The overarching goals of the site DZNE Magdeburg are
i) Identification of functional and structural biomarkers along with cognitive signatures for network dysfunction in early stages of neurodegenerative disease pathology across multiple species;
ii) Identification of alterations in neurovascular function and plasticity caused by the interaction of metabolic risk and neurodegenerative disease pathology;
iii) Development of pharmacological, cognitive and physical interventions that allow stabilization, reorganization or regaining cognitive functions.
To achieve these goals, we have established synergistic human and animal research areas on synaptic plasticity and cognitive circuit function that spans from molecular to network mechanisms.
We collaborate with the Department of Neurology (Medical Faculty of the Otto-von-Guericke University) to enable interested older adults and patients access to a large variety of DZNE research studies, ranging from observational studies to intervention studies such as exercise and dancing.
A key aspect of our research is to translate experimental findings into clinically useful biomarkers and therapies. A major focus in that regard is to develop novel cognitive markers for differential diagnosis, staging and outcome assessment that have a clear relationship to the functional architecture of cognition in humans and also relate to animal research. The key topics include spatial navigation, memory pathways in the medial temporal lobe, and anatomically defined component processes of memory, such as visual discrimination, pattern separation, pattern completion, and maintenance. We advance several aspects of the species- overarching research on these processes and thus establish ways to directly link results in animal and human studies.
Therapeutically, the translational projects in Magdeburg focus on plasticity, metabolic dysfunction, neuromodulatory dysfunction, Aß and tau toxicity. We are searching for peripheral factors that can boost brain plasticity and improve memory function as a result of cardiovascular exercise, we are developing treatments targeting the neural extracellular matrix to improve structural and functional plasticity in the hippocampus and multiple cortical areas, we are studying the mechanisms that lead to insulin resistance and how it can be overcome pharmacologically and non-pharmacologically in the presence of amyloid pathology, we study the contributions of vascular dysfunction to neurodegeneration but also determine the scope for vascular plasticity, we are investigating dopaminergic and noradrenergic dysfunction and how they contribute to cognitive dysfunction and interact with amyloid- and tau-pathology, and we are investigating mechanisms through which tau- and amyloid-pathology can lead to impairment of brain function in rodents and humans.
- StructureProf. Dr. Emrah DüzelSite Speakeremrah.firstname.lastname@example.org+49 391 6117-520Prof. Dr. Hans-Jochen HeinzeDeputy Speakerhansemail@example.com+49 391 6713431Dr. Janine SiegfriedCoordinatorjanine.firstname.lastname@example.orgLeipziger Str. 4439120Magdeburg+49 391 67-24531
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