The focus of our research is on the cellular and molecular mechanisms of brain aging and age-related neurodegenerative diseases, with a special emphasis on the pathogenesis of Alzheimer´s disease and other cerebral amyloidoses.
We do primarily basic research with a focus on preclinical investigations of disease mechanisms. To foster the translation of our research to clinical applications, we coordinate the international Dominantly Inherited Alzheimer Network (DIAN) study in Germany, which aims to understand the rare genetic forms of Alzheimer's disease by longitudinal analysis of gene mutation carriers and non-mutation carrier siblings. Understanding this type of Alzheimer's disease is expected to provide important clues to the development of the more common sporadic form of Alzheimer´s disease.
Our department is part of the DZNE and the Hertie Institute of Clinical Brain Research at the University of Tübingen.