APP: At the source of Alzheimer's disease
In research, Alzheimer's is often described as a cascade - a sequence of many different processes leading to the typical symptoms of the disease. If you…
The number one Alzheimer's risk factor ApoE4
The protein ApoE4 is considered the most important genetic risk factor for Alzheimer's disease.
One of the central questions in Alzheimer's research is…
Amyloid: the trigger of a lethal cascade leading to nerve cell death
In Alzheimer's patients, clumps of amyloid form in the brain long before the first symptoms appear. They play a central role in…
ADAM10: A protective shield against the harmful amyloid
The ADAM10 enzyme can be imagined as a pair of scissors: In the nerve cells of the brain, it attaches itself to a specific protein, which it…
When movement dies
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects a very specific group of neurons: the neurons for voluntary motor function, also known as motor…
Hirn & Heinrich
Episode 26: Demenz durch Schlaganfall und Bluthochdruck
When blood flow in the brain is restricted
Vascular dementia is an umbrella term for diseases in which the function…
More than just tremor
Parkinson's disease is the second most common neurodegenerative disease – right after Alzheimer's disease. According to estimates, there are at least 200,000 people affected in…
Sensory illusions and mental and physical impairments
Lewy body dementia usually occurs after the age of 65. To date, it is not really clear whether Lewy body dementia is a disease in its own…
Progressive loss of cognitive abilities
Dementia is not just a matter of age. Children and adolescents can also be affected by progressive neurodegenerative diseases. More than 250 different…
Gamma secretase: the final step in the formation of amyloid
Gamma secretase works like a microscopic pair of scissors: in the cells, it cuts long protein chains into shorter sections. One of these…
