Translational Dementia Research
Prof. Dr. Anja Schneider
Group Leader
Sigmund-Freud-Str. 27
53127 Bonn

anja.schneider@dzne.de
 +49 228 43302-450

Areas of investigation/research focus

We investigate extracellular vesicles (EVs) in neurodegenerative diseases. We are especially interested in EV mediated release of toxic, aggregated proteins, such as a-Synuclein, the determinants of their sorting into EVs and the contribution of their release to toxicity and propagation of disease pathology throughout the brain. We also explore physiological functions of EVs in the CNS, e.g. the effects of oligodendroglial EVs, using primary cell culture and mouse models. Furthermore, we are interested in oligodendroglial pathology in neurodegenerative diseases.

In addition, we are focus on the detection of novel biomarkers from blood and cerebrospinal fluid (CSF) which may enable diagnosis and prognosis of neurodegenerative diseases in the prodromal or even preclinical stage.

 more Infos

An important aspect of our work is the translation from basic research to clinical application and vice versa.

Clinical research

One example of translation from basic research into clinical application within the DZNE is our currently recruiting phase Ib trial testing the safety and tolerability of Vorinostat in patients with mild Alzheimer’s disease. We set up the study protocol based on findings by A. Fischer’s group at DZNE Göttingen showing that Vorinostat can reinstate memory deficits in an  Alzheimer’s disease mouse model.

Key Publications

Bartels C, Wolfsgruber S, Wagner M, Ehrenreich H, Schneider A. Impact of selective serotonin reuptake inhibitor therapy on risk of conversion from mild cognitive impairment to Alzheimer’s dementia in individuals with previous depression. Am J Psychiatry. 2017 Nov 28; doi: 10.1176/appi.ajp.2017.17040404
Anne Stuendl, Marcel Kunadt, Niels Kruse, Claudia Bartels, Wiebke Moebius, Karin M. Danzer, Brit Mollenhauer, Anja Schneider. Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies. Brain. 2016 Jan 31; 139:481-494. doi: 10.1093/brain/awv346
Kunadt M, Eckermann K, Strauss K, Rai S, Kügler S, Stündl A, Lockhart LF, Schwalbe M, Krumova P, Oliveira L, Bähr M, Möbius W, Ludolph AC, Levin J, Giese A, Kruse N, Mollenhauer B, Geiss-Friedlander R, Freischmidt A, Feiler M, Danzer KM, Zweckstetter M, Jovin T, Simons M, Weishaupt JH, Schneider A. Sumoylation regulates exosomal sorting of -Synuclein for extracellular release. Acta Neuropathologica. 2015 May 01; 129:695-713. doi: 10.1007/s00401-015-1408-1
Strauss K., Goebels C., Moebius W., Weiss S., Runz H., Feussner I., Simons M., Schneider A. Exosome secretion bypasses lysosomal storage of cholesterol in Niemann-Pick type C disease. J Biol Chem. 2010 Aug 20; 285:26279-88.
Rajendran L., Schneider A., Schlechtingen G., Weidlich S., Ries J., Braxmeier T., Schwille P., Schulz J.B., Schroeder C., Simons M., Jennings G., Knoelker H.J., Simons K. Efficient inhibition of the Alzheimer’s disease β-secretase by membrane targeting. Science. 2008 Apr 25; 320:520-3.

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