Clinical Dementia Research
Prof. Dr. Stefan Teipel
Head of clinical research Rostock/Greifswald,
Group Leader and Deputy Site Speaker
Gehlsheimer Str. 20
18147 Rostock

stefan.teipel@dzne.de
 +49 381 494-9470

Areas of investigation/research focus

Our focus is on clinical dementia research. We aim to improve early diagnosis and treatment of dementia with special emphasis on Alzheimer's disease (AD), to evaluate new technologies in real word environments and to involve patients and caregivers in the innovation process.

The first research line aims to transfer diagnostic and intervention concepts from the phase of methodological development through experimental settings into routine care. AD biomarkers are currently being used in specialized care to increase prediction accuracy for in prodromal stages (prognostic biomarkers), and to differentiate AD from non-AD dementias (diagnostic biomarkers). In the near future, we will need case finding for secondary preventive treatments (theranostic biomarkers). Assessing the effectivity and efficiency of such markers requires their evaluation not only in highly selected samples but also in patients from routine care.The second research line aims to develop and implement information and communication technologies, such as wearable sensors and dense (environmental) sensing, as patient-powered real world endpoints for clinical studies to monitor neurodegenerative disease progression and intervention effects. This research line adds a vertical dimension to the horizontal dimension for extending clinical studies to routine care and provides access to broader patient populations for a novel type of phase 4 and 5 (disease control) clinical studies.

 more Infos

Results of diagnostic and intervention trials in specialized care cannot be easily transferred into primary care due to the potential bias through systematic selection. In an international phase 3 study, we developed and evaluated a harmonized protocol for hippocampus measurement from MRI scans and extended this harmonized protocol towards automated volumetry. We established imaging biomarkers in phase 3 studies using multicenter data (EDSD, PsyMRI) and conducted a phase 4 diagnostic trial to determine the diagnostic accuracy of MRI based volumetry in primary care. We also explore novel molecular imaging modalities, including amyloid- and tau-sensitive PET.

A technical assistance system can provide suitable support for mobility outside the home; we examined the technical feasibility of a subsidiary assistance system for mobility (SiNDeM), and an expert system to support caregivers of people with dementia (InsideDem). Currently, we are developing a sensor-based personal activity management assistant (SAMi). A key approach is participatory innovation, where patient and caregivers are involved already in the design process of a new technology development.

Complementing the dementia care management of the DelpHi-MV trial we study feasibility, effectiveness, implementation and adoption of patient and caregiver-centered interventions in cooperation with the German Alzheimer’s Association, section Mecklenburg Western-Pomerania (AA-MV).

Key Publications

Giovanni B Frisoni, Marina Boccardi, Frederik Barkhof, Kaj Blennow, Stefano Cappa, Konstantinos Chiotis, Jean-Francois Démonet, Valentina Garibotto, Panteleimon Giannakopoulos, Anton Gietl, Oskar Hansson, Karl Herholz, Clifford R Jack, Flavio Nobili, Agneta Nordberg, Heather M Snyder, Mara Ten Kate, Andrea Varrone, Emiliano Albanese, Stefanie Becker, Patrick Bossuyt, Maria C Carrillo, Chiara Cerami, Bruno Dubois, Valentina Gallo, Ezio Giacobini, Gabriel Gold, Samia Hurst, Anders Lönneborg, Karl-Olof Lovblad, Niklas Mattsson, José-Luis Molinuevo, Andreas U Monsch, Urs Mosimann, Alessandro Padovani, Agnese Picco, Corinna Porteri, Osman Ratib, Laure Saint-Aubert, Charles Scerri, Philip Scheltens, Jonathan M Schott, Ida Sonni, Stefan Teipel, Paolo Vineis, Pieter Jelle Visser, Yutaka Yasui, Bengt Winblad. Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers. The Lancet Neurology. 2017 Jul 31; 16:661-676. doi: 10.1016/S1474-4422(17)30159-X
Jochen René Thyrian, Johannes Hertel, Diana Wucherer, Tilly Eichler, Bernhard Michalowsky, Adina Dreier-Wolfgramm, Ina Zwingmann, Ingo Kilimann, Stefan Teipel, Wolfgang Hoffmann. Effectiveness and safety of dementia care management in primary care: A randomized clinical trial. JAMA Psychiatry. 2017 Sep 30; 74:996-1004. doi: 10.1001/jamapsychiatry.2017.2124
Stefan Teipel, Claudio Babiloni, Jesse Hoey, Jeffrey Kaye, Thomas Kirste, Oliver K. Burmeister. Information and communication technology solutions for outdoor navigation in dementia. Alzheimer's and Dementia. 2016 May 31; 12:695-707. doi: 10.1016/j.jalz.2015.11.003
Michel J. Grothe, Helmut Heinsen, Edson Amaro, Lea T. Grinberg, Stefan J. Teipel. Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in Mild Cognitive Impairment. Cerebral Cortex. 2015 Dec 31; 26:2411-2426. doi: 10.1093/cercor/bhv062
Stefan Teipel, Alexander Drzezga, Michel J. Grothe, Henryk Barthel, Gaël Chételat, Norbert Schuff, Pawel Skudlarski, Enrica Cavedo, Giovanni B. Frisoni, Wolfgang Hoffmann, Jochen René Thyrian, Chris Fox, Satoshi Minoshima, Osama Sabri, Andreas Fellgiebel. Multimodal imaging in Alzheimer's disease: Validity and usefulness for early detection. The Lancet Neurology. 2015 Sep 30; 14:1037-1053. doi: 10.1016/S1474-4422(15)00093-9

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