Parkinson Genetik
Prof. Dr. Thomas Gasser
Leiter der Klinischen Forschung
am Standort Tübingen,
Gruppenleiter
Vorstandsmitglied des Hertie-Instituts für klinische Hirnforschung
Hoppe-Seyler-Str. 3
72076 Tübingen

thomas.gasser@dzne.de
 +49 7071 29-86529

Publikationen

Die vollständige Publikationsliste findet man hier.

David C. Schöndorf, Dina Ivanyuk, Pascale Baden, Alvaro Sanchez-Martinez, Silvia De Cicco, Cong Yu, Ivana Giunta, Lukas K. Schwarz, Gabriele Di Napoli, Vasiliki Panagiotakopoulou, Sigrun Nestel, Marcus Keatinge, Jan Pruszak, Oliver Bandmann, Bernd Heimrich, Thomas Gasser, Alexander J. Whitworth, Michela Deleidi. The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease. Cell Reports. 2018 Jun 04; 23:2976-2988. doi: 10.1016/j.celrep.2018.05.009
Aree Witoelar, Iris E. Jansen, Yunpeng Wang, Rahul S. Desikan, J. Raphael Gibbs, Cornelis Blauwendraat, Wesley K. Thompson, Dena G. Hernandez, Srdjan Djurovic, Andrew J. Schork, Francesco Bettella, David Ellinghaus, Andre Franke, Benedicte A. Lie, Linda K. McEvoy, Tom H. Karlsen, Suzanne Lesage, Huw R. Morris, Alexis Brice, Nicholas W. Wood, Peter Heutink, John Hardy, Andrew B. Singleton, Anders M. Dale, Thomas Gasser, Ole A. Andreassen, Manu Sharma, Michael A. Nalls, Vincent Plagnol, Una-Marie Sheerin, Mohamad Saad, Javier Simon-Sanchez, Claudia Schulte, Sigurlaug Sveinbjornsdottir, Sampath Arepalli, Roger Barker, Yoav Ben-Shlomo, Henk W. Berendse, Daniela Berg, Kailash Bhatia, Rob M.A. De Bie, Alessandro Biffi, Bas Bloem, Zoltan Bochdanovits, Michael Bonin, Jose M. Bras, Kathrin Brockmann, Janet Brooks, David J. Burn, Elisa Majounie, Gavin Charlesworth, Codrin Lungu, Honglei Chen, Patrick F. Chinnery, Sean Chong, Carl E. Clarke, Mark R. Cookson, J. Mark Cooper, Jean Christophe Corvol, Carl Counsell, Philippe Damier, Jean-Francois Dartigues, Panos Deloukas, Gunther Deuschl, David T. Dexter, Karin D. Van Dijk, Allissa Dillman, Frank Durif, Alexandra Durr, Sarah Edkins, Jonathan R. Evans, Thomas Foltynie, Jing Dong, Michelle Gardner, Alison Goate, Emma Gray, Rita Guerreiro, Clare Harris, Jacobus J. Van Hilten, Albert Hofman, Albert Hollenbeck, Janice Holton, Michele Hu, Xuemei Huang, Isabel Wurster, Walter Matzler, Gavin Hudson, Sarah E. Hunt, Johanna Huttenlocher, Thomas Illig, Palmi V. Jonsson, Jean-Charles Lambert, Cordelia Langford, Andrew Lees, Peter Lichtner, Patricia Limousin, Grisel Lopez, Delia Lorenz, Alisdair McNeill, Catriona Moorby, Matthew Moore, Karen E. Morrison, Valentina Escott-Price, Ese Mudanohwo, Sean S. O'Sullivan, Justin Pearson, Joel S. Perlmutter, Hjorvar Petursson, Pierre Pollak, Bart Post, Simon Potter, Bernard Ravina, Tamas Revesz, Olaf Riess, Fernando Rivadeneira, Patrizia Rizzu, Mina Ryten, Stephen Sawcer, Anthony Schapira, Hans Scheffer, Karen Shaw, Ira Shoulson, Joshua Shulman, Ellen Sidransky, Colin Smith, Chris C.A. Spencer, Hreinn Stefansson, Joanna D. Stockton, Amy Strange, Kevin Talbot, Carlie M. Tanner, Avazeh Tashakkori-Ghanbaria, Francois Tison, Daniah Trabzuni, Bryan J. Traynor, Andre G. Uitterlinden, Daan Velseboer, Marie Vidailhet, Robert Walker, Bart Van De Warrenburg, Mirdhu Wickremaratchi, Nigel Williams, Caroline H Williams-Gray, Sophie Winder-Rhodes, Kari Stefansson, Maria Martinez, Luigi Ferrucci, Robert Johnson, Dan L. Longo, Michael A. Nalls, Richard O'Brien, Juan Troncoso, Marcel Van Der Brug, H. Ronald Zielke, Alan Zonderman, John A. Hardy, Mike Weale. Genome-wide pleiotropy between Parkinson disease and autoimmune diseases. JAMA Neurology. 2017 Jun 30; 74:780-792. doi: 10.1001/jamaneurol.2017.0469
Fitzgerald JC, Zimprich A, Berrio DAC, Schindler KM, Maurer B, Schulte C, Bus C, Hauser AK, Kubler M, Lewin R, Bobbili DR, Schwarz LM, Vartholomaiou E, Brockmann K, Wust R, Madlung J, Nordheim A, Riess O, Martins LM, Glaab E, May P, Schenke-Layland K, Picard D, Sharma M, Gasser T, Kruger R. Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease. Brain. 2017 Jan 01; 140 doi: 10.1093/brain/awx202
Postuma RB, Berg D, Adler CH, Bloem BR, Chan P, Deuschl G, Gasser T, Goetz CG, Halliday G, Joseph L, Lang AE, Liepelt-Scarfone I, Litvan I, Marek K, Oertel W, Olanow CW, Poewe W, Stern M. The new definition and diagnostic criteria of Parkinson's disease. Lancet Neurol. 2016 Jan 01; 15:546-8. doi: 10.1016/s1474-4422(16)00116-2
Gasser T. Personalized Medicine Approaches in Parkinson's Disease: The Genetic Perspective. J Parkinsons Dis. 2016 Jan 01; 6:699-701. doi: 10.3233/jpd-160876
Gasser T. Usefulness of Genetic Testing in PD and PD Trials: A Balanced Review. J Parkinsons Dis. 2015 Jan 01; 5:209-15. doi: 10.3233/jpd-140507
David C. Schöndorf, Massimo Aureli, Fiona E. McAllister, Christopher J. Hindley, Florian Mayer, Benjamin Schmid, S. Pablo Sardi, Manuela Valsecchi, Susanna Hoffmann, Lukas Kristoffer Schwarz, Ulrike Hedrich, Daniela Berg, Lamya S. Shihabuddin, Jing Hu, Jan Pruszak, Steven P. Gygi, Sandro Sonnino, Thomas Gasser, Michela Deleidi. IPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis. Nature Communications. 2014 Jun 05; 5 doi: 10.1038/ncomms5028
Reinhardt P, Schmid B, Burbulla LF, Schondorf DC, Wagner L, ..., Gasser T, et al. Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression. Cell Stem Cell. 2013 Jan 01; 12:354-67. doi: 10.1016/j.stem.2013.01.008
Michael A. Nalls, Vincent Plagnol, Dena G. Hernandez, Manu Sharma, Una-Marie Sheerin, Mohamad Saad, Simón-Sánchez, Claudia Schulte, Suzanne Lesage, Sigurlaug Sveinbjörnsdóttir, Kári Stefánsson, Maria Martinez, John Hardy, Peter Heutink, Alexis Brice, Thomas Gasser, Andrew B. Singleton, Nicholas W. Wood. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: A meta-analysis of genome-wide association studies. The Lancet. 2010 Dec 31; 377:641-649. doi: 10.1016/S0140-6736(10)62345-8
Katja Lohmann, Alexander Schmidt, Arne Schillert, Susen Winkler, Alberto Albanese, Frank Baas, Anna Rita Bentivoglio, Friederike Borngräber, Norbert Brüggemann, Giovanni Defazio, Francesca Del Sorbo, Günther Deuschl, Mark J. Edwards, Thomas Gasser, Pilar Gómez-Garre, Julia Graf, Justus L. Groen, Anne Grünewald, Johann Hagenah, Claudia Hemmelmann, Hans-Christian Jabusch, Ryuji Kaji, Meike Kasten, Hideshi Kawakami, Vladimir S. Kostic, Maria Liguori, Pablo Mir, Alexander Münchau, Felicia Ricchiuti, Stefan Schreiber, Katharina Siegesmund, Marina Svetel, Marina A.J. Tijssen, Enza Maria Valente, Ana Westenberger, Kirsten E. Zeuner, Simone Zittel, Eckart Altenmüller, Andreas Ziegler, Christine Klein. Genome-wide association study in musician's dystonia: A risk variant at the arylsulfatase G locus?. Movement Disorders. 2013 Dec 31; 29:921-927. doi: 10.1002/mds.25791
Sidransky E, Nalls MA, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER, Bar-Shira A, Berg D, Bras J, Brice A, Chen CM, Clark LN, Condroyer C, De Marco EV, Durr A, Eblan MJ, Fahn S, Farrer MJ, Fung HC, Gan-Or Z, Gasser T, Gershoni-Baruch R, Giladi N, Griffith A, Gurevich T, Januario C, Kropp P, Lang AE, Lee-Chen GJ, Lesage S, Marder K, Mata IF, Mirelman A, Mitsui J, Mizuta I, Nicoletti G, Oliveira C, Ottman R, Orr-Urtreger A, Pereira LV, Quattrone A, Rogaeva E, Rolfs A, Rosenbaum H, Rozenberg R, Samii A, Samaddar T, Schulte C, Sharma M, Singleton A, et al. Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease. N Engl J Med. 2009 Jan 01; 361:1651-61. doi: 10.1056/NEJMoa0901281
Mueller JC, Fuchs J, Hofer A, Zimprich A, Lichtner P, Illig T, Berg D, Wullner U, Meitinger T, Gasser T. Multiple regions of alpha-synuclein are associated with Parkinson's disease. Ann Neurol. 2005 Jan 01; 57:535-41. doi: 10.1002/ana.20438
erg D, Schweitzer KJ, Leitner P, Zimprich A, Lichtner P, Belcredi P, Brussel T, Schulte C, Maass S, Nagele T, Wszolek ZK, Gasser T. Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease. Brain. 2005 Jan 01; 128:3000-11. doi: 10.1093/brain/awh666
Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, Kachergus J, Hulihan M, Uitti RJ, Calne DB, Stoessl AJ, Pfeiffer RF, Patenge N, Carbajal IC, Vieregge P, Asmus F, Müller-Myhsok B, Dickson DW, Meitinger T, Strom TM, Wszolek ZK, Gasser T. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron. 2004 Nov 18; 44:601-7. doi: 10.1016/j.neuron.2004.11.005
Zimprich A, Grabowski M, Asmus F, Naumann M, Berg D, Bertram M, Scheidtmann K, Kern P, Winkelmann J, Müller-Myhsok B, Riedel L, Bauer M, Müller T, Castro M, Meitinger T, Strom TM, Gasser T. Mutations in the gene encoding epsilon-sarcoglycan cause myoclonus-dystonia syndrome. Nat Genet. 2001 Sep 01; 29:66-9. doi: 10.1038/ng709

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