Interventional Health Care Research (IHCR)
Priv.-Doz. Dr. Jochen René Thyrian, Dipl.-Psych.
Group Leader
Ellernholzstr. 1-2
17489 Greifswald
 +49 3834 86-7592

Areas of investigation/research focus

Health Care Research has been defined as “ the multidisciplinary field of scientific investigation that studies how social factors, financing systems, organizational structures and processes, health technologies and personal behaviors affect access to health care, the quality and cost of health care and ultimately our health and well-being. Its research domains are: individuals, families, organizations, institutions, communities and populations”. As such HCR is outcome-oriented (on the patient, health care provider, institutions and health system level), multidisciplinary and patient-oriented. HCR aims to describe, explain, design/ model, evaluate processes, evaluate efficacy/efficiency.  According to this research methods used in HCR are very diverse (assessment of qualitative and quantitative data, analyses of primary- and secondary data, systematic reviews, from experimental to descriptive study designs).

 more Infos

HCR research at DZNE aims to cover the whole spectrum of HCR and on the 26th of November 2012 the research group “interventional health care research (IHCR)” was established. Its research agenda is focused on the development and evaluation of interventions with population impact and their implementation into routine care. This was aimed at conducting as well as participating in intervention studies close to routine care, scientific analyses and monitoring of implementation processes.

With such a focus it is complimentary to already existing research groups at the DZNE site Rostock/ Greifswald (translational health care research, Prof. W. Hoffmann, clinical dementia research, Prof. S. Teipel) and at the DZNE site Witten (intervention strategies, Dr. M. Halek; intervention structures, Dr. B. Holle).  A close cooperation within these research groups is necessary and was established. Methods used in the research group are interventional studies, analyses and monitoring of implementation processes. IHCR has developed a distinct research agenda covering pressing issues in dementia care, which are:

  1. Timely diagnosis of dementia
  2. Optimizing treatment and care in primary care on the individual level
  3. Access, availability and quality of health care
  4. Caregiver burden and support

The four research lines focus on interventions tackling the most relevant targets in primary care. First of all procedures/ interventions need to be found to identify patients. Then there need to be effective interventions those patients can benefit from. Moreover, interventions are needed that target caregivers as well. Last not least, the health care system providing effective interventions needs to be developed and analyzed to be most effective. We have found effective interventions, but for translation into routine care adaptions and implementation studies are needed.

Key Publications

Jochen René Thyrian, Johannes Hertel, Diana Wucherer, Tilly Eichler, Bernhard Michalowsky, Adina Dreier-Wolfgramm, Ina Zwingmann, Ingo Kilimann, Stefan Teipel, Wolfgang Hoffmann. Effectiveness and safety of dementia care management in primary care: A randomized clinical trial. JAMA Psychiatry. 2017 Sep 30; 74:996-1004. doi: 10.1001/jamapsychiatry.2017.2124
Thyrian JR, Winter P, Eichler T, Reimann M, Wucherer D, Dreier A, et al. The burden of caring for people screened positive for dementia in primary care - results of the DelpHistudy. Zeitschrift für Gerontologie und Geriatrie. 2017 Jan 01; 50:4-13. doi: 10.1007/s00391-016- 1119-9
Jochen René Thyrian, Tilly Eichler, Bernhard Michalowsky, Diana Wucherer, Melanie Reimann, Johannes Hertel, Steffen Richter, Adina Dreier, Wolfgang Hoffmann. Community-Dwelling People Screened Positive for Dementia in Primary Care: A Comprehensive, Multivariate Descriptive Analysis Using Data from the DelpHi-Study. Journal of Alzheimer's Disease. 2016 May 09; 52:609-617. doi: 10.3233/JAD-151076
Thyrian JR, Fiß T, Dreier A, Böwing G, Angelow A, Lueke S, et al. Dementia: Life-and person-centered help in Mecklenburg-Western Pomerania, Germany (DelpHi)-study protocol for a randomised controlled trial. Trials. 2012 Jan 01; 13:56. doi: 0.1186/1745-6215- 13-56
Keller S, Maddock JE, Hannöver W, Thyrian JR, Basler HD. Multiple health risk behaviors in German first year university students. Prev Med. 2008 Mar 01; 46:189-95. doi: 10.1016/j.ypmed.2007.09.008


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