Andreas Hermann
Translational Neurodegeration
Prof. Dr. Dr. Andreas Hermann
Group Leader
Head of Section Translational Neurodegeneration "Albrecht Kossel" of the Clinic and Polyclinic for Neurology, University Medical Center Rostock
Gehlsheimer Str. 20
18147 Rostock

andreas.hermann@dzne.de
 +49 381 494-9541

Areas of investigation/research focus

A main focus of the working group is the bidirectional translation between basic science and clinical patient work, including human patient-derived iPSC cultures, drug development, biomarker development (wet markers, MRI markers, PET markers and behavioral endophenotypes); characterization of prodromal states of neurodegeneration and clinical correlation of spreading of disease pathology including non motor symptoms in neurodegenerative diseases. Future direction will more and more involve work on healthy and diseased aging including modes and mechanisms of disease converions from prodromal stages or interventions to avoid secondary aging.

Palliative and patient-centered care in advanced neurodegeneration

Patient-centered care is another focus of our group also involving joint activities within DZNE (e.g. Interside project of next-of-kins studies of FTD patients). Using computer-based communication techniques including eye-tracking systems we investigate the Quality of Life (QoL) of such advanced patients and the influence of health care and public mains on the QoL of patients and their next of kins as well as the influence on decision making towards live prolonging procedures.

Human cell models of neurodegeneration

The basic science DZNE group focus on the establishment of a resource of hypothesis-matched cell models: a panel of patient-specific iPS cells together with improved protocols for the derivation of disease-relevant cell types. Mitochondrial/energy (dys-)metabolism and axonopathy in ALS/FTD and further neurodegenerative diseases (HD, PD, forms of neuropathies) have become further important areas of basic research of our group. Beside the “reverse translation” (from clinic to basic research), we pursue the aim of “forward translation” with regard to drug screening/development and improved diagnostic procedures with the main focus on unraveling the pathophysiology of the underlying neurodegenerative disease.

Key Publications

Marcel Naumann, Arun Pal, Anand Goswami, Xenia Lojewski, Julia Japtok, Anne Vehlow, Maximilian Naujock, René Günther, Mengmeng Jin, Nancy Stanslowsky, Peter Reinhardt, Jared Sterneckert, Marie Frickenhaus, Francisco Pan-Montojo, Erik Storkebaum, Ina Poser, Axel Freischmidt, Jochen H. Weishaupt, Karlheinz Holzmann, Dirk Troost, Albert C. Ludolph, Tobias M. Boeckers, Stefan Liebau, Susanne Petri, Nils Cordes, Anthony A. Hyman, Florian Wegner, Stephan W. Grill, Joachim Weis, Alexander Storch, Andreas Hermann. Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation. Nature Communications. 2018 Nov 30; 9 doi: 10.1038/s41467-017-02299-1
Arun Pal, Hannes Glaß, Marcel Naumann, Nicole Kreiter, Julia Japtok, Ronny Sczech, Andreas Hermann. High content organelle trafficking enables disease state profiling as powerful tool for disease modelling. Scientific data. 2017 Dec 31; 5 doi: 10.1038/sdata.2018.241
Linse K, Rüger W, Joos M, Schmitz-Peiffer H, Storch A, Hermann A. Eyetracking-based assessment suggests preserved wellbeing in locked-in patients. Ann Neurol. 2017 Jan 01; 81:310-315. doi: 10.1002/ana.24871
Xenia Lojewski, John F. Staropoli, Sunita Biswas-legrand, Alexandra M. Simas, Larissa Haliw, Martin K. Selig, Scott H. Coppel, Kendrick A. Goss, Anton Petcherski, Uma Chandrachud, Steven D. Sheridan, Diane Lucente, Katherine B. Sims, James F. Gusella, Dolan Sondhi, Ronald G. Crystal, Peter Reinhardt, Jared Sterneckert, Hans Schöler, Stephen J. Haggarty, Alexander Storch, Andreas Hermann, Susan L. Cotman. Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway. Human Molecular Genetics. 2014 Mar 31; 23:2005-2022. doi: 10.1093/hmg/ddt596
Hermann A, Gastl R, Liebau S, Popa MO, Fiedler J, Boehm BO, et al. Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells. J Cell Sci. 2004 Sep 01; 117:4411-4422. doi: 10.1242/jcs.01307

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