Interdisciplinary Dementia Research
Prof. Dr. Matthias Endres
Head of Clinical Research Berlin
Campus Mitte, c/o Universitätsmedizin Berlin
Klinik und Poliklinik für Neurologie
Charitéplatz 1
10117 Berlin

matthias.endres@dzne.de
 +49 30 450-560101

Areas of investigation/research focus

Albeit the sudden onset of stroke, post-stroke inflammatory, regenerative and repair processes are active over weeks and months. To date, little is known about long-term effects of these processes on neurodegeneration and cognitive decline. In my group, we seek to gain more insights into mechanisms and potential preventive strategies using clinical and pre-clinical studies. We have a special focus on:

  • Preventive vascular mechanisms (endothelial function, physical activity, pharmacology)
  • Mechanisms of cell death (cell cycle activation, DNA damage and repair, apoptosis)
  • Regeneration and functional outcome (cellular plasticity, neurogenesis)
  • Clinical studies on post-stroke dementia, stroke prophylaxis, telemedicine
 more Infos

At the DZNE study side Berlin I am coordinating the DZNE - Mechanisms of Dementia After Stroke (DEMDAS) Study and the Association of High Troponin levels and Cognitive Impairment: Results from the Berlin Aging Study II (BASE-II). More information on these studies and the substudies coordinated in Berlin can be found below.

For more information on the Endres group please visit

expneuro.charite.de/en/research&research_teams/interdisciplinary_stroke_research/

At the DZNE study side Berlin I coordinate the following projects:

Project 1:

The DZNE - Mechanisms of Dementia After Stroke (DEMDAS) Study

This study is coordinated by Prof. Dichgans and Berlin is one of the active recruiting sites of this intersite cohort study. I contribute as Co-PI and together with colleagues from Berlin we will coordinate several substudies. The scientific questions of these substudies include: Role of lipoprotein-associated phospholipase A2 and lipoprotein (A) and the risk of dementia and cognitive decline following stroke; role of pathogeneic autoantibodies in dementia after stroke; role of high-sensitivity cardiac troponin for prediction of stroke-stroke dementia and cognitive decline (see Project 2).

Project 2:

Association of High Troponin levels and Cognitive Impairment: Results from the Berlin Aging Study II (BASE-II).

Here, we test the hypothesis whether higher levels of cardiac troponin T levels are independently associated with cognitive impairment and are a risk factor for future dementia (Nolte and Endres, 2014). The Berlin Aging Study II (BASE-II) is a community-dwelling study of the greater metropolitan area of Berlin comprising 2,200 well-characterized residents with 500 individuals aged younger than 40 years and the others older than 60 years. We hypothesize that subclinical troponin levels are associated with cognitive impairment and cognitive decline over time.

Key Publications

Kronenberg G, Balkaya M, Prinz V, Gertz K, Ji S, […], Endres M. Exofocal dopaminergic degeneration as antidepressant target in mouse model of poststroke depression. Biol Psychiatry. 2012 Jan 01; 72:273-81. doi: 10.1016/j.biopsych.2012.02.026
Gertz K, Kronenberg G, Kalin RE, Baldinger T, Werner C, […], Endres M. Essential role of interleukin-6 in post-stroke angiogenesis. Brain. 2012 Jan 01; 135:1964-80. doi: 10.1093/brain/aws075
Endres M, Biniszkiewicz D, Sobol RW, Harms C, Ahmadi M, Lipski A, et al. Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. J Clin Invest. 2004 Jan 01; 113:1711-21. doi: 10.1172/JCI20926
Endres M, Fink K, Zhu J, Stagliano NE, Bondada V, Geddes JW, et al. Neuroprotective effects of gelsolin during murine stroke. J Clin Invest. 1999 Jan 01; 103:347-54. doi: 10.1172/JCI4953
Endres M, Laufs U, Huang Z, Nakamura T, Huang P, Moskowitz MA, et al. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci USA. 1998 Jan 01; 95:8880-5.

Info-Hotline

Thursdays 1:30-4:30 pm

Patients +49 800-7799001

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Professionals +49 180-779900

(9 Cent/Min. German landline, mobile and out of Germany possibly more expensive)

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