Mathias Jucker
Cell Biology of Neurological Diseases
Prof. Dr. Mathias Jucker
Group Leader
Otfried-Müller-Str. 27
72076  Tübingen
 +49 7071 29-86863


The complete list of publications is found here.

Ruth E Uhlmann, Christine Rother, Jay Rasmussen, Juliane Schelle, Carina Bergmann, Emily M Ullrich Gavilanes, Sarah K Fritschi, Anika Buehler, Frank Baumann, Angelos Skodras, Rawaa Al-Shaana, Natalie Beschorner, Lan Ye, Stephan A Kaeser, Ulrike Obermüller, Søren Christensen, Fredrik Kartberg, Jeffrey B Stavenhagen, Jens-Ulrich Rahfeld, Holger Cynis, Fang Qian, Paul H Weinreb, Thierry Bussiere, Lary C Walker, Matthias Staufenbiel, Mathias Jucker. Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life. Nature Neuroscience. 2020 Dec 01; 23:1580-1588. doi: 10.1038/s41593-020-00737-w
Oliver Preische, Stephanie A. Schultz, Anja Apel, Jens Kuhle, Stephan A. Kaeser, Christian Barro, Susanne Gräber, Elke Kuder-Buletta, Christian LaFougere, Christoph Laske, Jonathan Vöglein, Johannes Levin, Colin L. Masters, Ralph Martins, Peter R. Schofield, Martin N. Rossor, Neill R. Graff-Radford, Stephen Salloway, Bernardino Ghetti, John M. Ringman, James M. Noble, Jasmeer Chhatwal, Alison M. Goate, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, Guoqiao Wang, Anne M. Fagan, Eric M. McDade, Brian A. Gordon, Mathias Jucker, et al. Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease. Nature Medicine. 2019 Jan 31; 25:277-283. doi: 10.1038/s41591-018-0304-3
Mathias Jucker, Lary C. Walker. Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases. Nature Neuroscience. 2018 Sep 30; 21:1341-1349. doi: 10.1038/s41593-018-0238-6
Rasmussen J, Mahler J, Beschorner N, Kaeser SA, Häsler LM, Baumann F, Nyström S, Portelius E, Blennow K, Lashley T, Fox NC, Sepulveda-Falla D, Glatzel M, Oblak AL, Ghetti B, Nilsson KPR, Hammarström P, Staufenbiel M, Walker LC, Jucker M. Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease. Proceedings of the National Acadamy of Sciences of the United States of America. 2017 Dec 05; 114:13018-13023. doi: 10.1073/pnas.1713215114
Petra Füger, Jasmin K. Hefendehl, Karthik Veeraraghavalu, Ann-Christin Wendeln, Christine Schlosser, Ulrike Obermüller, Bettina M. Wegenast-Braun, Jonas J. Neher, Peter Martus, Shinichi Kohsaka, Martin Thunemann, Robert Feil, Sangram S. Sisodia, Angelos Skodras, Mathias Jucker. Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging. Nature Neuroscience. 2017 Sep 30; 20:1371-1376. doi: 10.1038/nn.4631
Mehtap Bacioglu, Luis F. Maia, Oliver Preische, Juliane Schelle, Anja Apel, Stephan A. Kaeser, Manuel Schweighauser, Timo Eninger, Marius Lambert, Andrea Pilotto, Derya R. Shimshek, Ulf Neumann, Philipp J. Kahle, Matthias Staufenbiel, Manuela Neumann, Walter Maetzler, Jens Kuhle, Mathias Jucker. Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases. Neuron. 2016 Jul 05; 91:56-66. doi: 10.1016/j.neuron.2016.05.018
Lan Ye, Sarah K. Fritschi, Juliane Schelle, Ulrike Obermüller, Karoline Degenhardt, Stephan A. Kaeser, Yvonne S. Eisele, Lary C. Walker, Frank Baumann, Matthias Staufenbiel, Mathias Jucker. Persistence of Aβ seeds in APP null mouse brain. Nature Neuroscience. 2014 Dec 31; 18:1559-1561. doi: 10.1038/nn.4117
Manuel Schweighauser, Mehtap Bacioglu, Sarah K. Fritschi, Derya R. Shimshek, Philipp J. Kahle, Yvonne S. Eisele, Mathias Jucker. Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts. Acta Neuropathologica. 2014 Dec 31; 129:157-159. doi: 10.1007/s00401-014-1360-5
Luis F. Maia, Stephan A. Kaeser, Julia Reichwald, Marius Lambert, Ulrike Obermüller, Juliane Schelle, Jörg Odenthal, Peter Martus, Matthias Staufenbiel, Mathias Jucker. Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models. EMBO Molecular Medicine. 2014 Dec 31; 7:895-903. doi: 10.15252/emmm.201505026
Mathias Jucker, Lary C. Walker. Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature. 2013 Sep 15; 501:45-51. doi: 10.1038/nature12481
Luis F. Maia, Stephan A. Kaeser, Julia Reichwald, Michael Hruscha, Peter Martus, Matthias Staufenbiel, Mathias Jucker. Changes in amyloid-β and tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein. Science Translational Medicine. 2013 Jul 09; 5 doi: 10.1126/scitranslmed.3006446
Nicholas H. Varvel, Stefan A. Grathwohl, Frank Baumann, Christian Liebig, Andrea Bosch, Bianca Brawek, Dietmar R. Thal, Israel F. Charo, Frank L. Heppner, Adriano Aguzzi, Olga Garaschuk, Richard M. Ransohoff, Mathias Jucker. Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells. Proceedings of the National Academy of Sciences of the United States of America. 2012 Oct 29; 109:18150-18155. doi: 10.1073/pnas.1210150109
Eisenberg D, Jucker M. The amyloid state of proteins in human diseases. Cell. 2012 Mar 16; 148:1188-203. doi: 10.1016/j.cell.2012.02.022
Yvonne S. Eisele, Ulrike Obermüller, Götz Heilbronner, Frank Baumann, Stephan A. Kaeser, Hartwig Wolburg, Lary C. Walker, Matthias Staufenbiel, Mathias Heikenwalder, Mathias Jucker. Peripherally applied Aβ-containing inoculates induce cerebral β-amyloidosis. Science. 2010 Nov 11; 330:980-982. doi: 10.1126/science.1194516


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