Functional Neuroproteomics and Translational Biomarkers in Neurodegenerative Diseases
Priv.-Doz. Dr. Christian Johannes Gloeckner
Group Leader
Otfried-Müller-Str. 23
72076 Tübingen

johannes.gloeckner@dzne.de
 +49 7071 9254-400

Publications

The complete list of publications is found here.

Kishore A, Kumar Sreelatha AA, Sturm M, von-Zweydorf F, Pihlstrøm L, Raimondi F, Russell R, Lichtner P, Banerjee M, Krishnan S, Rajan R, Puthenveedu DK, Chung SJ, Bauer P, Riess O, Gloeckner CJ, Kruger R, Gasser T, Sharma M. Understanding the role of genetic variability in LRRK2 in Indian population. Movement Disorders. 2019 Apr 01; 34:496-505. doi: 10.1002/mds.27558
Weishäupl D, Schneider J, Peixoto Pinheiro B, Ruess C, Dold SM, von Zweydorf F, Gloeckner CJ, Schmidt J, Riess O, Schmidt T. Physiological and pathophysiological characteristics of ataxin-3 isoforms. J Biol Chem. 2019 Jan 11; 294:644-661. doi: 10.1074/jbc.RA118.005801
Hans F, Eckert M, von Zweydorf F, Gloeckner CJ, Kahle PJ. Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43. J Biol Chem. 2018 Oct 12; 293:16083-16099. doi: 10.1074/jbc.RA118.003440
Gilsbach BK, Eckert M, Gloeckner CJ. Regulation of LRRK2: Insights from structural and biochemical analysis. Biological Chemistry. 2018 Jun 27; 399:637-642. doi: 10.1515/hsz-2018-0132
Maria Dolores Perez Carrion, Silvia Marsicano, Federica Daniele, Antonella Marte, Francesca Pischedda, Eliana Di Cairano, Ester Piovesana, Felix Von Zweydorf, Elisabeth Kremmer, Christian Johannes Gloeckner, Franco Onofri, Carla Perego, Giovanni Piccoli. The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions. Scientific Reports. 2017 Nov 30; 7 doi: 10.1038/s41598-017-05760-9
Egon Deyaert, Lina Wauters, Giambattista Guaitoli, Albert Konijnenberg, Margaux Leemans, Susanne Terheyden, Arsen Petrovic, Rodrigo Gallardo, Laura M. Nederveen-Schippers, Panagiotis S. Athanasopoulos, Henderikus Pots, Peter J. M. Van Haastert, Frank Sobott, Christian Johannes Gloeckner, Rouslan Efremov, Arjan Kortholt, Wim Versées. A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover. Nature Communications. 2017 Nov 30; 8 doi: 10.1038/s41467-017-01103-4
Jonasz J. Weber, Matthias Golla, Giambattista Guaitoli, Pimthanya Wanichawan, Stefanie N. Hayer, Stefan Hauser, Ann-Christin Krahl, Maike Nagel, Sebastian Samer, Eleonora Aronica, Cathrine R. Carlson, Ludger Schöls, Olaf Riess, Christian J. Gloeckner, Huu P. Nguyen, Jeannette Hübener-Schmid. A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3. Brain. 2017 Apr 30; 140:1280-1299. doi: 10.1093/brain/awx039
Giambattista Guaitoli, Bernd K. Gilsbach, Francesco Raimondi, Christian Johannes Gloeckner. First model of dimeric LRRK2: The challenge of unrevealing the structure of a multidomain Parkinson's-associated protein. Biochemical Society Transactions. 2016 Dec 14; 44:1635-1641. doi: 10.1042/BST20160226
Porras P, Duesbury M, Fabregat A, Ueffing M, Orchard S, Gloeckner CJ, Hermjakob H. A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology. Proteomics. 2015 Jan 01; 15:1390-404. doi: 10.1002/pmic.201400390
Waschbusch D, Michels H, Strassheim S, Ossendorf E, Kessler D, Gloeckner CJ, Barnekow A. LRRK2 transport is regulated by its novel interacting partner Rab32. PloS one. 2014 Jan 01; 9:e111632. doi: 10.1371/journal.pone.0111632
Gillardon F, Kremmer E, Froehlich T, Ueffing M, Hengerer B, Gloeckner CJ. ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2? Journal of neuroscience methods. . 2013 Jan 01; 214:62-8. doi: 10.1016/j.jneumeth.2012.12.015
Meixner A, Boldt K, Van Troys M, Askenazi M, Gloeckner CJ, Bauer M, Marto JA, Ampe C, Kinkl N, Ueffing M. QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics. Molecular & cellular proteomics. 2001 Jan 01; 10:M110 001172. doi: 10.1074/mcp.M110.001172
Gloeckner CJ, Boldt K, Schumacher A, Roepman R, Ueffing M. A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. Proteomics. 2007 Jan 01; 7:4228-34. doi: 10.1002/pmic.200700038

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