Innate Immunity in Neurodegeneration
Prof. Dr. Eicke Latz
Prof. Latz is Director of Institute of Innate Immunity at the University of Bonn
+49 228 287-51223
Many common diseases in modern societies are associated with an overactive innate immune system and chronic inflammation is part of the pathogenesis of the majority of non-communicable diseases. Our major research aims are:
- We focus on deciphering the molecular mechanisms of innate immune receptor activation using pharmacologic, biochemical and structural approaches.
- We are particularly interested in understanding how innate receptors interact with their ligands leading to the most proximal signaling events.
- We study the mechanisms by which cells sense nucleic acids and sterile danger signals by intracellular multi-molecular signaling complexes, termed inflammasomes.
- We are investigating how innate immune activation contributes to the inflammatory responses in various conditions, such as atherosclerosis, Alzheimer’s disease, chronic eye diseases as well as metabolic diseases.
- We perform a deep immune phenotyping analysis of the human immune system and perform functional genomics studies to elucidate novel mechanisms of immune activation and susceptibility to major inflammatory diseases.
Sebastian Zimmer, Alena Grebe, Siril S. Bakke, Niklas Bode, Bente Halvorsen, Thomas Ulas, Mona Skjelland, Dominic De Nardo, Larisa I. Labzin, Anja Kerksiek, Chris Hempel, Michael T. Heneka, Victoria Hawxhurst, Michael L. Fitzgerald, Jonel Trebicka, Ingemar Björkhem, Jan-Åke Gustafsson, Marit Westerterp, Alan R. Tall, Samuel D. Wright, Terje Espevik, Joachim L. Schultze, Georg Nickenig, Dieter Lütjohann, Eicke Latz. Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Science Translational Medicine. 2016 Apr 05; 8 doi: 10.1126/scitranslmed.aad6100
Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E. The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation. Nat Immunol. 2014 Aug 01; 15:727-37. doi: 10.1038/ni.2913
De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, …, Latz E. HDL mediates antiinflammatory transcriptional reprogramming of macrophages via ATF3. Nat Immunol. 2014 Jan 01; 15:152-60. doi: 10.1038/ni.2784
Michael T. Heneka, Markus P. Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng, Ellen Gelpi, Annett Halle, Martin Korte, Eicke Latz, Douglas T. Golenbock. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. 2013 Feb 06; 494:674-678.
Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol. 2008 Jan 01; 9:847-56. doi: 10.1038/ni.1631