We decipher how neurons grow and regenerate their axons. From basic cellular mechanisms to in vivo growth and regeneration via pharmacological interventions and rehabilitation, we strive to understand these processes to aid the fight against neuro traumatic injuries and neurodegenerative disease.

On July 1st, Kai Fährmann successfully defended his PhD. He delivered an exciting talk summarising his work on GPC1 as a promising candidate for axon regeneration. Following the defense, Kai received the traditional Doktorhut to commemorate this milestone. Huge congratulations, Dr. Fährmann!

What else is going on?

Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain.
Vinopal S, Dupraz S, et al.

Neuronal maturation and axon regeneration: unfixing circuitry to enable repair.
Hilton BJ, et al.

Microtubule retrograde flow retains neuronal polarization in a fluctuating state.
Schelski M, Bradke F.

An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury.
Hilton BJ, et al.

RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury.
Stern S, Hilton BJ, et al.

Axon Growth of CNS Neurons in Three Dimensions Is Amoeboid and Independent of Adhesions.
Santos TE, Schaffran B, et al.

ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS.
Tedeschi A, et al.

RhoA Controls Axon Extension Independent of Specification in the Developing Brain.
Dupraz S, et al.

High-resolution 3D imaging and analysis of axon regeneration in unsectioned spinal cord with or without tissue clearing.
Hilton BJ, et al.