Neuronale Zellbiologie
Prof. Dr. Thomas Misgeld
Leiter Kooperations-Einheit
Feodor-Lynen-Str. 17
81377 München

thomas.misgeld@dzne.de
 +49 89 4140-3512

Publikationen

Die vollständige Publikationsübersicht findet man hier.

Fecher C, Trovò L, Müller SA, Snaidero N, Wettmarshausen J, Heink S, Ortiz O, Wagner I, Kühn R, Hartmann J, Karl RM, Konnerth A, Korn T, Wurst W, Merkler D, Lichtenthaler SF, Perocchi F, Misgeld T. Cell type-specific profiling of brain mitochondria reveals functional and molecular diversity. Nat Neurosci. 2019 Sep 09;
Witte ME, Schumacher A-M, Mahler CF, Bewersdorf JP, Lehmitz J, Scheiter A, Sánchez P, Williams PR, Griesbeck O, Naumann R, Misgeld T*, Kerschensteiner M (*equal senior author). Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis. Neuron. 2019 Feb 19; 101:615-624.e5. doi: 10.1016/j.neuron.2018.12.023
Misgeld T, Schwarz T. Mitostasis in neurons: Maintaining mitochondria in an extended cellular architecture. Neuron. 2017 Nov 01; 69:651-666. doi: 10.1016/j.neuron.2017.09.055.
Kerschensteiner M, Schwab ME, Lichtman JW, Misgeld T. In vivo imaging of axonal degeneration and regeneration in the injured spinal cord. Nat Med. 2005 May 01; 11:572-7. doi: 10.1038/nm1229
Bishop D, Nikić I, Brinkoetter M, Knecht S, Potz S, Kerschensteiner M, Misgeld T. Near-infrared branding efficiently correlates light and electron microscopy. Nat Methods. 2011 Jun 05; 8:568-70. doi: 10.1038/nmeth.1622
Misgeld T, Kerschensteiner M, Bareyre FM, Burgess RW, Lichtman JW. Imaging axonal transport of mitochondria in vivo. Nat Methods. 2007 Jul 01; 4:559-61. doi: 10.1038/nmeth1055
Plucińska G, Paquet D, Hruscha A, Godinho L, Haass C, Schmid B, Misgeld T.. In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system. Journal of Neuroscience. 2012 Nov 13; 32:16203-16212. doi: 10.1523/JNEUROSCI.1327-12.2012
Kleele T, Marinković P, Williams PR, Stern S, Weigand EE, Engerer P, Naumann R, Hartmann J, Karl RM, Bradke F, Bishop D, Herms J, Konnerth A, Kerschensteiner M, Godinho L, Misgeld T. An assay to image neuronal microtubule dynamics in mice. Nat Commun. 2013 Sep 12; 5:4827. doi: 10.1038/ncomms5827
Breckwoldt MO, Pfister FM, Bradley PM, Marinković P, Williams PR, Brill MS, Plomer B, Schmalz A, St Clair DK, Naumann R, Griesbeck O, Schwarzländer M, Godinho L, Bareyre FM, Dick TP, Kerschensteiner M, Misgeld T. Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo. Nat Med. 2014 Apr 27; 20:555-560. doi: 10.1038/nm.3520
Marinkovic P, Reuter MS, Brill MS, Godinho L, Kerschensteiner M, Misgeld T. Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2012 Mar 13; 109:4296-4301. doi: 10.1073/pnas.1200658109
Nikić I, Merkler D, Sorbara C, Brinkoetter M, Kreutzfeldt M, Bareyre FM, Brück W, Bishop D, Misgeld T*, Kerschensteiner M (*equal senior author). A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med. 2011 Apr 01; 17:495-9. doi: 10.1038/nm.2324
Sorbara CD, Wagner NE, Ladwig A, Nikić I, Merkler D, Kleele T, Marinković P, Naumann R, Godinho L, Bareyre FM, Bishop D, Misgeld T*, Kerschensteiner M (*equal senior author). Pervasive axonal transport deficits in multiple sclerosis models. Neuron. 2013 Dec 31; 84:1183-1190. doi: 10.1016/j.neuron.2014.11.006
Romanelli E, Merkler D, Mezydlo A, Weil MT, Weber M.S, Nikić I, Potz S, Meinl E, Matznick F E.H, Kreutzfeldt M, Ghanem A, Conzelmann KK, Metz I, Brück W, Routh M, Simons M, Bishop D, Misgeld T*, Kerschensteiner M (*equal senior author). Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model. Nat Commun. 2016 Nov 15; 7 doi: 10.1038/ncomms13275
Williams PR, Marincu BN, Sorbara CD, Mahler CF, Schumacher AM, Griesbeck O, Kerschensteiner M, Misgeld T. A recoverable state of axon injury persists for hours after spinal cord contusion in vivo. Nat Commun. 2013 Dec 16; 5 doi: 10.1038/ncomms6683
Brill MS, Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T. Branch-specific microtubule destabilization mediates axon branch loss during neuromuscular synapse elimination. Neuron. 2016 Nov 23; 92:845-856. doi: 10.1016/j.neuron.2016.09.049

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