Prion Cell Biology
Prof. Dr. Ina Maja Vorberg
Group Leader
Venusberg-Campus 1/99
53127  Bonn
 +49 228 43302-560


The complete list of publications is found here.

Riemschoss K, Arndt V, Bolognesi B, von Eisenhart-Rothe P, Liu S, Buravlova O, Duernberger Y, Paulsen L, Hornberger A, Hossinger A, Lorenzo-Gotor N, Hogl S, Müller SA, Tartaglia G, Lichtenthaler SF, Vorberg IM. Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells. Life Sci Alliance. 2019 Jul 02; 2 doi: 10.26508/lsa.201800280
Chiesa R, Vorberg IM. Editorial overview: Prion disease: From drug discovery tools to clinical trials. Curr Opin Pharmacol. 2019 Feb 01; doi: 10.1016/j.coph.2019.05.002
Vorberg IM. All the Same? The Secret Life of Prion Strains within Their Target Cells. Viruses. 2019 Apr 09; 11:334. doi: 10.3390/v11040334
Vorberg I, Chiesa R. Experimental models to study prion disease pathogenesis and identify potential therapeutic compounds. Curr Opin Pharmacol. 2019 Feb 01; 44:28-39. doi: 10.1016/j.coph.2019.02.002
Schilling J, Broemer M, Atanassov I, Duernberger Y, Vorberg I, Dieterich C, Dagane A, Dittmar G, Wanker E, van Roon-Mom W, Winter J, Krauß S. Deregulated Splicing Is a Major Mechanism of RNA-Induced Toxicity in Huntington's Disease. J Mol Biol. 2019 Apr 19; 431:1869-1877. doi: 10.1016/j.jmb.2019.01.034
Duernberger Y, Liu S, Riemschoss K, Paulsen L, Bester R, Kuhn P-H, SchöllingM , Lichtenthaler S.F, Vorberg I. Prion Replication in the Mammalian Cytosol: Functional Regions within a Prion Domain Driving Induction, Propagation, and Inheritance. Mol Cell Biol. 2018 Jul 16; doi: 10.1128/MCB.00111-18
Rishibha Sachdev, Karin Kappes-Horn, Lydia Paulsen, Yvonne Duernberger, Catharina Pleschka, Philip Denner, Bishwajit Kundu, Jens Reimann, Ina Vorberg. Endoplasmic Reticulum Stress Induces Myostatin High Molecular Weight Aggregates and Impairs Mature Myostatin Secretion. Molecular Neurobiology. 2018 Oct 31; 55:8355-8373. doi: 10.1007/s12035-018-0997-9
Matthes F, Hettich MM, Schilling J, Flores-Dominguez D, Blank N, Wiglenda T, et al. Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis. Cell Death Discovery. ; in press
Chandramowlishwaran P, Sun M, Casey KL, Romanyuk AV, Grizel AV, Sopova JV, Rubel AA, Nussbaum-Krammer C, Vorberg I. Mammalian amyloidogenic proteins promote prion nucleation in yeast. jbc. 2018 Jan 12; doi: 10.1074/jbc.M117.809004
Franc Llorens, Katrin Thüne, Waqas Tahir, Eirini Kanata, Daniela Diaz-Lucena, Konstantinos Xanthopoulos, Eleni Kovatsi, Catharina Pleschka, Paula Garcia-Esparcia, Matthias Schmitz, Duru Ozbay, Susana Correia, Ângela Correia, Ira Milosevic, Olivier Andréoletti, Natalia Fernández-Borges, Ina M. Vorberg, Markus Glatzel, Theodoros Sklaviadis, Juan Maria Torres, Susanne Krasemann, Raquel Sánchez-Valle, Isidro Ferrer, Inga Zerr. YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias. Molecular Neurodegeneration. 2017 Nov 09; 12 doi: 10.1186/s13024-017-0226-4
Alana M Thackray, Alzbeta Cardova, Hanna Wolf, Lydia Pradl, Ina Vorberg, Walker S Jackson, Raymond Bujdoso. Genetic human prion disease modelled in PrP transgenic Drosophila. Biochemical Journal. 2017 Sep 30; 474:3253-3267. doi: 10.1042/BCJ20170462


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