Background and aims
Noradrenaline is a neurotransmitter. The brain synthesizes all of its noradrenaline in the locus coeruleus, a small nucleus in the brainstem. It is known that this nucleus is affected early on in the onset of Alzheimer's disease. Little is known, however, about how this relationship affects the symptoms and the course of the disease.
Findings obtained from study of this relationship could conceivably lead to treatment strategies that specifically target the noradrenaline system.
Study participants with mild Alzheimer's dementia, and patients with slight memory impairments, will be examined via magnetic resonance imaging (MRI), electroencephalography (EEG) and measurement of pupil width.
A full set of information about the study can be downloaded here (in German only): Flyer
Principle Investigator: PD Dr. Klaus Fließbach
Start of the study: 2013
Status: mono centric (DZNE Bonn), ongoing, recruiting active