Research at the DZNE

The DZNE investigates the causes of diseases of the brain and the nervous system and develops novel strategies for prevention, treatment, and patient care. Our research focuses on “neurodegeneration”, a pathological, slowly progressing phenomenon characterized by neuronal damage and dysfunctions, which can ultimately lead to cell death. Neurodegeneration may cause dementia, movement disorders and other serious health issues. It manifests in a wide spectrum of diseases including Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS), ataxias and childhood onset neurodegenerative disorders.
We aim to improve quality of life of patients and relatives. Therefore, the DZNE’s scientific strategy comprises various research areas ranging “from bench to bedside”, our scientists cooperating across disciplines to support translation of scientific findings into medical application.
Thus, the DZNE covers the whole spectrum from the investigation of molecular processes in simple organisms and brain cells to clinical studies, population and health care research. Some topics are tackled in laboratory experiments, others in  studies in which healthy subjects and individuals affected by disease participate. For the development of novel therapies and medicines, the DZNE collaborates with other scientific institutions and research-based companies – both in Germany and worldwide.

Progress in the research on neurodegenerative diseases requires latest technology. Therefore, the DZNE operates a state-of-the-art infrastructure in neuroimaging and single-cell genomics (PRECISE). Moreover, the DZNE’s Core Facilities offer a broad range of technologies and services to support the work of our scientists.

Translational Research

To facilitate translation of scientific findings into clinical routines and patient care, the DZNE pursues an interdisciplinary strategy that comprises four interconnected research areas: