Non-motor symptoms in Parkinson's disease
Prof. Dr. Alexander Storch
Group Leader
Gehlsheimer Str. 20
18147 Rostock

alexander.storch@dzne.de
 +49 381 494-9511

Areas of investigation/research focus

The major field of interest of the Storch group is the characterization and treatment of non-motor symptoms in movement disorders such as Parkinson’s disease and other motor system degenerative diseases such as Amyotrophic lateral sclerosis (ALS). In focus are cognitive dysfunctions, which we study using learning and memory tests with functional and innovative morphological imaging methods.

We are interested in the development of regenerative therapies for Parkinson’s disease with focus on stem-cell based therapies. We employ fetal tissue-specific neural stem cells, adult neural stem cells and stem cells from bone marrow to determine their behavior and potential. We explore basic stem cell biology by examining stem cell proliferation and differentiation into functional dompaminergic neurons. In particular, mechanisms that govern proliferation and fate specification of predopaminergic precursor cells are investigated. Studying adult neurogenesis in healthy and diseased conditions should identify possible targets for endogenous regeneration. In vivo studies should improve targeted dopaminergic reinnervation of the diseased nigrostriatal pathway using biopolymer assisted transplantation for stem cells.

Key Publications

Matthias Löhle, Julia Mende, Martin Wolz, Bettina Beuthien-Baumann, Liane Oehme, Jörg Van Den Hoff, Jörg Kotzerke, Heinz Reichmann, Alexander Storch. Putaminal dopamine turnover in de novo Parkinson disease predicts later motor complications. Neurology. 2016 Jan 18; 86:231-240. doi: 10.1212/WNL.0000000000002286
Christiana Franke, Alexander Storch. Nonmotor Fluctuations in Parkinson's Disease. Neurology. 2016 Dec 31; 134:947-971. doi: 10.1016/bs.irn.2017.05.021
Hermann A, Suess C, Fauser M, Kanzler S, Witt M, …, Storch A. Rostro-caudal gradual loss of cellular diversity within the periventricular regions of the ventricular system. Stem Cells. 2009 Jan 01; 27:928-41. doi: 10.1002/stem.21
Weber YG, Storch A, Wuttke T, Brockmann K, Kempfle J, Maljevic S, et al. GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak. J Clin Invest. 2008 Jan 01; 118:2157-68. doi: 10.1172/JCI34438
Storch A, Jost W, Vieregge P, Spiegel J, Greulich W, Durner J, et al. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q10 in Parkinson’s disease. Arch Neurol. 2007 Jan 01; 64:938-44. doi: 10.1001/archneur.64.7.nct60005

Info-Hotline

Thursdays 1:30-4:30 pm

Patients +49 800-7799001

(free of charge)

Professionals +49 180-779900

(9 Cent/Min. German landline, mobile and out of Germany possibly more expensive)

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