Mathias Jucker
Cell Biology of Neurological Diseases
Prof. Dr. Mathias Jucker
Group Leader
Otfried-Müller-Str. 27
72076  Tübingen
 +49 7071 29-86863

Areas of investigation/research focus

The focus of our research is on the cellular and molecular mechanisms of brain aging and age-related neurodegenerative diseases, with a special emphasis on the pathogenesis of Alzheimer´s disease and other cerebral amyloidoses. 

We do primarily basic research with a focus on preclinical investigations of disease mechanisms. To foster the translation of our research to clinical applications, we coordinate the international Dominantly Inherited Alzheimer Network (DIAN) study in Germany, which aims to understand the rare genetic forms of Alzheimer's disease by longitudinal analysis of gene mutation carriers and non-mutation carrier siblings. Understanding this type of Alzheimer's disease is expected to provide important clues to the development of the more common sporadic form of Alzheimer´s disease.

Our department is part of the DZNE and the Hertie Institute of Clinical Brain Research at the University of Tübingen.

Key Publications

Ruth E Uhlmann, Christine Rother, Jay Rasmussen, Juliane Schelle, Carina Bergmann, Emily M Ullrich Gavilanes, Sarah K Fritschi, Anika Buehler, Frank Baumann, Angelos Skodras, Rawaa Al-Shaana, Natalie Beschorner, Lan Ye, Stephan A Kaeser, Ulrike Obermüller, Søren Christensen, Fredrik Kartberg, Jeffrey B Stavenhagen, Jens-Ulrich Rahfeld, Holger Cynis, Fang Qian, Paul H Weinreb, Thierry Bussiere, Lary C Walker, Matthias Staufenbiel, Mathias Jucker. Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life. Nature Neuroscience. 2020 Dec 01; 23:1580-1588. doi: 10.1038/s41593-020-00737-w
Oliver Preische, Stephanie A. Schultz, Anja Apel, Jens Kuhle, Stephan A. Kaeser, Christian Barro, Susanne Gräber, Elke Kuder-Buletta, Christian LaFougere, Christoph Laske, Jonathan Vöglein, Johannes Levin, Colin L. Masters, Ralph Martins, Peter R. Schofield, Martin N. Rossor, Neill R. Graff-Radford, Stephen Salloway, Bernardino Ghetti, John M. Ringman, James M. Noble, Jasmeer Chhatwal, Alison M. Goate, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, Guoqiao Wang, Anne M. Fagan, Eric M. McDade, Brian A. Gordon, Mathias Jucker, et al. Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease. Nature Medicine. 2019 Jan 31; 25:277-283. doi: 10.1038/s41591-018-0304-3
Mathias Jucker, Lary C. Walker. Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases. Nature Neuroscience. 2018 Sep 30; 21:1341-1349. doi: 10.1038/s41593-018-0238-6
Lan Ye, Sarah K. Fritschi, Juliane Schelle, Ulrike Obermüller, Karoline Degenhardt, Stephan A. Kaeser, Yvonne S. Eisele, Lary C. Walker, Frank Baumann, Matthias Staufenbiel, Mathias Jucker. Persistence of Aβ seeds in APP null mouse brain. Nature Neuroscience. 2014 Dec 31; 18:1559-1561. doi: 10.1038/nn.4117
Yvonne S. Eisele, Ulrike Obermüller, Götz Heilbronner, Frank Baumann, Stephan A. Kaeser, Hartwig Wolburg, Lary C. Walker, Matthias Staufenbiel, Mathias Heikenwalder, Mathias Jucker. Peripherally applied Aβ-containing inoculates induce cerebral β-amyloidosis. Science. 2010 Nov 11; 330:980-982. doi: 10.1126/science.1194516


Thursdays 1:30-4:30 pm

Patients +49 800-7799001

(free of charge)

Professionals +49 180-779900

(9 Cent/Min. German landline, mobile and out of Germany possibly more expensive)

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