Cell Biology of Neurological Diseases
Prof. Dr. Mathias Jucker
Group Leader
Prof. Jucker is board director at the Hertie Institute for Clinical Brain Research
Otfried-Müller-Str. 27
72076 Tübingen

 +49 7071 29-86863

Areas of investigation/research focus

The focus of our research is on the cellular and molecular mechanisms of brain aging and age-related neurodegenerative diseases, with a special emphasis on the pathogenesis of Alzheimer´s disease and other cerebral amyloidoses. 

We do primarily basic research with a focus on preclinical investigations of disease mechanisms. To foster the translation of our research to clinical applications, we coordinate the international Dominantly Inherited Alzheimer Network (DIAN) study in Germany, which aims to understand the rare genetic forms of Alzheimer's disease by longitudinal analysis of gene mutation carriers and non-mutation carrier siblings. Understanding this type of Alzheimer's disease is expected to provide important clues to the development of the more common sporadic form of Alzheimer´s disease.

Our department is part of the DZNE and the Hertie Institute of Clinical Brain Research at the University of Tübingen.

Key Publications

Mehtap Bacioglu, Luis F. Maia, Oliver Preische, Juliane Schelle, Anja Apel, Stephan A. Kaeser, Manuel Schweighauser, Timo Eninger, Marius Lambert, Andrea Pilotto, Derya R. Shimshek, Ulf Neumann, Philipp J. Kahle, Matthias Staufenbiel, Manuela Neumann, Walter Maetzler, Jens Kuhle, Mathias Jucker. Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases. Neuron. 2016 Jul 05; 91:56-66. doi: 10.1016/j.neuron.2016.05.018
Lan Ye, Sarah K. Fritschi, Juliane Schelle, Ulrike Obermüller, Karoline Degenhardt, Stephan A. Kaeser, Yvonne S. Eisele, Lary C. Walker, Frank Baumann, Matthias Staufenbiel, Mathias Jucker. Persistence of Aβ seeds in APP null mouse brain. Nature Neuroscience. 2014 Dec 31; 18:1559-1561. doi: 10.1038/nn.4117
Yvonne S. Eisele, Ulrike Obermüller, Götz Heilbronner, Frank Baumann, Stephan A. Kaeser, Hartwig Wolburg, Lary C. Walker, Matthias Staufenbiel, Mathias Heikenwalder, Mathias Jucker. Peripherally applied Aβ-containing inoculates induce cerebral β-amyloidosis. Science. 2010 Nov 11; 330:980-982. doi: 10.1126/science.1194516
Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, ..., Jucker M. Exogenous induction of Aβ-amyloidogenesis is governed by intrinsic properties of agent and host. Science. 2006 Jan 01; 313:1781-4. doi: 10.1126/science.1131864
Mathias Jucker, Lary C. Walker. Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature. 2013 Sep 15; 501:45-51. doi: 10.1038/nature12481


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