Jan Gründemann. PHOTO Sara Barth
Neural Circuit Computations (from 10/01/2020)
Prof. Dr. Jan Gründemann
Group Leader
Venusberg-Campus 1
Gebäude 99
53127  Bonn

jan.grundemann@dzne.de

Areas of investigation/research focus

Reliable integration of an ever-changing multitude of sensory inputs from the environment is the basis for learning and memory and shapes our behaviours. Our research aims to understand how sensory inputs are represented and computed to elucidate key principals of multisensory integration. To address this question, we combine state of the art circuit neuroscience tools like opto- and pharmacogenetics with single and two-photon imaging techniques to reveal computational frameworks of multisensory integration in deep brain areas and their effects on behaviour and learning in health and disease.

Key Publications

Gründemann* J, Bitterman* Y, Lu T, Krabbe S, Grewe BF, Schnitzer MJ, Lüthi A. Amygdala ensembles encode behavioral states. Science. 2019 Apr 19; 364:eaav8736. doi: 10.1126/science.aav8736
Grewe BF, Gründemann J, Kitch LJ, Lecoq JA, Parker JG, Marshall JD, Larkin MC, Jercog PE, Grenier F, Li JZ, Lüthi A, Schnitzer MJ. Neural ensemble dynamics underlying a long-term associative memory. Nature. 2017 Mar 30; 543:670-675. doi: 10.1038/nature21682
Gründemann J, Clark BA. Calcium-Activated Potassium Channels at Nodes of Ranvier Secure Axonal Spike Propagation. Cell Rep. 2015 Sep 22; 12:1715-22. doi: 10.1016/j.celrep.2015.08.022
Wolff SBE*, Gründemann J*, Tovote P, Krabbe S, Jacobson GA, Müller C, Herry C, Ehrlich I, Friedrich RW, Letzkus JJ, Lüthi A (*co-first authors). Amygdala interneuron subtypes control fear learning through disinhibition. Nature. 2014 Jan 01; 509:453-458. doi: 10.1038/nature13258
Gründemann J, Schlaudraff F, Haeckel O, Liss B. Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease. Nucleic Acids Res. 2008 Jan 01; 36:e38. doi: 10.1093/nar/gkn084.

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