Neuroprotektive Mechanismen
Prof. Dr. Donato Di Monte
Gruppenleiter
Venusberg-Campus 1, Gebäude 99
(ehemals Sigmund-Freud-Str. 27)
53127 Bonn

donato.dimonte@dzne.de
 +49 228 43302-650

Publikationen

Die vollständige Publikationsliste findet man hier.

Ruth E. Musgrove, Michael Helwig, Eun-Jin Bae, Helia Aboutalebi, Seung-Jae Lee, Ayse Ulusoy, Donato A. Di Monte. Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer. Journal of Clinical Investigation. 2019 Jun 13; 130 doi: 10.1172/JCI127330
Eun-Jin Bae, Dong-Kyu Kim, Changyoun Kim, Michael Mante, Anthony Adame, Edward Rockenstein, Ayse Ulusoy, Michael Klinkenberg, Ga Ram Jeong, Jae Ryul Bae, Cheolsoon Lee, He-Jin Lee, Byung-Dae Lee, Donato A. Di Monte, Eliezer Masliah, Seung-Jae Lee. LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation. Nature Communications. 2018 Nov 30; 9 doi: 10.1038/s41467-018-05958-z
Raffaella Rusconi, Ayse Ulusoy, Helia Aboutalebi, Donato A. Di Monte. Long-lasting pathological consequences of overexpression-induced α-synuclein spreading in the rat brain. Aging Cell. 2018 Mar 31; 17 doi: 10.1111/acel.12727
Ayse Ulusoy, Robert J. Phillips, Michael Helwig, Michael Klinkenberg, Terry L. Powley, Donato A. Di Monte. Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections. Acta Neuropathologica. 2017 Feb 28; 133:381-393. doi: 10.1007/s00401-016-1661-y
Anna Migdalska-Richards, Michal Wegrzynowicz, Raffaella Rusconi, Giulio Deangeli, Donato A. Di Monte, Maria G. Spillantini, Anthony H. V. Schapira. The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice. Brain. 2016 Dec 31; 140:2706-2721. doi: 10.1093/brain/awx221
Michael Helwig, Michael Klinkenberg, Raffaella Rusconi, Ruth E. Musgrove, Nour K. Majbour, Omar M. A. El-Agnaf, Ayse Ulusoy, Donato A. Di Monte. Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice. Brain. 2016 Feb 29; 139:856-870. doi: 10.1093/brain/awv376
Anna Kabanova, Milan Pabst, Markus Lorkowski, Oliver Braganza, Anne Boehlen, Negar Nikbakht, Leonie Pothmann, Ankita R. Vaswani, Ruth Musgrove, Donato A. Di Monte, Magdalena Sauvage, Heinz Beck, Sandra Blaess. Function and developmental origin of a mesocortical inhibitory circuit. Nature Neuroscience. 2014 Dec 31; 18:872-882. doi: 10.1038/nn.4020
Ulusoy A, Musgrove RE, Rusconi R, Klinkenberg M, Helwig M, Schneider A, Di Monte DA. Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury. Acta Neuropathol Commun. 2015 Mar 24; 3:13. doi: 10.1186/s40478-015-0198-y
Bodea LG, Wang Y, Linnartz-Gerlach B, Kopatz J, Sinkkonen L, Musgrove R, Kaoma T, Muller A, Vallar L, Di Monte DA, Balling R, Neumann H. Neurodegeneration by activation of the microglial complement-phagosome pathway. J Neurosci. 2014 Jun 18; 34:8546-56. doi: 10.1523/JNEUROSCI.5002-13.2014
Pérez-Revuelta, Hettich, Ciociaro, Rotermund, Kahle, Krauss, Di Monte. Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation. Cell Death and Disease. 2013 Dec 31; 5 doi: 10.1038/cddis.2014.175
Ayse Ulusoy, Raffaella Rusconi, Blanca I. Pérez-Revuelta, Ruth E. Musgrove, Michael Helwig, Bettina Winzen-Reichert, Donato A. Di Monte. Caudo-rostral brain spreading of α-synuclein through vagal connections. EMBO Molecular Medicine. 2013 Jun 30; 5:1051-1059. doi: 10.1002/emmm.201302475
McCormack, Mak, Di Monte. Increased a-synuclein phosphorylation and nitration in the aging primate substantia nigra. Cell Death and Disease. 2012 May 23; 3 doi: 10.1038/cddis.2012.50
Mak SK, McCormack AL, Manning-Bog AB, Cuervo AM, Di Monte DA. Lysosomal degradation of alpha-synuclein in vivo. J Biol Chem. 2010 Apr 30; 285:13621-9. doi: 10.1074/jbc.M109.074617

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