Wolfgang Wurst
Genome Engineering
Prof. Dr. Wolfgang Wurst
Gruppenleiter (kommissarisch)
Die Core Facility „Transgene Einheit“ und „Verhaltensanalyse von Mausmodellen“ sind dem Lehrstuhl von Prof. Wurst (HMGU; TU) assoziiert
Ingolstädter Landstr. 1
85764 Oberschleißheim-Neuherberg

wolfgang.wurst@dzne.de
 +49 89 3187-4111

Publikationen

Die vollständige Publikationsliste findet man hier.

Fecher C, Trovò L, Müller SA, Snaidero N, Wettmarshausen J, Heink S, Ortiz O, Wagner I, Kühn R, Hartmann J, Karl RM, Konnerth A, Korn T, Wurst W, Merkler D, Lichtenthaler SF, Perocchi F, Misgeld T. Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity. Nat Neurosci. 2019 Oct 01; 22:1731-1742. doi: 10.1038/s41593-019-0479-z
Funk N, Munz M, Ott T, Brockmann K, Wenninger-Weinzierl A, Kühn R, Vogt-Weisenhorn D, Giesert F, Wurst W, Gasser T, Biskup S. The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4. Sci Rep. 2019 Mar 14; 9:4515. doi: 10.1038/s41598-019-40808-y
Schäffner I, Minakaki G, Khan MA, Balta EA, Schlötzer-Schrehardt U, Schwarz TJ, Beckervordersandforth R, Winner B, Webb AE, DePinho RA, Paik J, Wurst W, Klucken J, Lie DC. FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis. Neuron. 2019 Sep 19; 99:1188-1203. doi: 10.1016/j.neuron.2018.08.017
Xianyuan Xiang, Thomas M. Piers, Benedikt Wefers, Kaichuan Zhu, Anna Mallach, Bettina Brunner, Gernot Kleinberger, Wilbur Song, Marco Colonna, Jochen Herms, Wolfgang Wurst, Jennifer M. Pocock, Christian Haass. The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans. Molecular Neurodegeneration. 2018 Sep 05; 13 doi: 10.1186/s13024-018-0280-6
Dedic N, Kühne C, Jakovcevski M, Hartmann J, Genewsky AJ, Gomes KS, Anderzhanova E, Pöhlmann ML, Chang S, Kolarz A, Vogl AM, Dine J, Metzger MW, Schmid B, Almada RC, Ressler KJ, Wotjak CT, Grinevich V, Chen A, Schmidt MV, Wurst W, Refojo D, Deussing JM. Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nat Neurosci. 2018 Jun 01; 21:803-807. doi: 10.1038/s41593-018-0151-z
Martin H. Schludi, Lore Becker, Lillian Garrett, Tania F. Gendron, Qihui Zhou, Franziska Schreiber, Bastian Popper, Leda Dimou, Tim M. Strom, Juliane Winkelmann, Anne von Thaden, Kristin Rentzsch, Stephanie May, Meike Michaelsen, Benjamin M. Schwenk, Jing Tan, Benedikt Schoser, Marianne Dieterich, Leonard Petrucelli, Sabine M. Hölter, Wolfgang Wurst, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Thomas Klopstock, Thomas Arzberger, Dieter Edbauer. Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss. Acta Neuropathologica. 2017 Jul 31; 134:241-254. doi: 10.1007/s00401-017-1711-0
Meehan TF, Conte N, West DB, Jacobsen JO, Mason J, Warren J, Chen CK, Tudose I, Relac M, Matthews P, Karp N, Santos L, Fiegel T, Ring N, Westerberg H, Greenaway S, Sneddon D, Morgan H, Codner GF, Stewart ME, Brown J, Horner N; International Mouse Phenotyping Consortium, Haendel M, Washington N, Mungall CJ, Reynolds CL, Gallegos J, Gailus-Durner V, Sorg T, Pavlovic G, Bower LR, Moore M, Morse I, Gao X, Tocchini-Valentini GP, Obata Y, Cho SY, Seong JK, Seavitt J, Beaudet AL, Dickinson ME, Herault Y, Wurst W, de Angelis MH, Lloyd KCK, Flenniken AM, Nutter LMJ, Newbigging S, McKerlie C, Justice MJ, Murray SA, Svenson KL, Braun RE, White JK, Bradley A, Flicek P, Wells S, Skarnes WC, Adams DJ, Parkinson H, Mallon AM, Brown SDM, Smedley D. Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nat Genet. 2017 Aug 01; 49:1231-1238. doi: 10.1038/ng.3901
Gernot Kleinberger, Matthias Brendel, Eva Mracsko, Benedikt Wefers, Linda Groeneweg, Xianyuan Xiang, Carola Focke, Maximilian Deußing, Marc Suárez-Calvet, Fargol Mazaheri, Samira Parhizkar, Nadine Pettkus, Wolfgang Wurst, Regina Feederle, Peter Bartenstein, Thomas Mueggler, Thomas Arzberger, Irene Knuesel, Axel Rominger, Christian Haass. The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. EMBO Journal. 2017 Jul 02; 36:1837-1853. doi: 10.15252/embj.201796516
Benedikt Wefers, Sanum Bashir, Jana Rossius, Wolfgang Wurst, Ralf Kühn. Gene editing in mouse zygotes using the CRISPR/Cas9 system. Methods. 2017 May 14; 121-122:55-67. doi: 10.1016/j.ymeth.2017.02.008
Joel A. Schick, Claudia Seisenberger, Joachim Beig, Antje Bürger, Vivek Iyer, Viola Maier, Sajith Perera, Barry Rosen, William C. Skarnes, Wolfgang Wurst. CRISPR-Cas9 enables conditional mutagenesis of challenging loci. Scientific Reports. 2016 Aug 31; 6 doi: 10.1038/srep32326
Chu VT, Weber T, Wefers B, Wurst W, Sander S, Rajewsky K, Kühn R. Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. Nat Biotechnol. 2015 May 01; 33:543-8. doi: 10.1038/nbt.3198
Sabine M. Hölter, Jan Einicke, Bettina Sperling, Annemarie Zimprich, Lillian Garrett, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabé de Angelis, Wolfgang Wurst. Tests for Anxiety-Related Behavior in Mice. Current protocols in mouse biology. 2014 Dec 31; 5:291-309. doi: 10.1002/9780470942390.mo150010
Benedikt Wefers, Sudeepta K. Panda, Oskar Ortiz, Christina Brandl, Svenja Hensler, Jens Hansen, Wolfgang Wurst, Ralf Kühn. Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA. Nature Protocols. 2012 Dec 31; 8:2355-2379. doi: 10.1038/nprot.2013.142
Wefers B, Meyer M, Ortiz O, Hrabé de Angelis M, Hansen J, Wurst W, Kühn R. Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides. Proc Natl Acad Sci U S A. 2013 Mar 05; 110:3782-7. doi: 10.1073/pnas.1218721110
International Mouse Knockout Consortium, Collins FS, Rossant J, Wurst W. A mouse for all reasons. Cell. 2007 Jan 12; 128:9-13. doi: 10.1016/j.cell.2006.12.018

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