Thomas Gasser
Parkinson Genetics
Prof. Dr. Thomas Gasser
Head of clinical research Tübingen,
Group Leader
Hoppe-Seyler-Str. 3
72076 Tübingen

thomas.gasser@dzne.de
 +49 7071 29-86529

Publications

The complete list of publications is found here.

David C. Schöndorf, Dina Ivanyuk, Pascale Baden, Alvaro Sanchez-Martinez, Silvia De Cicco, Cong Yu, Ivana Giunta, Lukas K. Schwarz, Gabriele Di Napoli, Vasiliki Panagiotakopoulou, Sigrun Nestel, Marcus Keatinge, Jan Pruszak, Oliver Bandmann, Bernd Heimrich, Thomas Gasser, Alexander J. Whitworth, Michela Deleidi. The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease. Cell Reports. 2018 Jun 04; 23:2976-2988. doi: 10.1016/j.celrep.2018.05.009
Aree Witoelar, Iris E. Jansen, Yunpeng Wang, Rahul S. Desikan, J. Raphael Gibbs, Cornelis Blauwendraat, Wesley K. Thompson, Dena G. Hernandez, Srdjan Djurovic, Andrew J. Schork, Francesco Bettella, David Ellinghaus, Andre Franke, Benedicte A. Lie, Linda K. McEvoy, Tom H. Karlsen, Suzanne Lesage, Huw R. Morris, Alexis Brice, Nicholas W. Wood, Peter Heutink, John Hardy, Andrew B. Singleton, Anders M. Dale, Thomas Gasser, et al. Genome-wide pleiotropy between Parkinson disease and autoimmune diseases. JAMA Neurology. 2017 Jun 30; 74:780-792. doi: 10.1001/jamaneurol.2017.0469
Fitzgerald JC, Zimprich A, Berrio DAC, Schindler KM, Maurer B, Schulte C, Bus C, Hauser AK, Kubler M, Lewin R, Bobbili DR, Schwarz LM, Vartholomaiou E, Brockmann K, Wust R, Madlung J, Nordheim A, Riess O, Martins LM, Glaab E, May P, Schenke-Layland K, Picard D, Sharma M, Gasser T, Kruger R. Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease. Brain. 2017 Jan 01; 140 doi: 10.1093/brain/awx202
Postuma RB, Berg D, Adler CH, Bloem BR, Chan P, Deuschl G, Gasser T, Goetz CG, Halliday G, Joseph L, Lang AE, Liepelt-Scarfone I, Litvan I, Marek K, Oertel W, Olanow CW, Poewe W, Stern M. The new definition and diagnostic criteria of Parkinson's disease. Lancet Neurol. 2016 Jan 01; 15:546-8. doi: 10.1016/s1474-4422(16)00116-2
Gasser T. Personalized Medicine Approaches in Parkinson's Disease: The Genetic Perspective. J Parkinsons Dis. 2016 Jan 01; 6:699-701. doi: 10.3233/jpd-160876
Gasser T. Usefulness of Genetic Testing in PD and PD Trials: A Balanced Review. J Parkinsons Dis. 2015 Jan 01; 5:209-15. doi: 10.3233/jpd-140507
David C. Schöndorf, Massimo Aureli, Fiona E. McAllister, Christopher J. Hindley, Florian Mayer, Benjamin Schmid, S. Pablo Sardi, Manuela Valsecchi, Susanna Hoffmann, Lukas Kristoffer Schwarz, Ulrike Hedrich, Daniela Berg, Lamya S. Shihabuddin, Jing Hu, Jan Pruszak, Steven P. Gygi, Sandro Sonnino, Thomas Gasser, Michela Deleidi. IPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis. Nature Communications. 2014 Jun 05; 5 doi: 10.1038/ncomms5028
Reinhardt P, Schmid B, Burbulla LF, Schondorf DC, Wagner L, ..., Gasser T, et al. Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression. Cell Stem Cell. 2013 Jan 01; 12:354-67. doi: 10.1016/j.stem.2013.01.008
Michael A. Nalls, Vincent Plagnol, Dena G. Hernandez, Manu Sharma, Una-Marie Sheerin, Mohamad Saad, Simón-Sánchez, Claudia Schulte, Suzanne Lesage, Sigurlaug Sveinbjörnsdóttir, Kári Stefánsson, Maria Martinez, John Hardy, Peter Heutink, Alexis Brice, Thomas Gasser, Andrew B. Singleton, Nicholas W. Wood. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: A meta-analysis of genome-wide association studies. The Lancet. 2010 Dec 31; 377:641-649. doi: 10.1016/S0140-6736(10)62345-8
Simon-Sanchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, …, Gasser T. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet. 2009 Jan 01; 41:1308-12. doi: 10.1038/ng.487
Sidransky E, Nalls MA, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER, Bar-Shira A, Berg D, Bras J, Brice A, Chen CM, Clark LN, Condroyer C, De Marco EV, Durr A, Eblan MJ, Fahn S, Farrer MJ, Fung HC, Gan-Or Z, Gasser T, Gershoni-Baruch R, Giladi N, Griffith A, Gurevich T, Januario C, Kropp P, Lang AE, Lee-Chen GJ, Lesage S, Marder K, Mata IF, Mirelman A, Mitsui J, Mizuta I, Nicoletti G, Oliveira C, Ottman R, Orr-Urtreger A, Pereira LV, Quattrone A, Rogaeva E, Rolfs A, Rosenbaum H, Rozenberg R, Samii A, Samaddar T, Schulte C, Sharma M, Singleton A, et al. Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease. N Engl J Med. 2009 Jan 01; 361:1651-61. doi: 10.1056/NEJMoa0901281
Mueller JC, Fuchs J, Hofer A, Zimprich A, Lichtner P, Illig T, Berg D, Wullner U, Meitinger T, Gasser T. Multiple regions of alpha-synuclein are associated with Parkinson's disease. Ann Neurol. 2005 Jan 01; 57:535-41. doi: 10.1002/ana.20438
erg D, Schweitzer KJ, Leitner P, Zimprich A, Lichtner P, Belcredi P, Brussel T, Schulte C, Maass S, Nagele T, Wszolek ZK, Gasser T. Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease. Brain. 2005 Jan 01; 128:3000-11. doi: 10.1093/brain/awh666
Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, Kachergus J, Hulihan M, Uitti RJ, Calne DB, Stoessl AJ, Pfeiffer RF, Patenge N, Carbajal IC, Vieregge P, Asmus F, Müller-Myhsok B, Dickson DW, Meitinger T, Strom TM, Wszolek ZK, Gasser T. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron. 2004 Nov 18; 44:601-7. doi: 10.1016/j.neuron.2004.11.005
Zimprich A, Grabowski M, Asmus F, Naumann M, Berg D, Bertram M, Scheidtmann K, Kern P, Winkelmann J, Müller-Myhsok B, Riedel L, Bauer M, Müller T, Castro M, Meitinger T, Strom TM, Gasser T. Mutations in the gene encoding epsilon-sarcoglycan cause myoclonus-dystonia syndrome. Nat Genet. 2001 Sep 01; 29:66-9. doi: 10.1038/ng709

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