Manuela Neumann
Molecular Neuropathology of Neurodegenerative Diseases
Prof. Dr. Manuela Neumann
Group Leader
Otfried-Müller-Str. 23
72072  Tübingen
 +49 7071 9254-100


The complete list of publications is found here.

Ian R. Mackenzie, Manuela Neumann. Reappraisal of TDP-43 pathology in FTLD-U subtypes. Acta Neuropathologica. 2017 Jun 30; 134:79-96.
Prudlo J, Konig J, Schuster C, Kasper E, Buttner A, Teipel S, Neumann M. TDP-43 pathology and cognition in ALS: A prospective clinicopathologic correlation study. Neurology. 2016 Sep 06; 87:1019-1023. doi: 10.1212/WNL.0000000000003062
Ian R. A. Mackenzie, Manuela Neumann. Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies. Journal of Neurochemistry. 2016 Jul 31; :54-70.
Marc Suárez-Calvet, Manuela Neumann, Thomas Arzberger, Claudia Abou-Ajram, Eva Funk, Hannelore Hartmann, Dieter Edbauer, Elisabeth Kremmer, Christoph Göbl, Moritz Resch, Benjamin Bourgeois, Tobias Madl, Stefan Reber, Daniel Jutzi, Marc-David Ruepp, Ian R. A. Mackenzie, Olaf Ansorge, Dorothee Dormann, Christian Haass. Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS. Acta Neuropathologica. 2016 Mar 31; 131:587-604. doi: 10.1007/s00401-016-1544-2
Ian R. A. Mackenzie, Petra Frick, Friedrich A. Grässer, Tania F. Gendron, Leonard Petrucelli, Neil R. Cashman, Dieter Edbauer, Elisabeth Kremmer, Johannes Prudlo, Dirk Troost, Manuela Neumann. Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers. Acta Neuropathologica. 2015 Nov 30; 130:845-861. doi: 10.1007/s00401-015-1476-2
Ian R. A. Mackenzie, Petra Frick, Manuela Neumann. The neuropathology associated with repeat expansions in the C9ORF72 gene. Acta Neuropathologica. 2014 Feb 28; 127:347-357.
Ian R. MacKenzie, Thomas Arzberger, Elisabeth Kremmer, Dirk Troost, Stefan Lorenzl, Kohji Mori, Shih-Ming Weng, Christian Haass, Hans A. Kretzschmar, Dieter Edbauer, Manuela Neumann. Dipeptide repeat protein pathology in C9ORF72 mutation cases: Clinico-pathological correlations. Acta Neuropathologica. 2013 Nov 30; 126:859-879. doi: 10.1007/s00401-013-1181-y
Dorothee Dormann, Tobias Madl, Chiara F. Valori, Eva Bentmann, Sabina Tahirovic, Claudia Abou-Ajram, Elisabeth Kremmer, Olaf Ansorge, Ian R.A. MacKenzie, Manuela Neumann, Christian Haass. Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS. EMBO Journal. 2012 Nov 13; 31:4258-4275. doi: 10.1038/emboj.2012.261
Rademakers R, Neumann M, Mackenzie IR. Advances in understanding the molecular basis of frontotemporal dementia. Nat Rev Neurol. 2012 Aug 01; 8:423-434. doi: 10.1038/nrneurol.2012.117
Manuela Neumann, Eva Bentmann, Dorothee Dormann, Ali Jawaid, Mariely Dejesus-Hernandez, Olaf Ansorge, Sigrun Roeber, Hans A. Kretzschmar, David G. Munoz, Hirofumi Kusaka, Osamu Yokota, Lee-Cyn Ang, Juan Bilbao, Rosa Rademakers, Christian Haass, Ian R. A. MacKenzie. FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain. 2010 Dec 31; 134:2595-2609. doi: 10.1093/brain/awr201
Mackenzie IR, Neumann M, Bigio EH, Cairns NJ, Alafuzoff I, Kril J, Kovacs GG, Ghetti B, Halliday G, Holm IE, Ince PG, Kamphorst W, Revesz T, Rozemuller AJ, Kumar-Singh S, Akiyama H, Baborie A, Spina S, Dickson DW, Trojanowski JQ, Mann DM. Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol. 2010 Jan 01; 119:1-4. doi: 10.1007/s00401-009-0612-2
Neumann M, Rademakers R, Roeber S, Baker M, Kretzschmar HA, Mackenzie IR. A new subtype of frontotemporal lobar degeneration with FUS pathology. Brain. 2009 Nov 01; 132:2922-2931. doi: 10.1093/brain/awp214
Neumann M, Kwong LK, Lee EB, Kremmer E, Flatley A, Xu Y, Forman MS, Troost D, Kretzschmar HA, Trojanowski JQ, Lee VM. Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathol. 2009 Feb 01; 117:137-149. doi: 10.1007/s00401-008-0477-9
Neumann M, Mackenzie IR, Cairns NJ, Boyer PJ, Markesbery WR, Smith CD, Taylor JP, Kretzschmar HA, Kimonis VE, Forman MS. TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol. 2007 Feb 01; 66:152-157. doi: 10.1097/nen.0b013e31803020b9
Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, Feiden W, Kretzschmar HA, Trojanowski JQ, Lee VM. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science. 2006 Oct 06; 314:130-133. doi: 10.1126/science.1134108


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