GenHighfield

Study of the Influence of Apolipoprotein-E Polymorphisms on the Structure and Function of Hippocampus Formation, using EEG and Ultra-High-Field 7T MRI

This study looked at how the apolipoprotein-E gene affects the structure (MRI) and activity (fMRI) as well as on the oscillatory EEG activity of specific hippocampal subregions. To this end, a pattern separation / pattern completion paradigm was applied using a 7T-MRI scanner.

Principle Investigator: Prof. Dr. Nikolai Axmacher
Start of the study: 2014
Status: Study closed, data published

Study Coordination / Project Management

Prof. Dr. Nikolai Axmacher

nikolai.axmacher@rub.de

+49 234 32-22674

Publications

Lee H, Stirnberg R, Wu S, Wang X, Stöcker T, Jung S, Montag C, Axmacher N. Genetic Alzheimer's Disease Risk Affects the Neural Mechanisms of Pattern Separation in Hippocampal Subfields. Curr Biol. 2020 Nov 2;30(21):4201-4212.e3. doi: 10.1016/j.cub.2020.08.042