We decipher how neurons grow and regenerate their axons. From basic cellular mechanisms to in vivo growth and regeneration via pharmacological interventions and rehabilitation, we strive to understand these processes to aid the fight against neuro traumatic injuries and neurodegenerative disease.

After an impressive research career in our group and two papers (one published, one submitted), Max , formerly known as Master Schelski, decided it was time to graduate and submit his PhD thesis. Following a fantastic presentation, it was Frank's honour to crown the newly minted Doctor Schelski with the customary PhD hat. Very well deserved Max and best of luck in your coming endeavours on theoretical modelling of dendrites and synaptic plasticity with the Tchumatchenko group!

What else is going on?

An intrinsic cytoskeletal oscillator establishes neuronal polarity.
Lin TC, et al.

Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain.
Vinopal S, Dupraz S, et al.

Neuronal maturation and axon regeneration: unfixing circuitry to enable repair.
Hilton BJ, et al.

Microtubule retrograde flow retains neuronal polarization in a fluctuating state.
Schelski M, Bradke F.

An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury.
Hilton BJ, et al.

RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury.
Stern S, Hilton BJ, et al.

Axon Growth of CNS Neurons in Three Dimensions Is Amoeboid and Independent of Adhesions.
Santos TE, Schaffran B, et al.

ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS.
Tedeschi A, et al.

RhoA Controls Axon Extension Independent of Specification in the Developing Brain.
Dupraz S, et al.

High-resolution 3D imaging and analysis of axon regeneration in unsectioned spinal cord with or without tissue clearing.
Hilton BJ, et al.