic field MRI brings the opportunity to detect subtle changes in brain function, structure, and metabolism as known to be present in early stages of neurodegenerative diseases. The accompanied challenges of ultra-high field MRI are an active and important area of basic physics research.

Another major integral part of our work is the scientific support of high-throughput and high-quality neuroimaging at clinical 3 Tesla MRI scanners in the context of large-scale patient and population studies. The MR Physics group developed novel fast imaging techniques in collaboration with population science and clinical science at the DZNE. We developed the one-hour imaging protocol of the Rhineland Study which is now utilized in the main study. It includes novel acquisition methods for anatomical brain images, functional connectivity, structural connectivity, and imaging of vasculature. Additional, one of several contrasts, such as brain perfusion or macromolecule quantification, is obtained in a free protocol. The newly developed methods are additionally applied in studies together with partners from DZNE clinical science and international collaborators.

Key Publications

Ehses P, Brenner D, Stirnberg R, Pracht ED, Stöcker T. Whole-brain B1-mapping using three-dimensional DREAM. Magnetic Resonance in Medicine. 2019 Apr 30; 82:924-934. doi: 10.1002/mrm.27773
Akbey S, Ehses P, Stirnberg R, Zaiss M, Stöcker T. Snapshot Whole-Brain CEST Imaging at 7T Using Centric-Reordered 3D-EPI. Magnetic Resonance in Medicine. 2019 Jun 14; 82:1741-1752. doi: 10.1002/mrm.27866
Tobisch A, Stirnberg R, Harms R, Schultz T, Roebroeck A, Breteler M, Stöcker T. Compressed Sensing Diffusion Spectrum Imaging for Accelerated Diffusion Microstructure MRI in Long-Term Population Imaging. Frontiers in Neuroscience. 2018 Sep 24; 12:650. doi: 10.3389/fnins.2018.00650
Rüdiger Stirnberg, Willem Huijbers, Daniel Brenner, Benedikt A. Poser, Monique Breteler, Tony Stöcker. Rapid whole-brain resting-state fMRI at 3 T: Efficiency-optimized three-dimensional EPI versus repetition time-matched simultaneous-multi-slice EPI. NeuroImage. 2017 Nov 30; 163:81-92. doi: 10.1016/j.neuroimage.2017.08.031
Pracht ED, Feiweier T, Ehses P, Brenner D, Roebroeck A, Weber B, Stöcker T. SAR and Scan Time Optimized 3D Whole Brain Double Inversion Recovery Imaging at 7T. Magnetic Resonance in Medicine. 2017 Jan 01; doi: 10.1002/mrm.26913

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