Biomarker-assisted early detection of dementias
Prof. Dr. Oliver Peters
Clinical Study Team
Hindenburgdamm 30
12203 Berlin

oliver.peters@dzne.de
 +49 30 450517-628

Areas of investigation/research focus

Our group puts its focus on biomarker-assisted, in particular Alzheimer’s disease (AD). We are especially interested in cerebrospinal fluid biomarkers. We have gained expertise in analyzing cerebrospinal fluid for established biomarkers as Tau and Abeta. Furthermore we aim to establish new biomarkers for a more specific diagnosis of neurodegenerative diseases. We also have a focus on discriminating AD from mood disorders like depression.

We are specialized in conducting interventional clinical trials in cooperation with the pharmaceutical industry as well as observational clinical trials like DELCODE and DESCRIBE-FTD.

Among others, we are associated with the Berlin Institute of Health (BIH), the Max-Delbrück-Centre (MDC) and the European Alzheimer’s Disease Consortium (EADC).

Beside this, our research group is also involved in the development of health care research. Therefore, we are participating in several gerontological research projects with the focus on dementia.

In our health care research unit it is our aim to improve and stabilize the situation for people with dementia and their caregivers in home dementia care for as long as possible. We focus on the potential of assistive technologies. Our previous user studies dealing in various stages of development with the acceptance, usability and feasibility of technical devices in everyday life. The aim is to develop and evaluate new assistive technologies that can provide relief for people with dementia and their caregivers.

Key Publications

Carola G. Schipke, Ann De Vos, Manuel Fuentes, Dirk Jacobs, Eugeen Vanmechelen, Oliver Petersc. Neurogranin and BACE1 in CSF as Potential Biomarkers Differentiating Depression with Cognitive Deficits from Early Alzheimer’s Disease: A Pilot Study. Dementia and Geriatric Cognitive Disorders. Dement Geriatr Cogn Dis Extra. 2018 Aug 06; 8:277-89. doi: 10.1159/000489847
Jessen F, Spottke A, Boecker H, Brosseron F, Buerger K, Catak C, Fliessbach K, Franke C, Fuentes M, Heneka MT, Janowitz D, Kilimann I, Laske C, Menne F, Nestor P, Peters O, Priller J, Pross V, Ramirez A, Schneider A, Speck O, Spruth EJ, Teipel S, Vukovich R, Westerteicher C, Wiltfang J, Wolfsgruber S, Wagner M, Düzel E. Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE). Alzheimers Res Ther. 2018 Feb 07; 10:15. doi: 10.1186/s13195-017-0314-2
Willemijn J. Jansen, Rik Ossenkoppele, Betty M. Tijms, Anne M. Fagan, Oskar Hansson, William E. Klunk, Wiesje M. Van Der Flier, Victor L. Villemagne, Giovanni B. Frisoni, Adam S. Fleisher, Alberto Lleó, Mark A. Mintun, Anders Wallin, Sebastiaan Engelborghs, Duk L. Na, Gäel Chételat, José Luis Molinuevo, Susan M. Landau, Niklas Mattsson, Johannes Kornhuber, Osama Sabri, Christopher C. Rowe, Lucilla Parnetti, Julius Popp, Tormod Fladby, William J. Jagust, Pauline Aalten, Dong Young Lee, Rik Vandenberghe, Catarina Resende De Oliveira, Elisabeth Kapaki, Lutz Froelich, Adrian Ivanoiu, Tomasz Gabryelewicz, Marcel M. Verbeek, Páscual Sanchez-Juan, Helmut Hildebrandt, Vincent Camus, Marzena Zboch, David J. Brooks, Alexander Drzezga, Juha O. Rinne, Andrew Newberg, Alexandre De Mendonça, Marie Sarazin, Gil D. Rabinovici, Karine Madsen, Milica G. Kramberger, Agneta Nordberg, Vincent Mok, Barbara Mroczko, David A. Wolk, Philipp T. Meyer, Magda Tsolaki, Philip Scheltens, Frans R.J. Verhey, Pieter Jelle Visser, Dag Aarsland, Daniel Alcolea, Myriam Alexander, Ina S. Almdahl, Steven E. Arnold, Inês Baldeiras, Henryk Barthel, Bart N.M. Van Berckel, Kaj Blennow, Mark A. Van Buchem, Enrica Cavedo, Kewei Chen, Elena Chipi, Ann D. Cohen, Stefan Förster, Juan Fortea, Kristian S. Frederiksen, Yvonne Freund-Levi, Olymbia Gkatzima, Mark Forrest Gordon, Timo Grimmer, Harald Hampel, Lucrezia Hausner, Sabine Hellwig, Sanna-Kaisa Herukka, Peter Johannsen, Aleksandra Klimkowicz-Mrowiec, Sebastian Köhler, Norman Koglin, Koen Van Laere, Mony De Leon, Viviana Lisetti, Wolfgang Maier, Jan Marcusson, Olga Meulenbroek, Hanne M. Møllergård, John C. Morris, Arto Nordlund, Gerald P. Novak, George P. Paraskevas, Gayan Perera, Oliver Peters, Inez H.G.B. Ramakers, Lorena Rami, Eloy Rodríguez-Rodríguez, Catherine M. Roe, Uros Rot, Eckart Rüther, Isabel Santana, Johannes Schröder, Sang W. Seo, Hilkka Sorininen, Luiza Spiru, Erik Stomrud, Hanne Struyfs, Charlotte E. Teunissen, Stephanie J.B. Vos, Linda J.C. Van Waalwijk Van Doorn, Gunhild Waldemar, Åsa K. Wallin, Jens Wiltfang, Henrik Zetterberg. Association of cerebral amyloid-β Aggregation with cognitive functioning in persons without dementia. JAMA Psychiatry. 2017 Dec 31; 75:84-95. doi: 10.1001/jamapsychiatry.2017.3391
Herlind Megges, Silka Dawn Freieslebena, Christina Röscha, Nina Knolld, Lauri Wessele, Oliver Peters. User experience and clinical effectiveness with two wearable global positioning system devices in home dementia care. Alzheimer's & Dementia: Translational Research & Clinical Interventions.. Alzheimer's & Dementia: Translational Research & Clinical Interventions. ; 4:636-644. doi: 10.1016/j.trci.2018.10.002
Lutz Frölich, Oliver Peters, Piotr Lewczuk, Oliver Gruber, Stefan J. Teipel, Hermann J. Gertz, Holger Jahn, Frank Jessen, Alexander Kurz, Christian Luckhaus, Michael Hüll, Johannes Pantel, Friedel M. Reischies, Johannes Schröder, Michael Wagner, Otto Rienhoff, Stefanie Wolf, Chris Bauer, Johannes Schuchhardt, Isabella Heuser, Eckart Rüther, Fritz Henn, Wolfgang Maier, Jens Wiltfang, Johannes Kornhuber. Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer's dementia. Alzheimer's Research and Therapy. 2017 Oct 09; 9 doi: 10.1186/s13195-017-0301-7

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