DESCRIBE-COGNITION
DZNE - Clinical Registry Study on cognitive function in Alzheimer’s disease
Background and aims
Alzheimer's disease is the most common cause of dementia. Although research has made progress in recent years, there are still many unanswered questions, particularly regarding the progression of the disease and early changes. Changes in the blood vessels can also lead to a decline in mental performance.
The German Center for Neurodegenerative Diseases (DZNE) therefore plans to examine participants regularly over an extended period as part of the DESCRIBE-COGNITION study. The study is open to people experiencing changes in their cognitive abilities, as well as those living with early-stage dementia. The goal is to gain a better understanding of how the disease progresses and the factors that may contribute.
Overview
DESCRIBE-COGNITION is a study that observes the progression of the disease over an extended period of time. Participants are examined during several in-person visits.
Course of the study
In the forefront of the study, the investigator will inform you about the examinations and study procedures. Further questions can be discussed in detail during the consultation. All participants in the DESCRIBE-COGNITION study will receive a standardized assessment.
If you consent to participate in the study, the following will take place:
- an interview about your medical history, including the presence of other neurodegenerative diseases in your family
- a neurological examination and information about your medication
- an examination of your memory, concentration and mood
- a blood sampling to determine biochemical and genetic characteristics
- a scientific MRI-Scan
- a lumbar puncture every 2 years
Study participation
If you would like to take part in this study, please contact a study team in your area. You will find the contact details in the list of participating sites.
Principal Investigators: Prof. Frank Jessen and Prof. Dr. Gabor Petzold
Start of the study: 2025
Status: multicentric, running, recruitment active