Hans Jörgen Grabe
Biomarkers of dementia in the general population
Prof. Dr. Hans Jörgen Grabe
Group Leader
Ellernholzstr. 1-2
17489 Greifswald

hans.grabe@dzne.de
 +49 3834 86-6915

Areas of investigation/research focus

1.Genetic factors in Dementia

At the University Medicine of Greifswald we have extensive clinical phenotype data and whole body MRI-images from the population-based cohorts SHIP and TREND (SHIP/TREND, n> 8000) and inpatients cohorts (GANI_MED, n>4500). Additionally, we use MRI data from the UKBiobank and other cohorts as well.

We coordinate the German activities in the JPND project “Brain Imaging, cognition, Dementia and next generation GEnomics: a Transdisciplinary approach to search for risk and protective factors of neurodegenerative disease” (BRIDGET). Together with international partners, we search for common and rare genetic variants of AD and will establish new brain imaging markers for early risk assessment of dementia. Additionally, we perform genome-wide sequencing for the determination of the degree of methylation (Methyl-C sequencing).

Along with the molecular parameters clinical and brain imaging phenotypes will be analyzed. My group is responsible for new structural MRI markers (see 2.)

 more Infos

2. Novel MRI markers of ageing

Based on previous neuroimaging studies we apply a high-dimensional pattern classification algorithm to MRI-based FreeSurfer data to generate the FS-BA score for brain aging in SHIP subjects and the FS-AD score for the identification of Alzheimer´s like brain atrophy pattern.  These scores are now used in biomarker research for early AD.

3. Urine Metabolomics in Dementia

Based on NMR-measured urine metabolites we have established a metabolic age score indicating biological ageing as departure from chronological age. As part of this research we have identified metabolites that are associated with ageing and gray matter loss in the brain. These metabolites will be tested in special ageing cohorts (e.g. DELCODE) for their association to Alzheimer´s disease.

Schlüsselpublikationen

Johannes Hertel, Nele Friedrich, Katharina Wittfeld, Maik Pietzner, Kathrin Budde, Sandra Van Der Auwera, Tobias Lohmann, Alexander Teumer, Henry Völzke, Matthias Nauck, Hans Jörgen Grabe. Measuring Biological Age via Metabonomics: The Metabolic Age Score. Journal of Proteome Research. 2016 Feb 04; 15:400-410. doi: 10.1021/acs.jproteome.5b00561
Mohamad Habes, Guray Erus, Jon B. Toledo, Tianhao Zhang, Nick Bryan, Lenore J. Launer, Yves Rosseel, Deborah Janowitz, Jimit Doshi, Sandra Van Der Auwera, Bettina Von Sarnowski, Katrin Hegenscheid, Norbert Hosten, Georg Homuth, Henry Völzke, Ulf Schminke, Wolfgang Hoffmann, Hans J. Grabe, Christos Davatzikos. White matter hyperintensities and imaging patterns of brain ageing in the general population. Brain. 2016 Mar 31; 139:1164-1179. doi: 10.1093/brain/aww008
Deborah Janowitz, Katharina Wittfeld, Jan Terock, Harald Jürgen Freyberger, Katrin Hegenscheid, Henry Völzke, Mohamad Habes, Norbert Hosten, Nele Friedrich, Matthias Nauck, Grazyna Domanska, Hans Jörgen Grabe. Association between waist circumference and gray matter volume in 2344 individuals from two adult community-based samples. NeuroImage. 2015 Nov 04; 122:149-157. doi: 10.1016/j.neuroimage.2015.07.086

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