Site Magdeburg

In Magdeburg, the DZNE is researching the basis for new therapies against Alzheimer’s and other diseases of the nervous system, directing its attention especially on how to identify biomarkers and cognitive markers.

The focus is on translating experimental findings into clinically relevant biomarkers and—ultimately—into therapies. In order to be able to assess the severity of a disease and offer patient-tailored treatment, the cognitive markers are particularly important. Here, the Magdeburg researchers have concentrated primarily on spatial orientation skills, memory networks, and other memory processes. This is because experimental results can be transferred particularly well to the clinic in this context.

The site is also researching how to develop new therapeutic approaches for medications, mental health, and physical therapy. The goal of these therapies is to preserve, rebuild, or regain the functions of the brain.

Among other things, the focus is on what is known as plasticity, a special characteristic of the brain to change its structure and function and to adapt to new circumstances. The experts in Magdeburg are investigating how this works, from observational studies to intervention studies that analyze whether and how physical training or dancing has a positive effect on the brain.

In all areas of research, the site relies on state-of-the-art research methods, ranging from highly complex simulations that use virtual reality to high-resolution magnetic resonance imaging (MRI).