Laboratory Automation Technologies (LAT)

• General Terms of Use (English)
• General Terms of Use (German)
• For pricing information, please contact philip.denner(at)dzne.de

• Automated Screening Platform
• CellVoyager CV6000 (Yokogawa Inc.)
• Operetta (PerkinElmer)
• ParadigmReader (MolecularDevices)
• BioMek NXP and Span-8 (Beckman Coulter)
• Echo 550 (Labcyte)

STT1000-Kiwi (Lyconic)
Fully automated plate and tube storage system with remote sample access, integrated database and Tube Picker system for the consolidation of tube racks or tubes cherry picking. The instrument has temperature range control between +20°C and -20°C and possibility to store 520 plates or 49920 Tubes.

Automated Incubator Cytomat 6001 (Thermo Scientific)
Two automated incubators with a plate shuttle system are integrated into our screening platform. The first incubator has a temperature range between 20°C (RT) and 50°C. Second incubator has the additional cooling cryostat enabling stable control of temperature range between 4°C and 70°C and an additional function for O2 control. Both incubators have capacity of up to 189 standard microplates and stable CO2 and humidity control. This set-up enables us to perform continues live cell assays under precisely controlled environmental conditions and scheduled automated imaging.

Cytomat Hotel (Thermo Scientific)
Automated ambient storage device with a plate shuttle system that offers storage for up to 189 standard microplates, tip boxes, tube racks etc.

Capit-All IS (Thermo Scientific)
Automated Capper/Decapper that can remove and replace screw caps at once on 96- and 24-format matrix tubes in only 10 seconds/rack.

VisionMate High Speed 2D Barcode Reader (Thermo Scientific)
2D barcode reader controlled through the automation system that can read both single tube and full 2D rack format.

XPeel Plate De-Sealer (Brooks)
For automated seal removal.

Print and Apply, SAGIAN™ Microplate (Beckman Coulter)
For microplate labeling and tracking, adopted for four-sided label application.

PlateLoc Thermal Microplate Sealer (Agilent Technologies)
High speed, fully automated thermal sealer.

Microplate Centrifuge (Agilent Technologies)
Automated centrifuge for microplates.

Microplate Delidder (Thermo Scientific)
For removal, storage and replacement of lids on microplates. Six delidder instruments are fully integrated in our automated screening platform.

Multidrop Combi Reagent Dispenser (Thermo Scientific)
Allows precise dispensing over a 0.5µl to 2500µl range into 6 to 1536 wells microplates with minimal dead volume and back-flushing function. Multidrop Combi utilizes autoclavable 8-channel dispensing cassettes. Four instruments are fully integrated in our automated screening platform.

• Compound collection of pharmacologically active small molecules with known primary targets (ca. 2,4K compounds).
• Synthetic small molecule libraries from Chembridge collections (42K compounds).
• Synthetic small molecule libraries from ChemDiv. collections (37K compounds)

• miRNA collection from Ambion
  • human pre-miR miRNA library
  • human anti-miR miRNA library

• miRNA collection from Ambion
  • human pre-miR miRNA library
  • human anti-miR miRNA library

LAT provide a wide range of compound screenings and high-throughput assays:

• "Small molecule" screening from the LAT library collection.
• "Loss of function" siRNA screening.
• "Loss or gain of function" miRNA screening.
• Dose response assays of "cherry-picked" compounds, siRNAs or miRNAs.

• Multi parametric High-Content Screening (HCS)
• Fully automated image-based live cell assays
• Homogenous cell-based assays: Fluorescence, Luminescence, Time Resolved Fluorescence (TRF), Alpha Screen, Fluorescence Polarization (FP)
• Isolated molecular target assays.
• Cell/Organism image-based assays.
• Reporter gene assays.
• Phenotypic assays.