Translationale Forschung in Neurodegeneration
Prof. Dr. Dr. Andreas Hermann
Leiter der Klinischen Forschung
am Standort Dresden,
Gruppenleiter
Fetscherstr. 74
01307 Dresden

andreas.hermann@dzne.de
 +49 351 458-2532

Forschungsschwerpunkte

Areas of investigation/research focus

A main focus of the Clinical Cooperation Unit is the bidirectional translation between basic science and clinical patient work, including human patient-derived iPSC cultures, drug development, biomarker development (MRI markers and behavioral endophenotypes); characterization of prodromal states of neurodegeneration and clinical correlation of spreading of disease pathology including non motor symptoms in neurodegenerative diseases. Future direction will more and more involve work on healthy aging including modes and mechanisms of disease converions from prodromal stages or interventions to avoid secondary aging.

Behavioural Endophenotypes of different neurodegenerative diseases

We analyse the differential involvement of hippocampal degeneration and brain network impairment in different forms of aphasie (lesional vs. degenerative aphasia) and the influece of the lack of movement on hippocampal function (due to paralysis in motor neuron disease). For this we use the Dresden Spatial Navigation Task (DSNT), a virtual version of the classical water maze task designed and validated in animal studies. This is done in close colaboration with the Kempermann group at the DZNE site Dresden. Additionally we use neurophysiology techniques (event-related potentials) in collaboration with the Prof. Beste group in Dresden. 

Palliative and patient-centered care in advanced neurodegeneration

Patient-centered care is another focus of our group also involving joint activities within DZNE (e.g. Interside project of next-of-kins studies of FTD patients). Using computer-based communication techniques including eye-tracking systems we investigate the Quality of Life (QoL) of such advanced patients and the influence of health care and public mains on the QoL of patients and their next of kins as well as the influence on decicion making towards live prolonging procedures.

Human cell models of neurodegeneration

The basic science DZNE group focus on the establishment of a resource of hypothesis-matched cell models: a panel of patient-specific iPS cells together with improved protocols for the derivation of disease-relevant cell types. Mitochondrial/energy (dys-)metabolism and axonopathy in ALS/FTD and further neurodegenerative diseases (HD, PD, forms of neuropathies) have become further important areas of basic research of our group. Beside the “reverse translation” (from clinic to basic research), we pursue the aim of “forward translation” with regard to drug screening/development and improved diagnostic procedures with the main focus on unraveling the pathophysiology of the underlying neurodegenerative disease.

Schlüsselpublikationen

Linse K, Rüger W, Joos M, Schmitz-Peiffer H, Storch A, Hermann A. Eyetracking-based assessment suggests preserved wellbeing in locked-in patients. Ann Neurol. 2017 Jan 01; 81:310-315. doi: 10.1002/ana.24871
Julia Japtok, Xenia Lojewksi, Marcel Naumann, Moritz Klingenstein, Peter Reinhardt, Jared Sterneckert, Stefan Putz, Maria Demestre, Tobias M. Boeckers, Albert C. Ludolph, Stefan Liebau, Alexander Storch, Andreas Hermann. Stepwise acquirement of hallmark neuropathology in FUS-ALS iPSC models depends on mutation type and neuronal aging. Neurobiology of Disease. 2015 Sep 30; 82:420-429. doi: 10.1016/j.nbd.2015.07.017
Xenia Lojewski, John F. Staropoli, Sunita Biswas-legrand, Alexandra M. Simas, Larissa Haliw, Martin K. Selig, Scott H. Coppel, Kendrick A. Goss, Anton Petcherski, Uma Chandrachud, Steven D. Sheridan, Diane Lucente, Katherine B. Sims, James F. Gusella, Dolan Sondhi, Ronald G. Crystal, Peter Reinhardt, Jared Sterneckert, Hans Schöler, Stephen J. Haggarty, Alexander Storch, Andreas Hermann, Susan L. Cotman. Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway. Human Molecular Genetics. 2014 Mar 31; 23:2005-2022. doi: 10.1093/hmg/ddt596
Dong Wook Han, Natalia Tapia, Andreas Hermann, Kathrin Hemmer, Susanne Höing, Marcos J. Araúzo-Bravo, Holm Zaehres, Guangming Wu, Stefan Frank, Sören Moritz, Boris Greber, Ji Hun Yang, Hoon Taek Lee, Jens C. Schwamborn, Alexander Storch, Hans R. Schöler. Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell. 2012 Apr 05; 10:465-472. doi: 10.1016/j.stem.2012.02.021
Hermann A, Gastl R, Liebau S, Popa MO, Fiedler J, Boehm BO, et al. Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells. J Cell Sci. 2004 Sep 01; 117:4411-4422. doi: 10.1242/jcs.01307

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