Parkinson Genetics
Prof. Dr. Thomas Gasser
Head of clinical research Tübingen,
Group Leader
Hoppe-Seyler-Str. 3
72076 Tübingen

thomas.gasser@dzne.de
 +49 7071 29-86529

Areas of investigation/research focus

The group of Prof. Gasser focuses on the study of Parkinson's syndrome, which is the second most common neurodegenerative disease after Alzheimer's disease with demographically steadily increasing prevalence. The group deals with the analysis of genetic factors that play a role in Parkinson's disease and with the question of which proteins are involved in onset and progression of Parkinson's disease.

The genetic variants known today can only explain a small part of the overall risk of the disease. In order to obtain a more complete picture of the entire genetic risk profile and to derive new approaches for diagnosis, prevention or therapy, as complete genetic data sets as possible must be examined by many thousands of patients. In large international consortia, such as the International Parkinson's Disease Genomics Consortium (IPDGC), the research group conducts such studies in collaboration with many colleagues from around the world.

Key Publications

Reinhardt P, Schmid B, Burbulla LF, Schondorf DC, Wagner L, ..., Gasser T, et al. Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression. Cell Stem Cell. 2013 Jan. 01; 12:354-67. doi: 10.1016/j.stem.2013.01.008
Michael A. Nalls, Vincent Plagnol, Dena G. Hernandez, Manu Sharma, Una-Marie Sheerin, Mohamad Saad, Simón-Sánchez, Claudia Schulte, Suzanne Lesage, Sigurlaug Sveinbjörnsdóttir, Kári Stefánsson, Maria Martinez, John Hardy, Peter Heutink, Alexis Brice, Thomas Gasser, Andrew B. Singleton, Nicholas W. Wood. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: A meta-analysis of genome-wide association studies. The Lancet. 2011 Feb. 18; 377:641-649. doi: 10.1016/S0140-6736(10)62345-8
Simon-Sanchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, …, Gasser T. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet. 2009 Jan. 01; 41:1308-12. doi: 10.1038/ng.487
Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, Kachergus J, Hulihan M, Uitti RJ, Calne DB, Stoessl AJ, Pfeiffer RF, Patenge N, Carbajal IC, Vieregge P, Asmus F, Müller-Myhsok B, Dickson DW, Meitinger T, Strom TM, Wszolek ZK, Gasser T. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron. 2004 Nov. 18; 44:601-7. doi: 10.1016/j.neuron.2004.11.005
Zimprich A, Grabowski M, Asmus F, Naumann M, Berg D, Bertram M, Scheidtmann K, Kern P, Winkelmann J, Müller-Myhsok B, Riedel L, Bauer M, Müller T, Castro M, Meitinger T, Strom TM, Gasser T. Mutations in the gene encoding epsilon-sarcoglycan cause myoclonus-dystonia syndrome. Nat Genet. 2001 Sep. 01; 29:66-9. doi: 10.1038/ng709

Info-Hotline

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